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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of stress-activated protein kinase signaling cascade
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Accession:GO:0070303 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade.
Synonyms:exact_synonym: down regulation of stress-activated protein kinase signaling pathway;   downregulation of stress-activated protein kinase signaling pathway;   negative regulation of SAPK signaling pathway;   negative regulation of stress-activated protein kinase signaling pathway;   negative regulation of stress-activated protein kinase signalling pathway
 narrow_synonym: inhibition of stress-activated protein kinase signaling pathway


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negative regulation of JNK cascade term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AIDA axin interactor, dorsalization associated ISS UniProtKB GO_REF:0000024 NCBI chr 1:222,668,013...222,712,895
Ensembl chr 1:222,668,013...222,713,210
JBrowse link
G AKT1 AKT serine/threonine kinase 1 IEA Ensembl GO_REF:0000107 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G AMBP alpha-1-microglobulin/bikunin precursor TAS (PMID:12817471) UniProtKB PMID:12817471 NCBI chr 9:114,060,127...114,078,300
Ensembl chr 9:114,060,127...114,078,328
JBrowse link
G CEACAM1 CEA cell adhesion molecule 1 ISO (MGI:MGI:3693042|PMID:17081782) MGI PMID:17081782 MGI:MGI:3693042 NCBI chr19:42,507,306...42,528,482
Ensembl chr19:42,507,304...42,561,234
JBrowse link
G CYLD CYLD lysine 63 deubiquitinase IDA (PMID:29291351) UniProtKB PMID:29291351 NCBI chr16:50,742,086...50,801,935
Ensembl chr16:50,742,050...50,801,935
JBrowse link
G DACT1 dishevelled binding antagonist of beta catenin 1 IDA
IBA
(PMID:17197390)
(PMID:21873635)
UniProtKB
GO_Central
PMID:17197390, PMID:21873635 NCBI chr14:58,634,061...58,648,321
Ensembl chr14:58,633,967...58,648,321
JBrowse link
G DUSP10 dual specificity phosphatase 10 IDA
IBA
(PMID:10391943)
(PMID:21873635)
BHF-UCL
GO_Central
PMID:10391943, PMID:21873635 NCBI chr 1:221,701,424...221,742,091
Ensembl chr 1:221,701,424...221,742,089
JBrowse link
G DUSP19 dual specificity phosphatase 19 ISS BHF-UCL GO_REF:0000024 NCBI chr 2:183,078,747...183,100,008
Ensembl chr 2:183,078,559...183,100,008
JBrowse link
G DUSP3 dual specificity phosphatase 3 IMP
IBA
IDA
(PMID:19010898)
(PMID:21873635)
(PMID:11085983)
UniProtKB
GO_Central
PMID:11085983, PMID:19010898, PMID:21873635 NCBI chr17:43,766,125...43,778,977
Ensembl chr17:43,766,125...43,778,977
JBrowse link
G F2RL1 F2R like trypsin receptor 1 IDA (PMID:19781631) UniProtKB PMID:19781631 NCBI chr 5:76,819,030...76,835,315
Ensembl chr 5:76,818,933...76,835,315
JBrowse link
G FKTN fukutin IMP (PMID:18808525) BHF-UCL PMID:18808525 NCBI chr 9:105,558,117...105,655,950
Ensembl chr 9:105,558,122...105,653,820
Ensembl chr 9:105,558,122...105,653,820
JBrowse link
G GPS2 G protein pathway suppressor 2 IDA (PMID:11931768) UniProtKB PMID:11931768 NCBI chr17:7,312,661...7,315,360
Ensembl chr17:7,311,324...7,315,564
JBrowse link
G HDAC3 histone deacetylase 3 IMP (PMID:11931768) UniProtKB PMID:11931768 NCBI chr 5:141,620,881...141,636,849
Ensembl chr 5:141,620,876...141,636,849
