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ONTOLOGY REPORT - ANNOTATIONS


Term:actin-mediated cell contraction
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Accession:GO:0070252 term browser browse the term
Definition:The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body.


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actin-mediated cell contraction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ACTC1 actin alpha cardiac muscle 1 JBrowse link 30 2,514,825 2,519,398 RGD:9068941
G EMP2 epithelial membrane protein 2 JBrowse link 6 32,026,908 32,060,447 RGD:13508589
G MYH2 myosin heavy chain 2 JBrowse link 5 34,810,791 34,838,177 RGD:13508589
G PARVA parvin alpha JBrowse link 21 35,382,447 35,536,791 RGD:13508589
G PDPN podoplanin JBrowse link 2 83,552,735 83,581,375 RGD:13508589
actin-myosin filament sliding term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ACTC1 actin alpha cardiac muscle 1 JBrowse link 30 2,514,825 2,519,398 RGD:13508589
apical constriction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CCDC88C coiled-coil domain containing 88C JBrowse link 8 62,123,934 62,245,485 RGD:9068941
G EPB41L5 erythrocyte membrane protein band 4.1 like 5 JBrowse link 19 29,916,994 30,063,243 RGD:9068941
G FRMD6 FERM domain containing 6 JBrowse link 8 27,757,320 27,989,319 RGD:13508589
G PARD3 par-3 family cell polarity regulator JBrowse link 2 2,252,262 2,791,459 RGD:9068941
G ROCK1 Rho associated coiled-coil containing protein kinase 1 JBrowse link 7 66,862,614 67,001,538 RGD:9068941
atrial cardiac muscle cell action potential term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ANK2 ankyrin 2 JBrowse link 32 32,484,196 33,143,295 RGD:13508589
G KCNA5 potassium voltage-gated channel subfamily A member 5 JBrowse link 27 39,808,987 39,810,789 RGD:9068941
G KCNE5 potassium voltage-gated channel subfamily E regulatory subunit 5 JBrowse link X 82,844,188 82,845,641 RGD:13508589
G KCNQ1 potassium voltage-gated channel subfamily Q member 1 JBrowse link 18 46,554,390 46,830,533 RGD:13508589
G NUP155 nucleoporin 155 JBrowse link 4 71,340,109 71,409,286 RGD:13508589
G SCN3B sodium voltage-gated channel beta subunit 3 JBrowse link 5 10,783,235 10,808,342 RGD:13508589
G SCN5A sodium voltage-gated channel alpha subunit 5 JBrowse link 23 8,278,844 8,374,614 RGD:9068941
cardiac muscle cell action potential involved in contraction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CACNA1C calcium voltage-gated channel subunit alpha1 C JBrowse link 27 44,007,363 44,748,251 RGD:9068941
G CACNA1D calcium voltage-gated channel subunit alpha1 D JBrowse link 20 36,189,986 36,488,460 RGD:13508589
G CACNA1G calcium voltage-gated channel subunit alpha1 G JBrowse link 9 26,481,148 26,544,511 RGD:13508589
G CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 JBrowse link 18 21,561,091 21,949,970 RGD:13508589
G KCNE1 potassium voltage-gated channel subfamily E regulatory subunit 1 JBrowse link 31 29,858,428 29,868,315 RGD:9068941
G KCNE2 potassium voltage-gated channel subfamily E regulatory subunit 2 JBrowse link 31 29,777,154 29,777,839 RGD:9068941
G KCNJ2 potassium inwardly rectifying channel subfamily J member 2 JBrowse link 9 16,468,938 16,475,722 RGD:13508589
G PKP2 plakophilin 2 JBrowse link 27 16,023,186 16,109,978 RGD:9068941
G SCN1A sodium voltage-gated channel alpha subunit 1 JBrowse link 36 11,105,936 11,245,978 RGD:13508589
G SCN1B sodium voltage-gated channel beta subunit 1 JBrowse link 1 117,504,428 117,510,666 RGD:13508589
G SCN2B sodium voltage-gated channel beta subunit 2 JBrowse link 5 15,514,760 15,534,179 RGD:13508589
G SCN3B sodium voltage-gated channel beta subunit 3 JBrowse link 5 10,783,235 10,808,342 RGD:13508589
G SCN4B sodium voltage-gated channel beta subunit 4 JBrowse link 5 15,552,347 15,564,085 RGD:9068941
G SCN5A sodium voltage-gated channel alpha subunit 5 JBrowse link 23 8,278,844 8,374,614 RGD:9068941
