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ONTOLOGY REPORT - ANNOTATIONS


Term:cornification
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Accession:GO:0070268 term browser browse the term
Definition:A type of programmed cell death that occurs in the epidermis, morphologically and biochemically distinct from apoptosis. It leads to the formation of corneocytes, i.e. dead keratinocytes containing an amalgam of specific proteins (e.g., keratin, loricrin, SPR and involucrin) and lipids (e.g., fatty acids and ceramides), which are necessary for the function of the cornified skin layer (mechanical resistance, elasticity, water repellence and structural stability).


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cornification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cers3 ceramide synthase 3 ISO (MGI:MGI:5303015|PMID:22038835) UniProt PMID:22038835 MGI:MGI:5303015 NCBI chrNW_004936483:3,276,519...3,365,054 JBrowse link
G LOC101975674 cytochrome P450 26B1 ISO (MGI:MGI:5466369|PMID:22366455) MGI PMID:22366455 MGI:MGI:5466369 NCBI chrNW_004936491:16,010,394...16,028,852 JBrowse link
G Tmem79 transmembrane protein 79 ISO (MGI:MGI:5519142|PMID:24084074) MGI PMID:24084074 MGI:MGI:5519142 NCBI chrNW_004936580:5,519,577...5,525,608 JBrowse link
negative regulation of cornification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdsn corneodesmosin ISO (PMID:26014679) CAFA PMID:26014679 NCBI chrNW_004936837:787,035...791,388 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11998
    multicellular organismal process 6221
      keratinization 11
        cornification 4
          negative regulation of cornification 1
          positive regulation of cornification 0
          regulation of cornification + 1
Path 2
Term Annotations click to browse term
  biological_process 11998
    developmental process 5648
      anatomical structure development 5286
        tissue development 1870
          epithelium development 1139
            epithelial cell differentiation 624
              epidermal cell differentiation 164
                keratinocyte differentiation 91
                  keratinization 11
                    cornification 4
                      negative regulation of cornification 1
                      positive regulation of cornification 0
                      regulation of cornification + 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.