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ONTOLOGY REPORT - ANNOTATIONS


Term:cornification
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Accession:GO:0070268 term browser browse the term
Definition:A type of programmed cell death that occurs in the epidermis, morphologically and biochemically distinct from apoptosis. It leads to the formation of corneocytes, i.e. dead keratinocytes containing an amalgam of specific proteins (e.g., keratin, loricrin, SPR and involucrin) and lipids (e.g., fatty acids and ceramides), which are necessary for the function of the cornified skin layer (mechanical resistance, elasticity, water repellence and structural stability).


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cornification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP14 caspase 14 IEA InterPro GO_REF:0000002 NCBI chr20:47,060,351...47,067,169
Ensembl chr20:47,062,278...47,065,001
JBrowse link
G CERS3 ceramide synthase 3 IEA Ensembl GO_REF:0000107 NCBI chr 3:40,448,174...40,570,736
Ensembl chr 3:40,459,162...40,568,272
JBrowse link
G CYP26B1 cytochrome P450 family 26 subfamily B member 1 IEA Ensembl GO_REF:0000107 NCBI chr17:50,633,397...50,653,882
Ensembl chr17:50,633,413...50,653,894
JBrowse link
G TMEM79 transmembrane protein 79 IEA Ensembl GO_REF:0000107 NCBI chr 7:41,591,332...41,597,993
Ensembl chr 7:41,591,848...41,595,816
JBrowse link
negative regulation of cornification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDSN corneodesmosin ISO (PMID:26014679) CAFA PMID:26014679 NCBI chr12:819,488...824,015
Ensembl chr12:820,467...823,986
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16187
    multicellular organismal process 7605
      keratinization 15
        cornification 5
          negative regulation of cornification 1
          positive regulation of cornification 0
          regulation of cornification + 1
Path 2
Term Annotations click to browse term
  biological_process 16187
    developmental process 6309
      anatomical structure development 5857
        tissue development 2019
          epithelium development 1208
            epithelial cell differentiation 670
              epidermal cell differentiation 175
                keratinocyte differentiation 97
                  keratinization 15
                    cornification 5
                      negative regulation of cornification 1
                      positive regulation of cornification 0
                      regulation of cornification + 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.