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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of stress-activated protein kinase signaling cascade
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Accession:GO:0070303 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade.
Synonyms:exact_synonym: down regulation of stress-activated protein kinase signaling pathway;   downregulation of stress-activated protein kinase signaling pathway;   negative regulation of SAPK signaling pathway;   negative regulation of stress-activated protein kinase signaling pathway;   negative regulation of stress-activated protein kinase signalling pathway
 narrow_synonym: inhibition of stress-activated protein kinase signaling pathway


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negative regulation of JNK cascade term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aida axin interactor, dorsalization associated ISO (MGI:MGI:3799599|PMID:17681137) UniProtKB PMID:17681137 MGI:MGI:3799599 NCBI chrNW_004955520:1,819,617...1,851,273 JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO RGD PMID:17064355 RGD:2298577 NCBI chrNW_004955538:3,208,711...3,224,386 JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 ISO (MGI:MGI:3693042|PMID:17081782) MGI PMID:17081782 MGI:MGI:3693042 NCBI chrNW_004955555:426,894...446,235 JBrowse link
G Cyld CYLD lysine 63 deubiquitinase ISO (PMID:29291351)
(MGI:MGI:6162308|PMID:29291351)
UniProtKB PMID:29291351 MGI:MGI:6162308 NCBI chrNW_004955433:8,788,867...8,845,925 JBrowse link
G Dact1 dishevelled binding antagonist of beta catenin 1 ISO (MGI:MGI:5437437|PMID:17197390)
(PMID:17197390)
UniProtKB PMID:17197390 MGI:MGI:5437437 NCBI chrNW_004955466:12,367,760...12,374,141 JBrowse link
G Dusp10 dual specificity phosphatase 10 ISO (PMID:10391943)
(MGI:MGI:3051749|PMID:15306813)
BHF-UCL
MGI
PMID:10391943, PMID:15306813 MGI:MGI:3051749 NCBI chrNW_004955520:2,338,548...2,371,591 JBrowse link
G Dusp19 dual specificity phosphatase 19 ISO (MGI:MGI:2182169|PMID:11959862) BHF-UCL PMID:11959862 MGI:MGI:2182169 NCBI chrNW_004955403:14,421,057...14,439,829 JBrowse link
G Dusp3 dual specificity phosphatase 3 ISO (PMID:11085983)
(PMID:19010898)
UniProtKB PMID:11085983, PMID:19010898 NCBI chrNW_004955451:17,064,739...17,069,964 JBrowse link
G F2rl1 F2R like trypsin receptor 1 ISO (PMID:19781631) UniProtKB PMID:19781631 NCBI chrNW_004955425:24,050,901...24,054,039 JBrowse link
G Fktn fukutin ISO (PMID:18808525) BHF-UCL PMID:18808525 NCBI chrNW_004955419:20,933,662...20,994,793 JBrowse link
G Gps2 G protein pathway suppressor 2 ISO (PMID:11931768)
(MGI:MGI:6148454|PMID:22424771)
UniProtKB PMID:11931768, PMID:22424771 MGI:MGI:6148454 NCBI chrNW_004955467:9,600,829...9,604,148 JBrowse link
G Hdac3 histone deacetylase 3 ISO (PMID:11931768) UniProtKB PMID:11931768 NCBI chrNW_004955415:12,138,520...12,154,234 JBrowse link
G Itch itchy E3 ubiquitin protein ligase ISO (MGI:MGI:3774677|PMID:18246070) BHF-UCL PMID:18246070 MGI:MGI:3774677 NCBI chrNW_004955422:26,810,829...26,918,517 JBrowse link
G Klhl31 kelch like family member 31 ISO (PMID:18719355) UniProt PMID:18719355 NCBI chrNW_004955411:2,449,241...2,461,779 JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 ISO RGD PMID:12064607 RGD:1299562 NCBI chrNW_004955422:2,064,010...2,081,681 JBrowse link
G Mecom MDS1 and EVI1 complex locus ISO (PMID:10856240) UniProtKB PMID:10856240 NCBI chrNW_004955448:18,259,847...18,542,085 JBrowse link
G Men1 menin 1 ISO (PMID:12226747) UniProtKB PMID:12226747 NCBI chrNW_004955422:20,356,491...20,363,374 JBrowse link