cardiac muscle cell contraction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CAMK2D calcium/calmodulin dependent protein kinase II delta JBrowse link 32 33,223,093 33,525,783 RGD:9068941
G SGCD sarcoglycan delta JBrowse link 4 53,259,332 54,178,228 RGD:9068941
G SLC9A1 solute carrier family 9 member A1 JBrowse link 2 73,054,742 73,103,364 RGD:9068941
cytoplasmic actin-based contraction involved in cell motility term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G LIMCH1 LIM and calponin homology domains 1 JBrowse link 13 38,518,653 38,816,804 RGD:9068941
G SHTN1 shootin 1 JBrowse link 28 27,422,086 27,517,190 RGD:9068941
G VIL1 villin 1 JBrowse link 37 25,065,887 25,090,238 RGD:13508589
membrane depolarization during atrial cardiac muscle cell action potential term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CACNA1C calcium voltage-gated channel subunit alpha1 C JBrowse link 27 44,007,363 44,748,251 RGD:13508589
G CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 JBrowse link 2 18,537,100 18,787,728 RGD:9068941
G SCN5A sodium voltage-gated channel alpha subunit 5 JBrowse link 23 8,278,844 8,374,614 RGD:13508589
membrane repolarization during atrial cardiac muscle cell action potential term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G KCNA5 potassium voltage-gated channel subfamily A member 5 JBrowse link 27 39,808,987 39,810,789 RGD:9068941
G KCNJ5 potassium inwardly rectifying channel subfamily J member 5 JBrowse link 5 5,736,544 5,760,705 RGD:13508589
G KCNN2 potassium calcium-activated channel subfamily N member 2 JBrowse link 11 4,279,362 4,423,080 RGD:9068941
G KCNQ1 potassium voltage-gated channel subfamily Q member 1 JBrowse link 18 46,554,390 46,830,533 RGD:9068941
membrane repolarization during ventricular cardiac muscle cell action potential term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G KCNE1 potassium voltage-gated channel subfamily E regulatory subunit 1 JBrowse link 31 29,858,428 29,868,315 RGD:13508589
G KCNE2 potassium voltage-gated channel subfamily E regulatory subunit 2 JBrowse link 31 29,777,154 29,777,839 RGD:13508589
G KCNE3 potassium voltage-gated channel subfamily E regulatory subunit 3 JBrowse link 21 23,860,727 23,872,194 RGD:13508589
G KCNE4 potassium voltage-gated channel subfamily E regulatory subunit 4 JBrowse link 37 28,994,797 28,998,596 RGD:13508589
G KCNE5 potassium voltage-gated channel subfamily E regulatory subunit 5 JBrowse link X 82,844,188 82,845,641 RGD:13508589
G KCNH2 potassium voltage-gated channel subfamily H member 2 JBrowse link 16 15,009,031 15,041,786 RGD:13508589
G KCNJ8 potassium inwardly rectifying channel subfamily J member 8 JBrowse link 27 25,368,565 25,375,754 RGD:9068941
G KCNQ1 potassium voltage-gated channel subfamily Q member 1 JBrowse link 18 46,554,390 46,830,533 RGD:13508589
muscle filament sliding term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G MYH6 myosin heavy chain 6 JBrowse link 8 3,629,459 3,655,946 RGD:9068941
G MYH7 myosin heavy chain 7 JBrowse link 8 3,660,155 3,677,650 RGD:13508589
G MYH8 myosin heavy chain 8 JBrowse link 5 34,696,377 34,725,515 RGD:13508589
G TNNT2 troponin T2, cardiac type JBrowse link 7 1,598,306 1,620,531 RGD:9068941
G TPM1 tropomyosin 1 JBrowse link 30 27,636,407 27,664,907 RGD:9068941
negative regulation of hepatic stellate cell contraction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G NOS1 nitric oxide synthase 1 JBrowse link 26 13,787,341 13,895,176 RGD:9068941
negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G KCNE3 potassium voltage-gated channel subfamily E regulatory subunit 3 JBrowse link 21 23,860,727 23,872,194 RGD:13508589
negative regulation of muscle filament sliding term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G DBN1 drebrin 1 JBrowse link 4 35,899,969 35,913,015 RGD:9068941
