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ONTOLOGY REPORT - ANNOTATIONS


Term:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
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Accession:GO:0070059 term browser browse the term
Definition:A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
Synonyms:exact_synonym: ER stress-induced apoptosis;   apoptosis in response to ER stress;   apoptosis triggered by ER stress;   endoplasmic reticulum stress-induced apoptosis;   intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress
 broad_synonym: apoptosis in response to endoplasmic reticulum stress


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intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 ISO
ISS
(MGI:MGI:3774040|PMID:18056262)
GO_REF:0000024
RGD
UniProt
PMID:18056262 GO_REF:0000024, MGI:MGI:3774040 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 ISO (MGI:MGI:5621265|PMID:16407291) RGD PMID:16407291 MGI:MGI:5621265 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G Atf4 activating transcription factor 4 ISS
ISO
GO_REF:0000024
(MGI:MGI:4879048|PMID:21159964), (MGI:MGI:5496937|PMID:23624402)
UniProt
RGD
PMID:21159964, PMID:23624402 GO_REF:0000024, MGI:MGI:4879048, MGI:MGI:5496937 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 ISO (PMID:19061639) RGD PMID:19061639 NCBI chr 1:197,855,912...197,875,038 JBrowse link
G Atp2a3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 ISO
IEA
(PMID:16725111)
GO_REF:0000107
RGD
Ensembl
PMID:16725111 GO_REF:0000107 NCBI chr10:59,528,849...59,560,440
Ensembl chr10:59,529,785...59,560,433
JBrowse link
G Bag6 BAG cochaperone 6 ISO
ISS
(MGI:MGI:3774040|PMID:18056262)
GO_REF:0000024
RGD
UniProt
PMID:18056262 GO_REF:0000024, MGI:MGI:3774040 NCBI chr20:5,124,512...5,138,084
Ensembl chr20:5,125,349...5,138,084
JBrowse link
G Bak1 BCL2-antagonist/killer 1 ISO MGI:MGI:99702|UniProtKB:P10415 (MGI:MGI:2667259|PMID:12847083), (MGI:MGI:3575207|PMID:15776018) RGD PMID:12847083, PMID:15776018 MGI:MGI:2667259, MGI:MGI:3575207 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator IEA
ISO
ISS
GO_REF:0000107
MGI:MGI:1097161|UniProtKB:P10415 (MGI:MGI:2667259|PMID:12847083), (MGI:MGI:3575207|PMID:15776018)
GO_REF:0000024
(PMID:16645094)
Ensembl
RGD
UniProt
PMID:12847083, PMID:15776018, PMID:16645094 GO_REF:0000024, GO_REF:0000107, MGI:MGI:2667259, MGI:MGI:3575207 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bbc3 Bcl-2 binding component 3 ISO
IBA
ISS
(PMID:16407291)
PMID:21873635
(MGI:MGI:4879048|PMID:21159964), (MGI:MGI:5448480|PMID:22761832), (MGI:MGI:5621265|PMID:16407291)
GO_REF:0000024
RGD
UniProt
PMID:16407291, PMID:21159964, PMID:22761832, PMID:21873635 GO_REF:0000024, MGI:MGI:4879048, MGI:MGI:5448480, MGI:MGI:5621265, RGD:13792537 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcl2 BCL2, apoptosis regulator ISO
IEA
(PMID:15776018)
GO_REF:0000107
RGD
Ensembl
PMID:15776018 GO_REF:0000107 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Brsk2 BR serine/threonine kinase 2 ISO
IEA
(PMID:22713462)
GO_REF:0000107
RGD
Ensembl
PMID:22713462 GO_REF:0000107 NCBI chr 1:214,918,757...214,940,883
Ensembl chr 1:214,927,172...214,947,624
JBrowse link
G Casp12 caspase 12 NAS
IEA
ISO
PMID:10638761
GO_REF:0000107
MGI:MGI:1097161|MGI:MGI:99702 (MGI:MGI:1351404|PMID:10638761), (MGI:MGI:2667259|PMID:12847083), (MGI:MGI:5634893|PMID:12097332)
Ensembl
RGD
