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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of interleukin-6-mediated signaling pathway
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Accession:GO:0070103 term browser browse the term
Definition:Any process that modulates the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-6-mediated binding to a cell surface receptor.
Synonyms:exact_synonym: regulation of IL-6-mediated signaling pathway;   regulation of interleukin-6-mediated signalling pathway


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negative regulation of interleukin-6-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il6st interleukin 6 signal transducer ISO (PMID:8353278) RGD PMID:8353278 NCBI chr 2:44,279,199...44,319,427
Ensembl chr 2:44,289,393...44,314,944
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 ISO
ISS
(PMID:12359225)
GO_REF:0000024
(MGI:MGI:4941441|PMID:20484139)
RGD
UniProt
PMID:12359225, PMID:20484139 GO_REF:0000024, MGI:MGI:4941441 NCBI chr18:63,415,298...63,489,240
Ensembl chr18:63,415,306...63,488,027
JBrowse link
positive regulation of interleukin-6-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1qtnf4 C1q and TNF related 4 ISO (PMID:21658842) RGD PMID:21658842 NCBI chr 3:79,713,580...79,718,018
Ensembl chr 3:79,713,567...79,718,025
JBrowse link
G Gfi1 growth factor independent 1 transcriptional repressor ISO (PMID:11060035) RGD PMID:11060035 NCBI chr14:3,058,035...3,073,332
Ensembl chr14:3,058,993...3,068,371
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 ISO (PMID:31827280)
(MGI:MGI:6401044|PMID:31827281)
RGD PMID:31827280, PMID:31827281 MGI:MGI:6401044 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    regulation of biological process 13075
      regulation of response to stimulus 3981
        regulation of signal transduction 2934
          regulation of cytokine-mediated signaling pathway 113
            regulation of interleukin-6-mediated signaling pathway 5
              negative regulation of interleukin-6-mediated signaling pathway 2
              positive regulation of interleukin-6-mediated signaling pathway 3
Path 2
Term Annotations click to browse term
  biological_process 20028
    response to stimulus 10583
      response to chemical 6342
        response to organic substance 3865
          response to cytokine 1132
            cellular response to cytokine stimulus 998
              cytokine-mediated signaling pathway 406
                regulation of cytokine-mediated signaling pathway 113
                  regulation of interleukin-6-mediated signaling pathway 5
                    negative regulation of interleukin-6-mediated signaling pathway 2
                    positive regulation of interleukin-6-mediated signaling pathway 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.