negative regulation of ventricular cardiac muscle cell action potential term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BIN1 bridging integrator 1 JBrowse link 19 23,503,934 23,534,407 RGD:9068941
positive regulation of atrial cardiac muscle cell action potential term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G TRPM4 transient receptor potential cation channel subfamily M member 4 JBrowse link 1 107,261,760 107,304,157 RGD:9068941
positive regulation of cardiac muscle cell contraction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CACNA1H calcium voltage-gated channel subunit alpha1 H JBrowse link 6 39,510,129 39,533,129 RGD:9068941
G LOC100684154 sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF-like JBrowse link 23 49,131,218 49,134,728 RGD:9068941
positive regulation of hepatic stellate cell contraction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ACTA2 actin alpha 2, smooth muscle JBrowse link 26 38,700,434 38,714,915 RGD:9068941
positive regulation of myofibroblast contraction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G PTGER3 prostaglandin E receptor 3 JBrowse link 6 74,932,789 74,986,573 RGD:9068941
positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G RNF207 ring finger protein 207 JBrowse link 5 60,105,200 60,119,902 RGD:13508589
regulation of atrial cardiac muscle cell action potential term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ANK2 ankyrin 2 JBrowse link 32 32,484,196 33,143,295 RGD:13508589
G GJA5 gap junction protein alpha 5 JBrowse link 17 58,289,327 58,305,315 RGD:13508589
G RYR2 ryanodine receptor 2 JBrowse link 4 2,371,868 2,908,132 RGD:13508589
regulation of cardiac muscle cell action potential involved in regulation of contraction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AKAP9 A-kinase anchoring protein 9 JBrowse link 14 17,590,256 17,743,646 RGD:9068941
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 JBrowse link 26 8,148,181 8,209,392 RGD:9068941
G CAV3 caveolin 3 JBrowse link 20 9,384,901 9,398,055 RGD:13508589
G FGF13 fibroblast growth factor 13 JBrowse link X 108,658,113 109,156,096 RGD:9068941
G HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 JBrowse link 30 36,637,492 36,656,194 RGD:9068941
G RANGRF RAN guanine nucleotide release factor JBrowse link 5 33,084,355 33,085,810 RGD:13508589
regulation of cardiac muscle cell contraction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ADORA1 adenosine A1 receptor JBrowse link 7 44,819 74,217 RGD:9068941
G ADRB1 adrenoceptor beta 1 JBrowse link 28 24,908,224 24,909,684 RGD:9068941
G AKAP6 A-kinase anchoring protein 6 JBrowse link 8 11,403,655 11,882,684 RGD:9068941
G ANK2 ankyrin 2 JBrowse link 32 32,484,196 33,143,295 RGD:9068941
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 JBrowse link 17 53,828,482 53,847,043 RGD:9068941
G CASQ2 calsequestrin 2 JBrowse link 17 53,233,966 53,299,093 RGD:9068941
G FXYD1 FXYD domain containing ion transport regulator 1 JBrowse link 1 117,436,239 117,440,619 RGD:9068941
G GATA4 GATA binding protein 4 JBrowse link 25 26,126,172 26,211,474 RGD:9068941
G KCNJ2 potassium inwardly rectifying channel subfamily J member 2 JBrowse link 9 16,468,938 16,475,722 RGD:9068941
G PDE4B phosphodiesterase 4B JBrowse link 5 44,063,145 44,606,070 RGD:9068941
G PDE4D phosphodiesterase 4D JBrowse link 2 45,843,767 47,245,263 RGD:13508589
G PLN phospholamban JBrowse link 1 58,579,095 58,590,541 RGD:13508589
G SCN5A sodium voltage-gated channel alpha subunit 5 JBrowse link 23 8,278,844 8,374,614 RGD:13508589
G SRI sorcin JBrowse link 14 14,257,375 14,274,816 RGD:9068941
G STC1 stanniocalcin 1 JBrowse link 25 33,615,436 33,628,138 RGD:13508589
G SUMO1 small ubiquitin like modifier 1 JBrowse link 37 11,199,937 11,229,743 RGD:13508589
regulation of muscle filament sliding term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G MYLK2 myosin light chain kinase 2 JBrowse link 24 21,284,309 21,297,889 RGD:13508589