PMID:10638761, PMID:12097332, PMID:12847083, PMID:10638761 GO_REF:0000107, MGI:MGI:1351404, MGI:MGI:2667259, MGI:MGI:5634893, RGD:10047306 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
JBrowse link
G Casp4 caspase 4 ISO (PMID:15123740) RGD PMID:15123740 NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta ISO (MGI:MGI:1335331|PMID:9531536) RGD PMID:9531536 MGI:MGI:1335331 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Chac1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 ISO (PMID:19109178) RGD PMID:19109178 NCBI chr 3:111,160,205...111,163,425
Ensembl chr 3:111,160,205...111,163,425
JBrowse link
G Dab2ip DAB2 interacting protein ISO
IEA
(MGI:MGI:3796479|PMID:18281285)
GO_REF:0000107
RGD
Ensembl
PMID:18281285 GO_REF:0000107, MGI:MGI:3796479 NCBI chr 3:14,889,263...15,060,286
Ensembl chr 3:14,889,510...15,060,286
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 IEA
ISO
IBA
ISS
GO_REF:0000107
MGI:MGI:2179046 (MGI:MGI:1335331|PMID:9531536), (MGI:MGI:2158984|PMID:11854325), (MGI:MGI:4879048|PMID:21159964), (MGI:MGI:5496937|PMID:23624402)
PMID:21873635
(PMID:15322075), (PMID:18940792), (PMID:20829347)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:9531536, PMID:11854325, PMID:15322075, PMID:18940792, PMID:20829347, PMID:21159964, PMID:23624402, PMID:21873635 GO_REF:0000024, GO_REF:0000107, MGI:MGI:1335331, MGI:MGI:2158984, MGI:MGI:4879048, MGI:MGI:5496937, RGD:13792537 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dnajc10 DnaJ heat shock protein family (Hsp40) member C10 ISO (PMID:19122239) RGD PMID:19122239 NCBI chr 3:67,538,289...67,578,308
Ensembl chr 3:67,538,289...67,578,306
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 ISO MGI:MGI:2177666 (MGI:MGI:2136067|PMID:11430819) RGD PMID:11430819 MGI:MGI:2136067 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 ISO
IBA
(MGI:MGI:1929557|PMID:11146108), (MGI:MGI:3840374|PMID:19328063)
PMID:21873635
RGD PMID:11146108, PMID:19328063, PMID:21873635 MGI:MGI:1929557, MGI:MGI:3840374, RGD:13792537 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Ern2 endoplasmic reticulum to nucleus signaling 2 ISO
IBA
(MGI:MGI:1346198|PMID:9755171)
PMID:21873635
RGD PMID:9755171, PMID:21873635 MGI:MGI:1346198, RGD:13792537 NCBI chr 1:192,126,023...192,142,865
Ensembl chr 1:192,126,023...192,142,854
JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha ISO
ISS
(MGI:MGI:4366390|PMID:19752026)
GO_REF:0000024
RGD
UniProt
PMID:19752026 GO_REF:0000024, MGI:MGI:4366390 NCBI chr15:19,619,947...19,655,381
Ensembl chr15:19,619,973...19,655,381
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta ISO (MGI:MGI:5619738|PMID:23028846) RGD PMID:23028846 MGI:MGI:5619738 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Ins2 insulin 2 ISO MGI:MGI:1857572 (MGI:MGI:2158984|PMID:11854325) RGD PMID:11854325 MGI:MGI:2158984 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:4366390|PMID:19752026)
Ensembl
UniProt
RGD
PMID:19752026 GO_REF:0000024, GO_REF:0000107, MGI:MGI:4366390 NCBI chr 4:140,247,297...140,580,749
Ensembl chr 4:140,247,313...140,580,748
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 ISO (MGI:MGI:5616327|PMID:12050113) RGD PMID:12050113 MGI:MGI:5616327 NCBI chr 1:15,412,603...15,613,752
Ensembl chr 1:15,412,603...15,613,746
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 ISO (MGI:MGI:5621265|PMID:16407291) RGD PMID:16407291 MGI:MGI:5621265 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
JBrowse link