JBrowse link
G ITCH itchy E3 ubiquitin protein ligase ISS BHF-UCL GO_REF:0000024 NCBI chr20:34,363,273...34,511,773
Ensembl chr20:34,363,241...34,540,748
JBrowse link
G KLHL31 kelch like family member 31 IMP (PMID:18719355) UniProt PMID:18719355 NCBI chr 6:53,647,916...53,665,854
Ensembl chr 6:53,647,916...53,665,756
JBrowse link
G MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 ISO RGD PMID:12064607 RGD:1299562 NCBI chr11:45,885,651...45,906,465
Ensembl chr11:45,885,651...45,906,465
JBrowse link
G MARVELD3 MARVEL domain containing 3 IMP (PMID:24567356) MGI PMID:24567356 NCBI chr16:71,626,180...71,641,965
Ensembl chr16:71,626,161...71,642,114
JBrowse link
G MECOM MDS1 and EVI1 complex locus IMP (PMID:10856240) UniProtKB PMID:10856240 NCBI chr 3:169,083,506...169,663,781
Ensembl chr 3:169,083,499...169,663,775
JBrowse link
G MEN1 menin 1 IDA (PMID:12226747) UniProtKB PMID:12226747 NCBI chr11:64,803,514...64,811,294
Ensembl chr11:64,803,510...64,811,294
JBrowse link
G NCOR1 nuclear receptor corepressor 1 IDA (PMID:11931768) UniProtKB PMID:11931768 NCBI chr17:16,029,157...16,216,475
Ensembl chr17:16,029,157...16,218,185
JBrowse link
G PAFAH1B1 platelet activating factor acetylhydrolase 1b regulatory subunit 1 IEA Ensembl GO_REF:0000107 NCBI chr17:2,593,210...2,685,617
Ensembl chr17:2,593,210...2,685,615
JBrowse link
G PER1 period circadian regulator 1 ISS UniProtKB GO_REF:0000024 NCBI chr17:8,140,470...8,156,360
Ensembl chr17:8,140,472...8,156,506
JBrowse link
G PINK1 PTEN induced kinase 1 TAS (PMID:18221368) ParkinsonsUK-UCL PMID:18221368 NCBI chr 1:20,633,458...20,651,511
Ensembl chr 1:20,633,458...20,651,511
JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase ISS ParkinsonsUK-UCL GO_REF:0000024 NCBI chr 6:161,347,417...162,727,802
Ensembl chr 6:161,347,417...162,727,771
Ensembl chr 6:161,347,417...162,727,771
JBrowse link
G SFRP4 secreted frizzled related protein 4 ISO RGD PMID:18567805 RGD:4107045 NCBI chr 7:37,905,932...37,916,817
Ensembl chr 7:37,905,932...38,025,695
JBrowse link
G SH3RF2 SH3 domain containing ring finger 2 ISS UniProtKB GO_REF:0000024 NCBI chr 5:145,936,570...146,081,773
Ensembl chr 5:145,936,578...146,081,791
JBrowse link
G SIRPA signal regulatory protein alpha ISS ARUK-UCL GO_REF:0000024 NCBI chr20:1,894,167...1,940,592
Ensembl chr20:1,894,167...1,940,592
JBrowse link
G TAOK3 TAO kinase 3 IDA (PMID:10559204) HGNC PMID:10559204 NCBI chr12:118,149,801...118,372,950
Ensembl chr12:118,149,801...118,372,907
JBrowse link
G ZMYND11 zinc finger MYND-type containing 11 IMP (PMID:20732415) UniProtKB PMID:20732415 NCBI chr10:130,088...254,637
Ensembl chr10:134,465...254,637
JBrowse link
G ZNF675 zinc finger protein 675 IDA (PMID:11751921) UniProtKB PMID:11751921 NCBI chr19:23,652,801...23,687,212
Ensembl chr19:23,525,631...23,687,220
JBrowse link
negative regulation of JUN kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AIDA axin interactor, dorsalization associated IDA (PMID:17681137) MGI PMID:17681137 NCBI chr 1:222,668,013...222,712,895
Ensembl chr 1:222,668,013...222,713,210
JBrowse link
G DNAJA1 DnaJ heat shock protein family (Hsp40) member A1 IMP (PMID:24512202) UniProtKB PMID:24512202 NCBI chr 9:33,025,273...33,039,907
