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ONTOLOGY REPORT - ANNOTATIONS


Term:cornification
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Accession:GO:0070268 term browser browse the term
Definition:A type of programmed cell death that occurs in the epidermis, morphologically and biochemically distinct from apoptosis. It leads to the formation of corneocytes, i.e. dead keratinocytes containing an amalgam of specific proteins (e.g., keratin, loricrin, SPR and involucrin) and lipids (e.g., fatty acids and ceramides), which are necessary for the function of the cornified skin layer (mechanical resistance, elasticity, water repellence and structural stability).


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cornification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp14 caspase 14 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 7:13,938,376...13,944,286
Ensembl chr 7:13,938,302...13,945,130
JBrowse link
G Cers3 ceramide synthase 3 ISO (MGI:MGI:5303015|PMID:22038835) RGD PMID:22038835 MGI:MGI:5303015 NCBI chr 1:127,706,618...127,781,041
Ensembl chr 1:127,648,234...127,781,017
JBrowse link
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 ISO MGI:MGI:3039046 (MGI:MGI:5466369|PMID:22366455) RGD PMID:22366455 MGI:MGI:5466369 NCBI chr 4:116,261,796...116,278,615
Ensembl chr 4:116,261,796...116,278,615
JBrowse link
G Tmem79 transmembrane protein 79 ISO MGI:MGI:1856947 (MGI:MGI:5519142|PMID:24084074) RGD PMID:24084074 MGI:MGI:5519142 NCBI chr 2:187,701,522...187,706,452
Ensembl chr 2:187,697,509...187,706,321
JBrowse link
negative regulation of cornification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdsn corneodesmosin ISO (PMID:26014679) RGD PMID:26014679 NCBI chr20:3,704,626...3,707,266 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    multicellular organismal process 9055
      keratinization 39
        cornification 5
          negative regulation of cornification 1
          positive regulation of cornification 0
          regulation of cornification + 1
Path 2
Term Annotations click to browse term
  biological_process 20014
    developmental process 6812
      anatomical structure development 6256
        tissue development 2094
          epithelium development 1257
            epithelial cell differentiation 707
              epidermal cell differentiation 203
                keratinocyte differentiation 122
                  keratinization 39
                    cornification 5
                      negative regulation of cornification 1
                      positive regulation of cornification 0
                      regulation of cornification + 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.