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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of stress-activated protein kinase signaling cascade
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Accession:GO:0070303 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade.
Synonyms:exact_synonym: down regulation of stress-activated protein kinase signaling pathway;   downregulation of stress-activated protein kinase signaling pathway;   negative regulation of SAPK signaling pathway;   negative regulation of stress-activated protein kinase signaling pathway;   negative regulation of stress-activated protein kinase signalling pathway
 narrow_synonym: inhibition of stress-activated protein kinase signaling pathway


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negative regulation of JNK cascade term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AIDA axin interactor, dorsalization associated ISO (MGI:MGI:3799599|PMID:17681137) UniProtKB PMID:17681137 MGI:MGI:3799599 NCBI chr38:16,938,279...16,971,200
Ensembl chr38:16,939,556...16,971,200
JBrowse link
G AKT1 AKT serine/threonine kinase 1 ISO RGD PMID:17064355 RGD:2298577 NCBI chr 8:72,317,399...72,335,686
Ensembl chr 8:72,317,869...72,335,193
JBrowse link
G CEACAM1 CEA cell adhesion molecule 1 ISO (MGI:MGI:3693042|PMID:17081782) MGI PMID:17081782 MGI:MGI:3693042 NCBI chr 1:111,902,429...111,919,191
Ensembl chr 1:111,745,413...111,917,830
JBrowse link
G CYLD CYLD lysine 63 deubiquitinase IEA Ensembl GO_REF:0000107 NCBI chr 2:64,561,684...64,628,829
Ensembl chr 2:64,562,503...64,628,175
JBrowse link
G DACT1 dishevelled binding antagonist of beta catenin 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 8:33,950,016...33,959,671
Ensembl chr 8:33,949,926...33,958,449
JBrowse link
G DUSP10 dual specificity phosphatase 10 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr38:16,196,354...16,233,640
Ensembl chr38:16,196,635...16,231,315
JBrowse link
G DUSP19 dual specificity phosphatase 19 ISO (MGI:MGI:2182169|PMID:11959862) BHF-UCL PMID:11959862 MGI:MGI:2182169 NCBI chr36:26,095,436...26,111,700
Ensembl chr36:26,095,463...26,111,774
JBrowse link
G DUSP3 dual specificity phosphatase 3 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:19,518,302...19,531,000
Ensembl chr 9:19,518,746...19,527,624
JBrowse link
G F2RL1 F2R like trypsin receptor 1 IEA Ensembl GO_REF:0000107 NCBI chr 3:29,801,119...29,810,006
Ensembl chr 3:29,800,211...29,810,180
JBrowse link
G FKTN fukutin IEA Ensembl GO_REF:0000107 NCBI chr11:61,394,002...61,462,056
Ensembl chr11:61,405,034...61,461,396
JBrowse link
G GPS2 G protein pathway suppressor 2 IEA Ensembl GO_REF:0000107 NCBI chr 5:32,273,169...32,275,915
Ensembl chr 5:32,273,173...32,275,580
JBrowse link
G HDAC3 histone deacetylase 3 IEA Ensembl GO_REF:0000107 NCBI chr 2:36,583,283...36,598,121
Ensembl chr 2:36,583,283...36,597,682
JBrowse link
G ITCH itchy E3 ubiquitin protein ligase IEA Ensembl GO_REF:0000107 NCBI chr24:23,476,619...23,630,574
Ensembl chr24:23,476,736...23,627,469
JBrowse link
G KLHL31 kelch like family member 31 IEA Ensembl GO_REF:0000107 NCBI chr12:21,153,843...21,201,345
Ensembl chr12:21,156,440...21,160,527
JBrowse link
G MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 ISO RGD PMID:12064607 RGD:1299562 NCBI chr18:43,517,186...43,522,603
Ensembl chr18:43,517,677...43,526,379
JBrowse link
G MARVELD3 MARVEL domain containing 3 IEA Ensembl GO_REF:0000107 NCBI chr 5:77,412,353...77,421,032
Ensembl chr 5:77,412,101...77,425,578
JBrowse link
G MECOM MDS1 and EVI1 complex locus IEA Ensembl GO_REF:0000107 NCBI chr34:33,747,495...34,299,389
Ensembl chr34:33,748,843...34,299,276
JBrowse link
G MEN1 menin 1 IEA Ensembl GO_REF:0000107 NCBI chr18:52,346,747...52,352,884
Ensembl chr18:52,346,933...52,353,340
JBrowse link
G NCOR1 nuclear receptor corepressor 1 IEA Ensembl GO_REF:0000107 NCBI chr 5:39,687,530...39,837,003