Ensembl chr 9:33,025,273...33,039,907
JBrowse link
G DUSP10 dual specificity phosphatase 10 IDA
IBA
(PMID:10391943)
(PMID:21873635)
BHF-UCL
GO_Central
PMID:10391943, PMID:21873635 NCBI chr 1:221,701,424...221,742,091
Ensembl chr 1:221,701,424...221,742,089
JBrowse link
G DUSP19 dual specificity phosphatase 19 ISS BHF-UCL GO_REF:0000024 NCBI chr 2:183,078,747...183,100,008
Ensembl chr 2:183,078,559...183,100,008
JBrowse link
G GSTP1 glutathione S-transferase pi 1 IDA (PMID:16636664) BHF-UCL PMID:16636664 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G HIPK3 homeodomain interacting protein kinase 3 ISS UniProtKB GO_REF:0000024 NCBI chr11:33,256,672...33,357,023
Ensembl chr11:33,256,672...33,357,023
JBrowse link
G MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 ISS UniProtKB GO_REF:0000024 NCBI chr11:45,885,651...45,906,465
Ensembl chr11:45,885,651...45,906,465
JBrowse link
G NPPA natriuretic peptide A IDA (PMID:22399583) UniProt PMID:22399583 NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345
JBrowse link
G PDCD4 programmed cell death 4 ISS UniProtKB GO_REF:0000024 NCBI chr10:110,871,928...110,900,006
Ensembl chr10:110,871,795...110,900,006
JBrowse link
G PTPN22 protein tyrosine phosphatase non-receptor type 22 IMP (PMID:23991106) UniProtKB PMID:23991106 NCBI chr 1:113,813,811...113,871,761
Ensembl chr 1:113,813,811...113,871,753
JBrowse link
G SERPINB3 serpin family B member 3 IMP (PMID:21383048) UniProtKB PMID:21383048 NCBI chr18:63,655,197...63,661,893
Ensembl chr18:63,655,197...63,661,893
JBrowse link
G SFRP1 secreted frizzled related protein 1 IEA Ensembl GO_REF:0000107 NCBI chr 8:41,261,962...41,309,473
Ensembl chr 8:41,261,962...41,309,473
JBrowse link
G SFRP2 secreted frizzled related protein 2 IEA Ensembl GO_REF:0000107 NCBI chr 4:153,780,591...153,789,083
Ensembl chr 4:153,780,591...153,789,083
JBrowse link
G SFRP5 secreted frizzled related protein 5 ISO (MGI:MGI:3839161|PMID:19300477) MGI PMID:19300477 MGI:MGI:3839161 NCBI chr10:97,766,751...97,771,999
Ensembl chr10:97,766,751...97,771,999
JBrowse link
G TP73 tumor protein p73 ISO (MGI:MGI:3574697|PMID:15483136) MGI PMID:15483136 MGI:MGI:3574697 NCBI chr 1:3,652,516...3,736,201
Ensembl chr 1:3,652,516...3,736,201
JBrowse link
G ZNF675 zinc finger protein 675 IDA (PMID:11751921) BHF-UCL PMID:11751921 NCBI chr19:23,652,801...23,687,212
Ensembl chr19:23,525,631...23,687,220
JBrowse link
negative regulation of p38MAPK cascade term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYLD CYLD lysine 63 deubiquitinase IDA (PMID:29291351) UniProtKB PMID:29291351 NCBI chr16:50,742,086...50,801,935
Ensembl chr16:50,742,050...50,801,935
JBrowse link
G DLG1 discs large MAGUK scaffold protein 1 IMP (PMID:20551903) UniProtKB PMID:20551903 NCBI chr 3:197,042,560...197,299,321
Ensembl chr 3:197,042,560...197,299,330
JBrowse link
G DUSP1 dual specificity phosphatase 1 IMP
IBA
(PMID:22991462)
(PMID:21873635)
BHF-UCL
GO_Central
PMID:21873635, PMID:22991462 NCBI chr 5:172,768,096...172,771,195
Ensembl chr 5:172,768,096...172,771,195
JBrowse link
G DUSP10 dual specificity phosphatase 10 NAS
IDA
(PMID:23993976)
(PMID:10391943)
BHF-UCL PMID:10391943, PMID:23993976 NCBI chr 1:221,701,424...221,742,091
