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Term:R-loop disassembly
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Accession:GO:0062176 term browser browse the term
Definition:A DNA metabolic process that results in the disassembly of R-loops. R-loops are three-stranded nucleic acid structures consisitng of an RNA:DNA heteroduplex and a looped-out non-template strand. Aberrant formation and persistence of R-loops block transcription elongation and cause DNA damage. Mechanisms that resolve R-loops are essential for genome stability.

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R-loop disassembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ddx21 DExD-box helicase 21 JBrowse link 20 32,213,147 32,232,632 RGD:1624291
G Ddx23 DEAD-box helicase 23 JBrowse link 7 140,325,453 140,342,730 RGD:1624291
G Primpol primase and DNA directed polymerase JBrowse link 16 48,863,385 48,900,409 RGD:1624291
G Sirt7 sirtuin 7 JBrowse link 10 109,796,046 109,802,821 RGD:1624291
G Srpk2 SRSF protein kinase 2 JBrowse link 4 7,994,025 8,187,455 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    metabolic process 12097
      cellular metabolic process 10918
        cellular macromolecule metabolic process 8393
          DNA metabolic process 911
            R-loop disassembly 5
Path 2
Term Annotations click to browse term
  biological_process 19858
    metabolic process 12097
      organic substance metabolic process 11495
        organic substance biosynthetic process 6000
          macromolecule biosynthetic process 5060
            cellular macromolecule biosynthetic process 4951
              DNA replication 251
                DNA-dependent DNA replication 148
                  R-loop disassembly 5
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.