G Pml PML nuclear body scaffold ISO (MGI:MGI:4849347|PMID:21030605) RGD PMID:21030605 MGI:MGI:4849347 NCBI chr 8:63,002,515...63,034,310
Ensembl chr 8:63,004,870...63,034,226
JBrowse link
G Rnf186 ring finger protein 186 ISO
IBA
(PMID:23896122)
PMID:21873635
RGD PMID:23896122, PMID:21873635 RGD:13792537 NCBI chr 5:157,416,897...157,418,121
Ensembl chr 5:157,416,897...157,418,121
JBrowse link
G Selenok selenoprotein K IEA
ISO
GO_REF:0000107
(PMID:20692228)
Ensembl
RGD
PMID:20692228 GO_REF:0000107 NCBI chr16:6,035,926...6,044,240
Ensembl chr16:6,035,926...6,044,239
JBrowse link
G Tmbim6 transmembrane BAX inhibitor motif containing 6 ISO MGI:MGI:3052422 (MGI:MGI:3050914|PMID:15304216) RGD PMID:15304216 MGI:MGI:3050914 NCBI chr 7:141,039,433...141,070,269
Ensembl chr 7:141,034,982...141,069,989
JBrowse link
G Tmem117 transmembrane protein 117 ISO
IBA
(PMID:28285135)
PMID:21873635
RGD PMID:28285135, PMID:21873635 RGD:13792537 NCBI chr 7:135,880,294...136,403,012
Ensembl chr 7:136,182,224...136,403,012
JBrowse link
G Tp53 tumor protein p53 ISO (MGI:MGI:5621265|PMID:16407291) RGD PMID:16407291 MGI:MGI:5621265 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trib3 tribbles pseudokinase 3 ISO
ISS
(PMID:15775988)
GO_REF:0000024
RGD
UniProt
PMID:15775988 GO_REF:0000024 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571
JBrowse link
G Ube2k ubiquitin-conjugating enzyme E2K IMP PMID:18710920 MGI PMID:18710920 RGD:8554156 NCBI chr14:44,289,247...44,348,691
Ensembl chr14:44,289,247...44,348,691
JBrowse link
G Xbp1 X-box binding protein 1 ISO (MGI:MGI:3840374|PMID:19328063) RGD PMID:19328063 MGI:MGI:3840374 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l1 Bcl2-like 1 ISS
ISO
GO_REF:0000024
(PMID:29507230)
UniProt
RGD
PMID:29507230 GO_REF:0000024 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Creb3 cAMP responsive element binding protein 3 ISO (PMID:16940180) RGD PMID:16940180 NCBI chr 5:59,063,532...59,068,196
Ensembl chr 5:59,063,531...59,068,188
JBrowse link
G Creb3l1 cAMP responsive element binding protein 3-like 1 IMP
ISO
PMID:15665855
(MGI:MGI:5616321|PMID:15665855)
RGD PMID:15665855, PMID:15665855 MGI:MGI:5616321, RGD:1558627 NCBI chr 3:80,892,433...80,933,283
Ensembl chr 3:80,892,435...80,933,283
JBrowse link
G Grina glutamate ionotropic receptor NMDA type subunit associated protein 1 ISO MGI:MGI:1341830|MGI:MGI:99682 (MGI:MGI:5525071|PMID:22240901) RGD PMID:22240901 MGI:MGI:5525071 NCBI chr 7:117,304,742...117,307,916
Ensembl chr 7:117,304,742...117,307,916
JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 IMP
IBA
ISO
PMID:15102845
PMID:21873635
(PMID:15102845)
RGD PMID:15102845, PMID:15102845, PMID:21873635 RGD:1304324, RGD:13792537 NCBI chr19:11,046,905...11,057,440
Ensembl chr19:11,046,909...11,057,254
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A ISO (PMID:12150907), (PMID:20625543) RGD PMID:12150907, PMID:20625543 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B ISO (PMID:12150907), (PMID:20625543) RGD PMID:12150907, PMID:20625543 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma ISO (MGI:MGI:5495588|PMID:23453807) RGD PMID:23453807 MGI:MGI:5495588 NCBI chr  X:156,254,187...156,280,046
Ensembl chr  X:156,257,173...156,270,748
JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 ISO (PMID:21857923) RGD PMID:21857923 NCBI chr 7:132,857,311...133,018,549
Ensembl chr 7:132,857,628...133,018,584
JBrowse link
