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ONTOLOGY REPORT - ANNOTATIONS


Term:cornification
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Accession:GO:0070268 term browser browse the term
Definition:A type of programmed cell death that occurs in the epidermis, morphologically and biochemically distinct from apoptosis. It leads to the formation of corneocytes, i.e. dead keratinocytes containing an amalgam of specific proteins (e.g., keratin, loricrin, SPR and involucrin) and lipids (e.g., fatty acids and ceramides), which are necessary for the function of the cornified skin layer (mechanical resistance, elasticity, water repellence and structural stability).


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cornification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CERS3 ceramide synthase 3 ISO (MGI:MGI:5303015|PMID:22038835) UniProt PMID:22038835 MGI:MGI:5303015 NCBI chr15:79,128,338...79,272,018
Ensembl chr15:98,422,256...98,521,775
JBrowse link
G CYP26B1 cytochrome P450 family 26 subfamily B member 1 ISO (MGI:MGI:5466369|PMID:22366455) MGI PMID:22366455 MGI:MGI:5466369 NCBI chr2A:72,172,658...72,191,410
Ensembl chr2A:73,670,830...73,686,433
JBrowse link
G TMEM79 transmembrane protein 79 ISO (MGI:MGI:5519142|PMID:24084074) MGI PMID:24084074 MGI:MGI:5519142 NCBI chr 1:131,625,864...131,635,370
Ensembl chr 1:135,455,766...135,465,426
JBrowse link
negative regulation of cornification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDSN corneodesmosin ISO (PMID:26014679) CAFA PMID:26014679 NCBI chr 6:30,861,199...30,867,082
Ensembl chr 6:31,727,090...31,731,976
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12561
    multicellular organismal process 6470
      keratinization 13
        cornification 4
          negative regulation of cornification 1
          positive regulation of cornification 0
          regulation of cornification + 1
Path 2
Term Annotations click to browse term
  biological_process 12561
    developmental process 5839
      anatomical structure development 5452
        tissue development 1920
          epithelium development 1177
            epithelial cell differentiation 643
              epidermal cell differentiation 171
                keratinocyte differentiation 97
                  keratinization 13
                    cornification 4
                      negative regulation of cornification 1
                      positive regulation of cornification 0
                      regulation of cornification + 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.