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ONTOLOGY REPORT - ANNOTATIONS


Term:cornification
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Accession:GO:0070268 term browser browse the term
Definition:A type of programmed cell death that occurs in the epidermis, morphologically and biochemically distinct from apoptosis. It leads to the formation of corneocytes, i.e. dead keratinocytes containing an amalgam of specific proteins (e.g., keratin, loricrin, SPR and involucrin) and lipids (e.g., fatty acids and ceramides), which are necessary for the function of the cornified skin layer (mechanical resistance, elasticity, water repellence and structural stability).


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cornification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp14 caspase 14 IEA UniProtKB GO_REF:0000002, MGI:MGI:2152098 NCBI chr10:78,711,995...78,718,347
Ensembl chr10:78,711,991...78,718,294
JBrowse link
G Cers3 ceramide synthase 3 IMP (MGI:MGI:5303015|PMID:22038835) UniProt PMID:22038835 MGI:MGI:5303015 NCBI chr 7:66,733,118...66,823,692
Ensembl chr 7:66,743,504...66,823,691
JBrowse link
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 IMP (MGI:MGI:5466369|PMID:22366455) MGI PMID:22366455 MGI:MGI:5466369 NCBI chr 6:84,571,414...84,593,908
Ensembl chr 6:84,571,414...84,593,908
JBrowse link
G Tmem79 transmembrane protein 79 IMP (MGI:MGI:5519142|PMID:24084074) MGI PMID:24084074 MGI:MGI:5519142 NCBI chr 3:88,328,653...88,334,433
Ensembl chr 3:88,328,655...88,336,148
JBrowse link
negative regulation of cornification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdsn corneodesmosin ISO (PMID:26014679) CAFA PMID:26014679 NCBI chr17:35,543,101...35,557,180
Ensembl chr17:35,552,128...35,557,180
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 23392
    multicellular organismal process 8879
      keratinization 37
        cornification 5
          negative regulation of cornification 1
          positive regulation of cornification 0
          regulation of cornification + 1
Path 2
Term Annotations click to browse term
  biological_process 23392
    developmental process 7030
      anatomical structure development 6504
        tissue development 2139
          epithelium development 1269
            epithelial cell differentiation 711
              epidermal cell differentiation 203
                keratinocyte differentiation 122
                  keratinization 37
                    cornification 5
                      negative regulation of cornification 1
                      positive regulation of cornification 0
                      regulation of cornification + 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.