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ONTOLOGY REPORT - ANNOTATIONS


Term:pyroptosis
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Accession:GO:0070269 term browser browse the term
Definition:A caspase-1-dependent cell death subroutine that is associated with the generation of pyrogenic mediators such as IL-1beta and IL-18.


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pyroptosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aim2 absent in melanoma 2 ISO (MGI:MGI:3839523|PMID:19158676)
(PMID:19158675), (PMID:19158676)
RGD PMID:19158675, PMID:19158676 MGI:MGI:3839523 NCBI chr13:91,919,834...91,963,080
Ensembl chr13:91,954,138...91,962,588
JBrowse link
G Apip APAF1 interacting protein ISO (PMID:24367089) RGD PMID:24367089 NCBI chr 3:92,969,128...92,998,104
Ensembl chr 3:92,969,141...92,995,483
JBrowse link
G Casp1 caspase 1 ISO
ISS
IEA
MGI:MGI:2158744 (MGI:MGI:5468674|PMID:22002608)
GO_REF:0000024
(PMID:32109412), (PMID:32553275)
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:22002608, PMID:32109412, PMID:32553275 GO_REF:0000024, GO_REF:0000107, MGI:MGI:5468674 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp4 caspase 4 ISO (PMID:32109412)
MGI:MGI:5468949 (MGI:MGI:5468674|PMID:22002608), (MGI:MGI:6467703|PMID:32109412)
RGD PMID:22002608, PMID:32109412 MGI:MGI:5468674, MGI:MGI:6467703 NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652
JBrowse link
G Casp8 caspase 8 ISS
ISO
GO_REF:0000024
(MGI:MGI:6270017|PMID:30361383), (MGI:MGI:6401035|PMID:31748744)
UniProt
RGD
PMID:30361383, PMID:31748744 GO_REF:0000024, MGI:MGI:6270017, MGI:MGI:6401035 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Dhx9 DExH-box helicase 9 ISO (MGI:MGI:5908739|PMID:28636595) RGD PMID:28636595 MGI:MGI:5908739 NCBI chr13:70,885,503...70,922,278
Ensembl chr13:70,885,504...70,922,245
JBrowse link
G Gsdma gasdermin A IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:86,569,898...86,595,102
Ensembl chr10:86,582,612...86,595,102
JBrowse link
G Gsdmc gasdermin C IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:104,474,418...104,492,373
Ensembl chr 7:104,474,418...104,486,710
JBrowse link
G Gsdmd gasdermin D IBA
ISO
PMID:21873635
(MGI:MGI:5751630|PMID:26611636), (MGI:MGI:5789813|PMID:27339137), (MGI:MGI:5796057|PMID:27383986), (MGI:MGI:6467699|PMID:29576317), (MGI:MGI:6467703|PMID:32109412), (MGI:MGI:6467707|PMID:32553275), (MGI:MGI:6467712|PMID:32820063)
(PMID:28392147), (PMID:30361383), (PMID:32109412), (PMID:32820063)
RGD PMID:26611636, PMID:27339137, PMID:27383986, PMID:28392147, PMID:29576317, PMID:30361383, PMID:32109412, PMID:32553275, PMID:32820063, PMID:21873635 MGI:MGI:5751630, MGI:MGI:5789813, MGI:MGI:5796057, MGI:MGI:6467699, MGI:MGI:6467703, MGI:MGI:6467707, MGI:MGI:6467712, RGD:13792537 NCBI chr 7:116,889,147...116,894,134
Ensembl chr 7:116,889,572...116,894,134
JBrowse link
G Gsdme gasdermin E ISO (PMID:28459430), (PMID:31953257), (PMID:32188940) RGD PMID:28459430, PMID:31953257, PMID:32188940 NCBI chr 4:79,934,075...79,999,678
Ensembl chr 4:79,934,887...79,989,572
JBrowse link
G Gzma granzyme A ISO (PMID:32299851) RGD PMID:32299851 NCBI chr 2:44,968,846...44,981,436
Ensembl chr 2:44,968,765...44,981,458
JBrowse link
G Gzmb granzyme B ISO
ISS
(PMID:32188940)
GO_REF:0000024
RGD
UniProt
PMID:32188940 GO_REF:0000024 NCBI chr15:35,413,862...35,417,293
Ensembl chr15:35,413,793...35,417,316
JBrowse link
G Gzmbl2 Granzyme B-like 2 ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr15:36,469,318...36,472,393
Ensembl chr15:35,413,793...35,417,316
Ensembl chr15:35,413,793...35,417,316
JBrowse link
G Naip2 NLR family, apoptosis inhibitory protein 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 2:30,376,419...30,458,542 JBrowse link
G Naip6 NLR family, apoptosis inhibitory protein 6 ISO (MGI:MGI:5289703|PMID:21874021) RGD PMID:21874021 MGI:MGI:5289703 NCBI chr 2:30,377,505...30,418,578 JBrowse link
G Nlrc4 NLR family, CARD domain containing 4 ISS
ISO
GO_REF:0000024
(MGI:MGI:3662989|PMID:16648853), (MGI:MGI:3662990|PMID:16648852), (MGI:MGI:5289703|PMID:21874021), (MGI:MGI:5428366|PMID:22484733), (MGI:MGI:5444805|PMID:22885697)
UniProt
RGD
PMID:16648852, PMID:16648853, PMID:21874021, PMID:22484733, PMID:22885697 GO_REF:0000024, MGI:MGI:3662989, MGI:MGI:3662990, MGI:MGI:5289703, MGI:MGI:5428366, MGI:MGI:5444805 NCBI chr 6:22,167,874...22,194,755
Ensembl chr 6:22,167,919...22,194,250
JBrowse link
G Nlrp9 NLR family, pyrin domain containing 9 ISO (MGI:MGI:5908739|PMID:28636595) RGD PMID:28636595 MGI:MGI:5908739 NCBI chr 1:71,859,390...71,917,337
Ensembl chr 1:71,859,390...71,909,138
JBrowse link
G RGD1359449 gasdermin domain containing protein RGD1359449 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:104,500,564...104,511,236
Ensembl chr 7:104,501,014...104,511,234
JBrowse link
G Zbp1 Z-DNA binding protein 1 ISS
ISO
GO_REF:0000024
(MGI:MGI:6442612|PMID:27917412)
UniProt
RGD
PMID:27917412 GO_REF:0000024, MGI:MGI:6442612 NCBI chr 3:171,276,062...171,292,062
Ensembl chr 3:171,276,062...171,286,537
JBrowse link
cytotoxic T cell pyroptotic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gzma granzyme A ISO (PMID:32299851) RGD PMID:32299851 NCBI chr 2:44,968,846...44,981,436
Ensembl chr 2:44,968,765...44,981,458
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    cellular process 18792
      cell death 2144
        programmed cell death 1955
          pyroptosis 19
            cytotoxic T cell pyroptotic process 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.