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ONTOLOGY REPORT - ANNOTATIONS


Term:tyrosyl-DNA phosphodiesterase activity
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Accession:GO:0070259 term browser browse the term
Definition:Catalysis of the hydrolysis of phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between a DNA topoisomerase and DNA.
Comment:See also the molecular function term 'DNA topoisomerase type I activity ; GO:0003917'.


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3'-tyrosyl-DNA phosphodiesterase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tdp1 tyrosyl-DNA phosphodiesterase 1 IEA
IBA
ISO
ISS
GO_REF:0000107
PMID:21873635
(PMID:17118488), (PMID:17576665), (PMID:17948061), (PMID:22822062)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:17118488, PMID:17576665, PMID:17948061, PMID:22822062, PMID:21873635 GO_REF:0000024, GO_REF:0000107, RGD:13792537 NCBI chr 6:123,895,860...123,963,688
Ensembl chr 6:123,897,956...123,963,675
JBrowse link
5'-tyrosyl-DNA phosphodiesterase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tdp2 tyrosyl-DNA phosphodiesterase 2 IEA
ISS
ISO
IBA
GO_REF:0000107
GO_REF:0000024
(PMID:19794497), (PMID:21030584), (PMID:22405347), (PMID:22822062)
PMID:21873635
Ensembl
UniProt
RGD
PMID:19794497, PMID:21030584, PMID:22405347, PMID:22822062, PMID:21873635 GO_REF:0000024, GO_REF:0000107, RGD:13792537 NCBI chr17:42,229,667...42,241,025
Ensembl chr17:42,229,642...42,241,066
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20457
    catalytic activity 6065
      catalytic activity, acting on DNA 213
        tyrosyl-DNA phosphodiesterase activity 2
          3'-tyrosyl-DNA phosphodiesterase activity 1
          5'-tyrosyl-DNA phosphodiesterase activity 1
Path 2
Term Annotations click to browse term
  molecular_function 20457
    catalytic activity 6065
      hydrolase activity 2637
        hydrolase activity, acting on ester bonds 804
          phosphoric ester hydrolase activity 377
            phosphoric diester hydrolase activity 90
              tyrosyl-DNA phosphodiesterase activity 2
                3'-tyrosyl-DNA phosphodiesterase activity 1
                5'-tyrosyl-DNA phosphodiesterase activity 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.