G Ncor1 nuclear receptor corepressor 1 ISO (PMID:11931768) UniProtKB PMID:11931768 NCBI chrNW_004955467:1,408,292...1,568,539 JBrowse link
G Pafah1b1 platelet activating factor acetylhydrolase 1b regulatory subunit 1 ISO (MGI:MGI:5308511|PMID:22073305) MGI PMID:22073305 MGI:MGI:5308511 NCBI chrNW_004955481:608,897...686,454 JBrowse link
G Per1 period circadian regulator 1 ISO PMID:24447840 UniProt PMID:24447840 RGD:8655527 NCBI chrNW_004955467:8,798,436...8,813,369 JBrowse link
G Sfrp4 secreted frizzled related protein 4 ISO RGD PMID:18567805 RGD:4107045 NCBI chrNW_004955460:5,654,187...5,666,475 JBrowse link
G Sh3rf2 SH3 domain containing ring finger 2 ISO PMID:22128169 UniProt PMID:22128169 RGD:13673844 NCBI chrNW_004955415:8,024,984...8,148,970 JBrowse link
G Sirpa signal regulatory protein alpha ISO (MGI:MGI:3760575|PMID:17954568) ARUK-UCL PMID:17954568 MGI:MGI:3760575 NCBI chrNW_004955415:13,030,752...13,072,735 JBrowse link
G Taok3 TAO kinase 3 ISO (PMID:10559204) HGNC PMID:10559204 NCBI chrNW_004955455:13,020,618...13,207,539 JBrowse link
G Zmynd11 zinc finger MYND-type containing 11 ISO (PMID:20732415) UniProtKB PMID:20732415 NCBI chrNW_004955492:775,501...879,051 JBrowse link
negative regulation of JUN kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aida axin interactor, dorsalization associated ISO (PMID:17681137)
(MGI:MGI:3799599|PMID:17681137)
MGI PMID:17681137 MGI:MGI:3799599 NCBI chrNW_004955520:1,819,617...1,851,273 JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 ISO (PMID:24512202) UniProtKB PMID:24512202 NCBI chrNW_004955472:2,604,002...2,618,033 JBrowse link
G Dusp10 dual specificity phosphatase 10 ISO (PMID:10391943)
(MGI:MGI:3051749|PMID:15306813)
BHF-UCL
MGI
PMID:10391943, PMID:15306813 MGI:MGI:3051749 NCBI chrNW_004955520:2,338,548...2,371,591 JBrowse link
G Dusp19 dual specificity phosphatase 19 ISO (MGI:MGI:2182169|PMID:11959862) BHF-UCL PMID:11959862 MGI:MGI:2182169 NCBI chrNW_004955403:14,421,057...14,439,829 JBrowse link
G Gstp1 glutathione S-transferase pi 1 ISO (PMID:16636664)
(MGI:MGI:5009198|PMID:10945608), (MGI:MGI:5009411|PMID:16023107)
(MGI:MGI:3721484|PMID:12646564)
BHF-UCL PMID:10945608, PMID:12646564, PMID:16023107, PMID:16636664 MGI:MGI:3721484, MGI:MGI:5009198, MGI:MGI:5009411 NCBI chrNW_004955422:17,914,228...17,916,918 JBrowse link
G Hipk3 homeodomain interacting protein kinase 3 ISO (MGI:MGI:1913166|PMID:11034606) UniProtKB PMID:11034606 MGI:MGI:1913166 NCBI chrNW_004955422:12,841,781...12,928,194 JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 ISO PMID:21076496 RGD
UniProt
PMID:12064607, PMID:21076496 RGD:1299562, RGD:13673827 NCBI chrNW_004955422:2,064,010...2,081,681 JBrowse link
G Nppa natriuretic peptide A ISO (PMID:22399583) UniProt PMID:22399583 NCBI chrNW_004955486:2,061,196...2,062,805 JBrowse link
G Ptpn22 protein tyrosine phosphatase non-receptor type 22 ISO (PMID:23991106) UniProtKB PMID:23991106 NCBI chrNW_004955435:17,082,762...17,139,067 JBrowse link
G Sfrp1 secreted frizzled related protein 1 ISO (MGI:MGI:3839161|PMID:19300477) MGI PMID:19300477 MGI:MGI:3839161 NCBI chrNW_004955536:1,663,721...1,702,678 JBrowse link
G Sfrp2 secreted frizzled related protein 2 ISO (MGI:MGI:3839161|PMID:19300477) MGI PMID:19300477 MGI:MGI:3839161 NCBI chrNW_004955471:8,103,937...8,112,596 JBrowse link
G Sfrp5 secreted frizzled related protein 5 ISO (MGI:MGI:3839161|PMID:19300477) MGI PMID:19300477 MGI:MGI:3839161 NCBI chrNW_004955507:3,836,607...3,841,910 JBrowse link
G Tp73 tumor protein p73 ISO (MGI:MGI:3574697|PMID:15483136) MGI PMID:15483136 MGI:MGI:3574697 NCBI chrNW_004955486:7,914,608...7,961,992 JBrowse link