G Ngf nerve growth factor NAS PMID:21266243 ParkinsonsUK-UCL PMID:21266243 RGD:10047230 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase ISO
ISS
UniProtKB:P58281 (PMID:23453807)
GO_REF:0000024
(MGI:MGI:5495588|PMID:23453807)
RGD
ParkinsonsUK-UCL
PMID:23453807 GO_REF:0000024, MGI:MGI:5495588 NCBI chr11:74,717,600...74,793,902
Ensembl chr11:74,720,254...74,793,803
JBrowse link
G Park7 Parkinsonism associated deglycase ISO
IEA
UniProtKB:Q99LX0 (PMID:14652021)
GO_REF:0000107
(MGI:MGI:5613479|PMID:14652021)
RGD
Ensembl
PMID:14652021 GO_REF:0000107, MGI:MGI:5613479 NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724
JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 ISO MGI:MGI:2181360 (MGI:MGI:4836774|PMID:20811152) RGD PMID:20811152 MGI:MGI:4836774 NCBI chr12:9,496,044...9,501,211
Ensembl chr12:9,496,044...9,501,213
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISO
ISS
(MGI:MGI:5433837|PMID:21113145)
(PMID:10973942), (PMID:11439185), (PMID:12150907), (PMID:21113145), (PMID:23453807)
GO_REF:0000024
RGD
ParkinsonsUK-UCL
PMID:10973942, PMID:11439185, PMID:12150907, PMID:21113145, PMID:23453807 GO_REF:0000024, MGI:MGI:5433837 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 ISO (MGI:MGI:5619464|PMID:21216966) RGD PMID:21216966 MGI:MGI:5619464 NCBI chr 3:164,665,462...164,711,936
Ensembl chr 3:164,665,532...164,711,848
JBrowse link
G Selenos selenoprotein S ISO
IEA
(PMID:17210132)
GO_REF:0000107
RGD
Ensembl
PMID:17210132 GO_REF:0000107 NCBI chr 1:126,979,579...126,989,344
Ensembl chr 1:126,979,575...126,989,344
JBrowse link
G Syvn1 synoviolin 1 ISO MGI:MGI:2679656 (MGI:MGI:3575050|PMID:15611074)
(PMID:12459480), (PMID:17059562)
RGD PMID:12459480, PMID:15611074, PMID:17059562 MGI:MGI:3575050 NCBI chr 1:221,409,281...221,416,229
Ensembl chr 1:221,409,271...221,417,886
JBrowse link
G Tmbim6 transmembrane BAX inhibitor motif containing 6 ISO
IEA
MGI:MGI:1913418 (MGI:MGI:5525071|PMID:22240901)
GO_REF:0000107
(PMID:21075086)
RGD
Ensembl
PMID:21075086, PMID:22240901 GO_REF:0000107, MGI:MGI:5525071 NCBI chr 7:141,039,433...141,070,269
Ensembl chr 7:141,034,982...141,069,989
JBrowse link
G Txndc12 thioredoxin domain containing 12 ISO (PMID:18628206) RGD PMID:18628206 NCBI chr 5:128,450,830...128,475,858
Ensembl chr 5:128,450,680...128,475,864
JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein ISO (MGI:MGI:3629256|PMID:16571599) RGD PMID:16571599 MGI:MGI:3629256 NCBI chr14:78,640,707...78,665,224
Ensembl chr14:78,640,620...78,665,966
JBrowse link
G Xbp1 X-box binding protein 1 ISO
IMP
(PMID:19135031)
PMID:20625543
RGD PMID:19135031, PMID:20625543 RGD:10047191 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hyou1 hypoxia up-regulated 1 ISO
IEA
(MGI:MGI:3697528|PMID:17116640)
GO_REF:0000107
RGD
Ensembl
PMID:17116640 GO_REF:0000107, MGI:MGI:3697528 NCBI chr 8:48,699,796...48,711,912
Ensembl chr 8:48,699,769...48,711,910
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISO UniProtKB:O15354 (MGI:MGI:3697528|PMID:17116640), (MGI:MGI:5495588|PMID:23453807) RGD PMID:17116640, PMID:23453807 MGI:MGI:3697528, MGI:MGI:5495588 NCBI chr 1:48,880,015...50,069,998 JBrowse link
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bok BCL2 family apoptosis regulator BOK ISS
ISO
GO_REF:0000024
(MGI:MGI:5648772|PMID:26015568), (MGI:MGI:5796067|PMID:26949185)
UniProt
RGD
PMID:26015568, PMID:26949185 GO_REF:0000024, MGI:MGI:5648772, MGI:MGI:5796067 NCBI chr 9:100,829,593...100,840,498
Ensembl chr 9:100,829,552...100,840,504
