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ONTOLOGY REPORT - ANNOTATIONS


Term:interleukin-6-mediated signaling pathway
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Accession:GO:0070102 term browser browse the term
Definition:A series of molecular signals initiated by the binding of interleukin-6 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: interleukin-6-mediated signalling pathway
 related_synonym: IL-6-mediated signaling pathway


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interleukin-6-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cebpa CCAAT/enhancer binding protein alpha IEA
ISO
GO_REF:0000107
(PMID:24429361)
Ensembl
RGD
PMID:24429361 GO_REF:0000107 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Ctr9 CTR9 homolog, Paf1/RNA polymerase II complex component ISO (MGI:MGI:5319608|PMID:17911113) RGD PMID:17911113 MGI:MGI:5319608 NCBI chr 1:175,839,140...175,869,167
Ensembl chr 1:175,839,108...175,869,165
JBrowse link
G Fer FER tyrosine kinase IEA
ISO
GO_REF:0000107
(PMID:19147545)
Ensembl
RGD
PMID:19147545 GO_REF:0000107 NCBI chr 9:111,557,804...111,868,583
Ensembl chr 9:111,597,037...111,862,670
JBrowse link
G Gab1 GRB2-associated binding protein 1 ISO MGI:MGI:1926435 (MGI:MGI:1355592|PMID:10779359) RGD PMID:10779359 MGI:MGI:1355592 NCBI chr19:30,794,290...30,903,819
Ensembl chr19:30,794,571...30,902,008
JBrowse link
G Il6 interleukin 6 ISO
ISS
(PMID:12552091), (PMID:16946298), (PMID:30670152)
(MGI:MGI:3769957|PMID:16330325), (MGI:MGI:50330|PMID:1312474), (MGI:MGI:6142555|PMID:27893700), (MGI:MGI:84432|PMID:8910279)
GO_REF:0000024
RGD
UniProt
PMID:1312474, PMID:8910279, PMID:12552091, PMID:16330325, PMID:16946298, PMID:27893700, PMID:30670152 GO_REF:0000024, MGI:MGI:3769957, MGI:MGI:50330, MGI:MGI:6142555, MGI:MGI:84432 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Il6r interleukin 6 receptor ISO
ISS
IBA
IEA
(PMID:12643274)
(MGI:MGI:50330|PMID:1312474), (MGI:MGI:6142555|PMID:27893700)
GO_REF:0000024
PMID:21873635
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:1312474, PMID:12643274, PMID:27893700, PMID:21873635 GO_REF:0000024, GO_REF:0000107, MGI:MGI:50330, MGI:MGI:6142555, RGD:13792537 NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628
JBrowse link
G Il6st interleukin 6 signal transducer IMP
IEA
ISO
GO_REF:0000107
(MGI:MGI:5629863|PMID:25731159)
(PMID:12643274), (PMID:2261637), (PMID:25731159)
Ensembl
RGD
PMID:2261637, PMID:12643274, PMID:25731159, PMID:18280048 GO_REF:0000107, MGI:MGI:5629863, RGD:5686900 NCBI chr 2:44,279,199...44,319,427
Ensembl chr 2:44,289,393...44,314,944
JBrowse link
G Smad4 SMAD family member 4 ISO
IEA
(MGI:MGI:3769957|PMID:16330325)
GO_REF:0000107
RGD
Ensembl
PMID:16330325 GO_REF:0000107, MGI:MGI:3769957 NCBI chr18:69,626,682...69,657,373
Ensembl chr18:69,627,757...69,671,199
JBrowse link
G Spi1 Spi-1 proto-oncogene ISO (PMID:24429361) RGD PMID:24429361 NCBI chr 3:79,918,127...79,937,708
Ensembl chr 3:79,918,969...79,938,301
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO (PMID:25731159)
(MGI:MGI:5629863|PMID:25731159)
RGD PMID:25731159 MGI:MGI:5629863 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G St18 ST18 C2H2C-type zinc finger transcription factor IEA
ISO
GO_REF:0000107
(PMID:18676404)
Ensembl
RGD
PMID:18676404 GO_REF:0000107 NCBI chr 5:12,437,617...12,787,223
Ensembl chr 5:12,437,525...12,563,429
JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISS
ISO
GO_REF:0000024
(PMID:12359225), (PMID:12552091), (PMID:16835372), (PMID:16946298), (PMID:17324931), (PMID:24429361)
UniProt
RGD
PMID:12359225, PMID:12552091, PMID:16835372, PMID:16946298, PMID:17324931, PMID:24429361 GO_REF:0000024 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tut4 terminal uridylyl transferase 4 ISO (MGI:MGI:4365679|PMID:19701194) RGD PMID:19701194 MGI:MGI:4365679 NCBI chr 5:128,063,880...128,168,726
Ensembl chr 5:128,083,118...128,168,207
JBrowse link
G Yap1 Yes1 associated transcriptional regulator ISO (PMID:25731159)
(MGI:MGI:5629863|PMID:25731159)
RGD PMID:25731159 MGI:MGI:5629863 NCBI chr 8:6,133,014...6,204,240
Ensembl chr 8:6,135,493...6,203,579
JBrowse link
negative regulation of interleukin-6-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il6st interleukin 6 signal transducer ISO (PMID:8353278) RGD PMID:8353278 NCBI chr 2:44,279,199...44,319,427
Ensembl chr 2:44,289,393...44,314,944
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 ISO
ISS
(PMID:12359225)
GO_REF:0000024
(MGI:MGI:4941441|PMID:20484139)
RGD
UniProt
PMID:12359225, PMID:20484139 GO_REF:0000024, MGI:MGI:4941441 NCBI chr18:63,415,298...63,489,240
Ensembl chr18:63,415,306...63,488,027
JBrowse link
positive regulation of interleukin-6-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1qtnf4 C1q and TNF related 4 ISO (PMID:21658842) RGD PMID:21658842 NCBI chr 3:79,713,580...79,718,018
Ensembl chr 3:79,713,567...79,718,025
JBrowse link
G Gfi1 growth factor independent 1 transcriptional repressor ISO (PMID:11060035) RGD PMID:11060035 NCBI chr14:3,058,035...3,073,332
Ensembl chr14:3,058,993...3,068,371
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 ISO (PMID:31827280)
(MGI:MGI:6401044|PMID:31827281)
RGD PMID:31827280, PMID:31827281 MGI:MGI:6401044 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    signaling 7583
      signal transduction 7011
        cell surface receptor signaling pathway 2761
          cytokine-mediated signaling pathway 406
            interleukin-6-mediated signaling pathway 18
              negative regulation of interleukin-6-mediated signaling pathway 2
              positive regulation of interleukin-6-mediated signaling pathway 3
              regulation of interleukin-6-mediated signaling pathway + 5
Path 2
Term Annotations click to browse term
  biological_process 20027
    response to stimulus 10583
      response to chemical 6343
        response to organic substance 3865
          cellular response to organic substance 2845
            cellular response to cytokine stimulus 998
              cytokine-mediated signaling pathway 406
                interleukin-6-mediated signaling pathway 18
                  negative regulation of interleukin-6-mediated signaling pathway 2
                  positive regulation of interleukin-6-mediated signaling pathway 3
                  regulation of interleukin-6-mediated signaling pathway + 5
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.