Ensembl chr 1:221,701,424...221,742,089
JBrowse link
G EZR ezrin IMP (PMID:20551903) UniProtKB PMID:20551903 NCBI chr 6:158,765,744...158,819,368
Ensembl chr 6:158,765,741...158,819,368
JBrowse link
G HSPH1 heat shock protein family H (Hsp110) member 1 ISO (MGI:MGI:3822965|PMID:18681888) MGI PMID:18681888 MGI:MGI:3822965 NCBI chr13:31,134,973...31,162,388
Ensembl chr13:31,134,973...31,162,388
JBrowse link
G PTPN22 protein tyrosine phosphatase non-receptor type 22 IEA
IBA
IMP
(PMID:21873635)
(PMID:23991106)
Ensembl
GO_Central
UniProtKB
PMID:21873635, PMID:23991106 GO_REF:0000107 NCBI chr 1:113,813,811...113,871,761
Ensembl chr 1:113,813,811...113,871,753
JBrowse link
negative regulation of stress-activated MAPK cascade term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DUSP10 dual specificity phosphatase 10 ISO (MGI:MGI:4366202|PMID:19696743) MGI PMID:19696743 MGI:MGI:4366202 NCBI chr 1:221,701,424...221,742,091
Ensembl chr 1:221,701,424...221,742,089
JBrowse link
G FOXM1 forkhead box M1 IMP (PMID:19696738) BHF-UCL PMID:19696738 NCBI chr12:2,857,680...2,877,174
Ensembl chr12:2,857,681...2,877,155
Ensembl chr12:2,857,681...2,877,155
JBrowse link
G FOXO1 forkhead box O1 IDA (PMID:19696738) BHF-UCL PMID:19696738 NCBI chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641
JBrowse link
G GSTP1 glutathione S-transferase pi 1 ISS BHF-UCL GO_REF:0000024 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G IGBP1 immunoglobulin binding protein 1 IMP (PMID:17438131) UniProtKB PMID:17438131 NCBI chr  X:70,133,447...70,166,324
Ensembl chr  X:70,133,447...70,166,324
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor ISS UniProtKB GO_REF:0000024 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
JBrowse link
G PBK PDZ binding kinase IEA Ensembl GO_REF:0000107 NCBI chr 8:27,809,624...27,837,817
Ensembl chr 8:27,809,624...27,838,082
JBrowse link
G PPIA peptidylprolyl isomerase A IMP (PMID:26095851) UniProt PMID:26095851 NCBI chr 7:44,795,960...44,803,117
Ensembl chr 7:44,796,680...44,824,564
JBrowse link
G QARS1 glutaminyl-tRNA synthetase 1 IDA (PMID:11096076) CAFA PMID:11096076 NCBI chr 3:49,095,932...49,104,758
Ensembl chr 3:49,095,932...49,105,130
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18650
    response to stimulus 10129
      response to stress 4574
        cellular response to stress 2294
          stress-activated protein kinase signaling cascade 329
            negative regulation of stress-activated protein kinase signaling cascade 52
              negative regulation of stress-activated MAPK cascade + 52
Path 2
Term Annotations click to browse term
  biological_process 18650
    biological regulation 13283
      regulation of biological process 12625
        regulation of cellular process 12020
          signal transduction 6562
            intracellular signal transduction 2978
              stress-activated protein kinase signaling cascade 329
                regulation of stress-activated protein kinase signaling cascade 263
                  negative regulation of stress-activated protein kinase signaling cascade 52
                    negative regulation of stress-activated MAPK cascade + 52
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.