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 ISO MGI:MGI:1913418 (MGI:MGI:5525071|PMID:22240901) RGD PMID:22240901 MGI:MGI:5525071 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Nck1 NCK adaptor protein 1 ISO (PMID:14676213)
UniProtKB:O55033 (MGI:MGI:5613475|PMID:16835242)
RGD PMID:14676213, PMID:16835242 MGI:MGI:5613475 NCBI chr 8:108,787,797...108,847,779
Ensembl chr 8:108,787,798...108,847,779
JBrowse link
G Nck2 NCK adaptor protein 2 ISO UniProtKB:Q99M51 (MGI:MGI:5613475|PMID:16835242) RGD PMID:16835242 MGI:MGI:5613475 NCBI chr 9:50,246,767...50,373,307
Ensembl chr 9:50,247,692...50,373,284
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 ISO (MGI:MGI:5619464|PMID:21216966) RGD PMID:21216966 MGI:MGI:5619464 NCBI chr18:63,415,298...63,489,240
Ensembl chr18:63,415,306...63,488,027
JBrowse link
G Rnf183 ring finger protein 183 ISO (PMID:29507230) RGD PMID:29507230 NCBI chr 5:78,283,722...78,292,729
Ensembl chr 5:78,284,879...78,285,451
JBrowse link
G Serinc3 serine incorporator 3 ISO (MGI:MGI:2671011|PMID:12486168) RGD PMID:12486168 MGI:MGI:2671011 NCBI chr 3:160,018,643...160,038,078
Ensembl chr 3:160,018,646...160,038,078
JBrowse link
G Sirt1 sirtuin 1 ISO (MGI:MGI:5607229|PMID:20955178) RGD PMID:20955178 MGI:MGI:5607229 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Spop speckle type BTB/POZ protein ISO MGI:MGI:102851 (MGI:MGI:4836774|PMID:20811152) RGD PMID:20811152 MGI:MGI:4836774 NCBI chr10:83,231,187...83,311,987
Ensembl chr10:83,231,238...83,311,592
JBrowse link
regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 ISO (PMID:23000344) RGD PMID:23000344 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Erp29 endoplasmic reticulum protein 29 ISO (MGI:MGI:5613446|PMID:24370996) RGD PMID:24370996 MGI:MGI:5613446 NCBI chr12:40,619,377...40,625,884
Ensembl chr12:40,619,377...40,625,883
JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 ISO (MGI:MGI:5613477|PMID:15147274) RGD PMID:15147274 MGI:MGI:5613477 NCBI chr19:11,046,905...11,057,440
Ensembl chr19:11,046,909...11,057,254
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    signaling 7583
      signal transduction 7011
        intracellular signal transduction 2594
          intrinsic apoptotic signaling pathway 304
            intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 65
              negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway + 22
              neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress + 2
              positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 9
              regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway + 32
Path 2
Term Annotations click to browse term
  biological_process 20027
    biological regulation 13773
      regulation of biological process 13075
        regulation of cellular process 12561
          signal transduction 7011
            apoptotic signaling pathway 630
              intrinsic apoptotic signaling pathway 304
                intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 65
                  negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway + 22
                  neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress + 2
                  positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 9
                  regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway + 32
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.