Ensembl chr 5:39,687,543...39,836,464
JBrowse link
G PAFAH1B1 platelet activating factor acetylhydrolase 1b regulatory subunit 1 IEA Ensembl GO_REF:0000107 NCBI chr 9:46,648,057...46,731,259
Ensembl chr 9:46,648,052...46,771,400
JBrowse link
G PER1 period circadian regulator 1 ISO PMID:24447840 UniProt PMID:24447840 RGD:8655527 NCBI chr 5:32,957,517...32,972,368
Ensembl chr 5:32,957,127...32,968,465
JBrowse link
G SFRP4 secreted frizzled related protein 4 ISO RGD PMID:18567805 RGD:4107045 NCBI chr18:12,018,049...12,028,123
Ensembl chr18:12,017,978...12,027,788
JBrowse link
G SH3RF2 SH3 domain containing ring finger 2 ISO PMID:22128169 UniProt PMID:22128169 RGD:13673844 NCBI chr 2:40,380,313...40,514,211
Ensembl chr 2:40,380,218...40,510,853
JBrowse link
G SIRPA signal regulatory protein alpha ISO (MGI:MGI:3760575|PMID:17954568) ARUK-UCL PMID:17954568 MGI:MGI:3760575 NCBI chr24:19,094,930...19,136,655 JBrowse link
G TAOK3 TAO kinase 3 IEA Ensembl GO_REF:0000107 NCBI chr26:14,534,083...14,712,779
Ensembl chr26:14,534,901...14,631,899
JBrowse link
G ZMYND11 zinc finger MYND-type containing 11 IEA Ensembl GO_REF:0000107 NCBI chr 2:34,492,283...34,614,152
Ensembl chr 2:34,493,994...34,570,523
JBrowse link
negative regulation of JUN kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AIDA axin interactor, dorsalization associated IEA Ensembl GO_REF:0000107 NCBI chr38:16,938,279...16,971,200
Ensembl chr38:16,939,556...16,971,200
JBrowse link
G DNAJA1 DnaJ heat shock protein family (Hsp40) member A1 IEA Ensembl GO_REF:0000107 NCBI chr11:50,156,089...50,168,379
Ensembl chr11:50,156,089...50,167,536
JBrowse link
G DUSP10 dual specificity phosphatase 10 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr38:16,196,354...16,233,640
Ensembl chr38:16,196,635...16,231,315
JBrowse link
G DUSP19 dual specificity phosphatase 19 ISO (MGI:MGI:2182169|PMID:11959862) BHF-UCL PMID:11959862 MGI:MGI:2182169 NCBI chr36:26,095,436...26,111,700
Ensembl chr36:26,095,463...26,111,774
JBrowse link
G GSTP1 glutathione S-transferase pi 1 ISO (MGI:MGI:5009198|PMID:10945608), (MGI:MGI:5009411|PMID:16023107)
(MGI:MGI:3721484|PMID:12646564)
(PMID:16636664)
BHF-UCL PMID:10945608, PMID:12646564, PMID:16023107, PMID:16636664 MGI:MGI:3721484, MGI:MGI:5009198, MGI:MGI:5009411 NCBI chr18:49,905,161...49,908,182
Ensembl chr18:49,905,161...49,908,182
JBrowse link
G HIPK3 homeodomain interacting protein kinase 3 IEA Ensembl GO_REF:0000107 NCBI chr18:34,305,208...34,397,593
Ensembl chr18:34,308,584...34,397,511
JBrowse link
G MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 ISO PMID:21076496 UniProt
RGD
PMID:12064607, PMID:21076496 RGD:1299562, RGD:13673827 NCBI chr18:43,517,186...43,522,603
Ensembl chr18:43,517,677...43,526,379
JBrowse link
G NPPA natriuretic peptide A ISO (PMID:22399583) UniProt PMID:22399583 NCBI chr 2:84,406,317...84,408,115
Ensembl chr 2:84,396,073...84,408,385
JBrowse link
G PTPN22 protein tyrosine phosphatase non-receptor type 22 ISO (PMID:23991106) UniProtKB PMID:23991106 NCBI chr17:51,623,628...51,683,039
Ensembl chr17:51,623,623...51,682,858
JBrowse link
G SFRP1 secreted frizzled related protein 1 ISO (MGI:MGI:3839161|PMID:19300477) MGI PMID:19300477 MGI:MGI:3839161 NCBI chr16:24,262,451...24,306,162
Ensembl chr16:24,261,946...24,302,964
JBrowse link
G SFRP2 secreted frizzled related protein 2 IEA Ensembl GO_REF:0000107 NCBI chr15:51,541,197...51,548,765
Ensembl chr15:51,540,500...51,548,765
JBrowse link
G SFRP5 secreted frizzled related protein 5 ISO (MGI:MGI:3839161|PMID:19300477) MGI PMID:19300477 MGI:MGI:3839161 NCBI chr28:10,994,180...10,999,552
Ensembl chr28:10,993,930...10,999,564
JBrowse link
G TP73 tumor protein p73 ISO (MGI:MGI:3574697|PMID:15483136) MGI PMID:15483136 MGI:MGI:3574697 NCBI chr 5:58,194,385...58,241,159
Ensembl chr 5:58,187,826...58,240,839
