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ONTOLOGY REPORT - ANNOTATIONS


Term:cornification
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Accession:GO:0070268 term browser browse the term
Definition:A type of programmed cell death that occurs in the epidermis, morphologically and biochemically distinct from apoptosis. It leads to the formation of corneocytes, i.e. dead keratinocytes containing an amalgam of specific proteins (e.g., keratin, loricrin, SPR and involucrin) and lipids (e.g., fatty acids and ceramides), which are necessary for the function of the cornified skin layer (mechanical resistance, elasticity, water repellence and structural stability).


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cornification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP14 caspase 14 IEA InterPro GO_REF:0000002 NCBI chr 2:62,522,294...62,531,594
Ensembl chr 2:62,521,997...62,531,539
JBrowse link
G CERS3 ceramide synthase 3 IEA Ensembl GO_REF:0000107 NCBI chr 1:139,027,604...139,154,830
Ensembl chr 1:139,030,642...139,136,874
JBrowse link
G LOC100521659 cytochrome P450 26B1 IEA Ensembl GO_REF:0000107 NCBI chr 3:70,573,551...70,593,416
Ensembl chr 3:70,572,197...70,593,408
JBrowse link
G TMEM79 transmembrane protein 79 IEA Ensembl GO_REF:0000107 NCBI chr 4:93,762,176...93,768,840
Ensembl chr 4:93,762,177...93,768,633
JBrowse link
negative regulation of cornification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDSN corneodesmosin ISO (PMID:26014679) CAFA PMID:26014679 NCBI chr 7:23,520,142...23,524,372
Ensembl chr 7:23,520,142...23,524,372
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16545
    multicellular organismal process 8037
      keratinization 13
        cornification 5
          negative regulation of cornification 1
          positive regulation of cornification 0
          regulation of cornification + 1
Path 2
Term Annotations click to browse term
  biological_process 16545
    developmental process 6302
      anatomical structure development 5842
        tissue development 2015
          epithelium development 1209
            epithelial cell differentiation 664
              epidermal cell differentiation 170
                keratinocyte differentiation 94
                  keratinization 13
                    cornification 5
                      negative regulation of cornification 1
                      positive regulation of cornification 0
                      regulation of cornification + 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.