regulation of muscle filament sliding speed term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G TNNC1 troponin C1, slow skeletal and cardiac type JBrowse link 20 37,313,983 37,317,288 RGD:13508589
G TNNT2 troponin T2, cardiac type JBrowse link 7 1,598,306 1,620,531 RGD:9068941
regulation of myofibroblast contraction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G PDPN podoplanin JBrowse link 2 83,552,735 83,581,375 RGD:13508589
regulation of ventricular cardiac muscle cell action potential term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CACNA1C calcium voltage-gated channel subunit alpha1 C JBrowse link 27 44,007,363 44,748,251 RGD:13508589
G CAV1 caveolin 1 JBrowse link 14 55,458,934 55,494,563 RGD:13508589
G CTNNA3 catenin alpha 3 JBrowse link 4 17,364,121 19,035,836 RGD:13508589
G DLG1 discs large MAGUK scaffold protein 1 JBrowse link 33 30,016,323 30,253,180 RGD:9068941
G DSC2 desmocollin 2 JBrowse link 7 58,369,316 58,402,028 RGD:13508589
G DSG2 desmoglein 2 JBrowse link 7 57,981,918 58,030,197 RGD:9068941
G DSP desmoplakin JBrowse link 35 7,479,628 7,524,732 RGD:13508589
G JUP junction plakoglobin JBrowse link 9 21,028,773 21,053,071 RGD:13508589
G PKP2 plakophilin 2 JBrowse link 27 16,023,186 16,109,978 RGD:9068941
G RYR2 ryanodine receptor 2 JBrowse link 4 2,371,868 2,908,132 RGD:13508589
G TRPM4 transient receptor potential cation channel subfamily M member 4 JBrowse link 1 107,261,760 107,304,157 RGD:13508589
regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G DLG1 discs large MAGUK scaffold protein 1 JBrowse link 33 30,016,323 30,253,180 RGD:9068941
ventricular cardiac muscle cell action potential term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ANK2 ankyrin 2 JBrowse link 32 32,484,196 33,143,295 RGD:13508589
G CAV3 caveolin 3 JBrowse link 20 9,384,901 9,398,055 RGD:9068941
G GJA5 gap junction protein alpha 5 JBrowse link 17 58,289,327 58,305,315 RGD:13508589
G GPD1L glycerol-3-phosphate dehydrogenase 1 like JBrowse link 23 12,568,914 12,631,903 RGD:9068941
G KCNE1 potassium voltage-gated channel subfamily E regulatory subunit 1 JBrowse link 31 29,858,428 29,868,315 RGD:13508589
G KCNE2 potassium voltage-gated channel subfamily E regulatory subunit 2 JBrowse link 31 29,777,154 29,777,839 RGD:13508589
G KCNE3 potassium voltage-gated channel subfamily E regulatory subunit 3 JBrowse link 21 23,860,727 23,872,194 RGD:13508589
G KCNE4 potassium voltage-gated channel subfamily E regulatory subunit 4 JBrowse link 37 28,994,797 28,998,596 RGD:13508589
G KCNE5 potassium voltage-gated channel subfamily E regulatory subunit 5 JBrowse link X 82,844,188 82,845,641 RGD:13508589
G KCNH2 potassium voltage-gated channel subfamily H member 2 JBrowse link 16 15,009,031 15,041,786 RGD:9068941
G KCNQ1 potassium voltage-gated channel subfamily Q member 1 JBrowse link 18 46,554,390 46,830,533 RGD:9068941
G NEDD4L NEDD4 like E3 ubiquitin protein ligase JBrowse link 1 17,629,163 17,858,471 RGD:9068941
G PKP2 plakophilin 2 JBrowse link 27 16,023,186 16,109,978 RGD:9068941
G RYR2 ryanodine receptor 2 JBrowse link 4 2,371,868 2,908,132 RGD:13508589
G SCN3B sodium voltage-gated channel beta subunit 3 JBrowse link 5 10,783,235 10,808,342 RGD:13508589
G SCN5A sodium voltage-gated channel alpha subunit 5 JBrowse link 23 8,278,844 8,374,614 RGD:13508589
G SNTA1 syntrophin alpha 1 JBrowse link 24 22,636,716 22,665,828 RGD:13508589

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16041
    cellular process 15295
      actin filament-based process 784
        actin filament-based movement 118
          actin-mediated cell contraction 89
            actin-myosin filament sliding + 9
            apical constriction + 5
            cardiac muscle cell contraction + 65
            cytoplasmic actin-based contraction involved in cell motility + 3
            hepatic stellate cell contraction + 2
            myofibroblast contraction + 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.