JBrowse link
negative regulation of p38MAPK cascade term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYLD CYLD lysine 63 deubiquitinase IEA Ensembl GO_REF:0000107 NCBI chr 2:64,561,684...64,628,829
Ensembl chr 2:64,562,503...64,628,175
JBrowse link
G DLG1 discs large MAGUK scaffold protein 1 IEA Ensembl GO_REF:0000107 NCBI chr33:30,016,323...30,253,180
Ensembl chr33:30,016,600...30,253,547
JBrowse link
G DUSP1 dual specificity phosphatase 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 4:39,588,833...39,591,065
Ensembl chr 4:39,588,339...39,590,514
JBrowse link
G DUSP10 dual specificity phosphatase 10 IEA Ensembl GO_REF:0000107 NCBI chr38:16,196,354...16,233,640
Ensembl chr38:16,196,635...16,231,315
JBrowse link
G EZR ezrin IEA Ensembl GO_REF:0000107 NCBI chr 1:48,160,206...48,210,036
Ensembl chr 1:48,160,206...48,210,036
JBrowse link
G HSPH1 heat shock protein family H (Hsp110) member 1 ISO (MGI:MGI:3822965|PMID:18681888) MGI PMID:18681888 MGI:MGI:3822965 NCBI chr25:8,972,942...8,998,404
Ensembl chr25:8,972,724...8,997,893
JBrowse link
G PTPN22 protein tyrosine phosphatase non-receptor type 22 IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr17:51,623,628...51,683,039
Ensembl chr17:51,623,623...51,682,858
JBrowse link
negative regulation of stress-activated MAPK cascade term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DUSP10 dual specificity phosphatase 10 ISO (MGI:MGI:4366202|PMID:19696743) MGI PMID:19696743 MGI:MGI:4366202 NCBI chr38:16,196,354...16,233,640
Ensembl chr38:16,196,635...16,231,315
JBrowse link
G FOXM1 forkhead box M1 IEA Ensembl GO_REF:0000107 NCBI chr27:41,894,605...41,905,656
Ensembl chr27:41,894,672...41,905,663
JBrowse link
G FOXO1 forkhead box O1 IEA Ensembl GO_REF:0000107 NCBI chr25:603,433...706,961
Ensembl chr25:603,543...702,825
JBrowse link
G GSTP1 glutathione S-transferase pi 1 ISO (MGI:MGI:5009411|PMID:16023107) BHF-UCL PMID:16023107 MGI:MGI:5009411 NCBI chr18:49,905,161...49,908,182
Ensembl chr18:49,905,161...49,908,182
JBrowse link
G IGBP1 immunoglobulin binding protein 1 ISO (PMID:17438131) UniProtKB PMID:17438131 NCBI chr  X:54,558,515...54,612,029
Ensembl chr  X:54,547,446...54,613,171
JBrowse link
G LOC403581 peptidylprolyl isomerase A (cyclophilin A) pseudogene ISO (PMID:26095851) UniProt PMID:26095851 NCBI chr 7:80,937,433...80,938,175 JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor IMP (PMID:19545562) UniProtKB PMID:19545562 NCBI chr13:25,200,772...25,205,309
Ensembl chr13:25,200,577...25,205,309
JBrowse link
G PBK PDZ binding kinase IEA Ensembl GO_REF:0000107 NCBI chr25:29,751,805...29,781,806
Ensembl chr25:29,751,848...29,781,300
JBrowse link
G QARS1 glutaminyl-tRNA synthetase 1 IEA Ensembl GO_REF:0000107 NCBI chr20:40,077,856...40,085,100
Ensembl chr20:40,078,163...40,085,099
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16162
    response to stimulus 8537
      response to stress 3623
        cellular response to stress 1901
          stress-activated protein kinase signaling cascade 274
            negative regulation of stress-activated protein kinase signaling cascade 46
              negative regulation of stress-activated MAPK cascade + 46
Path 2
Term Annotations click to browse term
  biological_process 16162
    biological regulation 11530
      regulation of biological process 10939
        regulation of cellular process 10481
          signal transduction 5450
            intracellular signal transduction 2482
              stress-activated protein kinase signaling cascade 274
                regulation of stress-activated protein kinase signaling cascade 237
                  negative regulation of stress-activated protein kinase signaling cascade 46
                    negative regulation of stress-activated MAPK cascade + 46
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.