negative regulation of p38MAPK cascade term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyld CYLD lysine 63 deubiquitinase ISO (PMID:29291351)
(MGI:MGI:6162308|PMID:29291351)
UniProtKB PMID:29291351 MGI:MGI:6162308 NCBI chrNW_004955433:8,788,867...8,845,925 JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 ISO (PMID:20551903) UniProtKB PMID:20551903 NCBI chrNW_004955420:13,068,289...13,273,805 JBrowse link
G Dusp1 dual specificity phosphatase 1 ISO (PMID:22991462) BHF-UCL PMID:22991462 NCBI chrNW_004955408:25,481,294...25,484,381 JBrowse link
G Dusp10 dual specificity phosphatase 10 ISO (PMID:10391943) BHF-UCL PMID:10391943 NCBI chrNW_004955520:2,338,548...2,371,591 JBrowse link
G Ezr ezrin ISO (PMID:20551903) UniProtKB PMID:20551903 NCBI chrNW_004955439:3,701,722...3,740,345 JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 ISO (MGI:MGI:3822965|PMID:18681888) MGI PMID:18681888 MGI:MGI:3822965 NCBI chrNW_004955431:14,680,364...14,706,182 JBrowse link
G Ptpn22 protein tyrosine phosphatase non-receptor type 22 ISO (PMID:23991106)
(MGI:MGI:5640942|PMID:23991106)
UniProtKB PMID:23991106 MGI:MGI:5640942 NCBI chrNW_004955435:17,082,762...17,139,067 JBrowse link
negative regulation of stress-activated MAPK cascade term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dusp10 dual specificity phosphatase 10 ISO (MGI:MGI:4366202|PMID:19696743) MGI PMID:19696743 MGI:MGI:4366202 NCBI chrNW_004955520:2,338,548...2,371,591 JBrowse link
G Foxm1 forkhead box M1 ISO (PMID:19696738) BHF-UCL PMID:19696738 NCBI chrNW_004955429:18,392,545...18,405,254 JBrowse link
G Foxo1 forkhead box O1 ISO (PMID:19696738) BHF-UCL PMID:19696738 NCBI chrNW_004955431:5,797,359...5,890,758 JBrowse link
G Gstp1 glutathione S-transferase pi 1 ISO (MGI:MGI:5009411|PMID:16023107) BHF-UCL PMID:16023107 MGI:MGI:5009411 NCBI chrNW_004955422:17,914,228...17,916,918 JBrowse link
G Igbp1 immunoglobulin binding protein 1 ISO (PMID:17438131) UniProtKB PMID:17438131 NCBI chrNW_004955475:9,671,162...9,694,926 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor ISO (PMID:19545562) UniProtKB PMID:19545562 NCBI chrNW_004955461:2,714,022...2,718,872 JBrowse link
G Pbk PDZ binding kinase ISO (MGI:MGI:5293269|PMID:21715333) MGI PMID:21715333 MGI:MGI:5293269 NCBI chrNW_004955403:50,332,167...50,353,147 JBrowse link
G Ppia peptidylprolyl isomerase A ISO (PMID:26095851) UniProt PMID:26095851 NCBI chrNW_004955456:7,381,923...7,383,203 JBrowse link
G Qars1 glutaminyl-tRNA synthetase 1 ISO (PMID:11096076) CAFA PMID:11096076 NCBI chrNW_004955532:1,093,444...1,100,591 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11857
    response to stimulus 6353
      response to stress 3035
        cellular response to stress 1648
          stress-activated protein kinase signaling cascade 252
            negative regulation of stress-activated protein kinase signaling cascade 45
              negative regulation of stress-activated MAPK cascade + 45
Path 2
Term Annotations click to browse term
  biological_process 11857
    biological regulation 8688
      regulation of biological process 8250
        regulation of cellular process 7832
          signal transduction 3673
            intracellular signal transduction 1974
              stress-activated protein kinase signaling cascade 252
                regulation of stress-activated protein kinase signaling cascade 223
                  negative regulation of stress-activated protein kinase signaling cascade 45
                    negative regulation of stress-activated MAPK cascade + 45
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.