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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of stress-activated protein kinase signaling cascade
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Accession:GO:0070303 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade.
Synonyms:exact_synonym: down regulation of stress-activated protein kinase signaling pathway;   downregulation of stress-activated protein kinase signaling pathway;   negative regulation of SAPK signaling pathway;   negative regulation of stress-activated protein kinase signaling pathway;   negative regulation of stress-activated protein kinase signalling pathway
 narrow_synonym: inhibition of stress-activated protein kinase signaling pathway


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negative regulation of JNK cascade term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aida axin interactor, dorsalization associated ISO
IPI
IMP
(MGI:MGI:3799599|PMID:17681137) MGI
UniProtKB
PMID:17681137 MGI:MGI:3799599 NCBI chr 1:183,297,060...183,324,501
Ensembl chr 1:183,296,590...183,325,476
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 ISO RGD GO_REF:0000096, MGI:MGI:4417868 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Cdc42se1 CDC42 small effector 1 ISS (MGI:MGI:1861241|PMID:10910960) MGI PMID:10910960 MGI:MGI:1861241 NCBI chr 3:95,228,424...95,236,424
Ensembl chr 3:95,228,732...95,236,409
JBrowse link
G Ceacam1 carcinoembryonic antigen-related cell adhesion molecule 1 IMP (MGI:MGI:3693042|PMID:17081782) MGI PMID:17081782 MGI:MGI:3693042 NCBI chr 7:25,461,702...25,477,647
Ensembl chr 7:25,461,707...25,477,603
JBrowse link
G Cyld CYLD lysine 63 deubiquitinase ISO
IDA
(MGI:MGI:6162308|PMID:29291351) MGI
UniProtKB
PMID:29291351 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:6162308 NCBI chr 8:88,696,878...88,751,946
Ensembl chr 8:88,697,028...88,751,945
JBrowse link
G Dact1 dishevelled-binding antagonist of beta-catenin 1 IDA
IBA
ISO
(MGI:MGI:5437437|PMID:17197390)
(MGI:MGI:6201960|PMID:21873635)
UniProtKB
GO_Central
MGI
PMID:17197390, PMID:21873635 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:5437437, MGI:MGI:6201960 NCBI chr12:71,309,884...71,320,107
Ensembl chr12:71,309,884...71,320,107
JBrowse link
G Dusp10 dual specificity phosphatase 10 IMP
IBA
ISO
(MGI:MGI:3051749|PMID:15306813)
(MGI:MGI:6201960|PMID:21873635)
MGI
GO_Central
PMID:15306813, PMID:21873635 GO_REF:0000096, MGI:MGI:3051749, MGI:MGI:4834177, MGI:MGI:6201960 NCBI chr 1:184,034,381...184,075,636
Ensembl chr 1:184,013,302...184,075,636
JBrowse link
G Dusp19 dual specificity phosphatase 19 IDA (MGI:MGI:2182169|PMID:11959862) BHF-UCL PMID:11959862 MGI:MGI:2182169 NCBI chr 2:80,617,214...80,631,661
Ensembl chr 2:80,617,045...80,632,361
JBrowse link
G Dusp3 dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) ISO
IBA
(MGI:MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:6201960 NCBI chr11:101,971,141...101,987,013
Ensembl chr11:101,971,143...101,987,013
JBrowse link
G F2rl1 coagulation factor II (thrombin) receptor-like 1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr13:95,511,718...95,525,240
Ensembl chr13:95,511,732...95,525,227
JBrowse link
G Fktn fukutin ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 4:53,714,107...53,765,785
Ensembl chr 4:53,713,998...53,777,890
JBrowse link
G Gps2 G protein pathway suppressor 2 ISO
IMP
(MGI:MGI:6148454|PMID:22424771) MGI
UniProtKB
PMID:22424771 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:6148454 NCBI chr11:69,913,980...69,917,056
Ensembl chr11:69,913,888...69,916,591
JBrowse link
G Hdac3 histone deacetylase 3 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr18:37,936,971...37,955,015
Ensembl chr18:37,935,844...37,955,016
JBrowse link
G Itch itchy, E3 ubiquitin protein ligase IMP (MGI:MGI:3774677|PMID:18246070) BHF-UCL PMID:18246070 MGI:MGI:3774677 NCBI chr 2:155,133,481...155,226,855
Ensembl chr 2:155,133,509...155,226,855
JBrowse link
G Klhl31 kelch-like 31 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 9:77,636,732...77,660,125
Ensembl chr 9:77,636,500...77,660,127
JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 ISO RGD GO_REF:0000096, MGI:MGI:4417868 NCBI chr 2:92,383,671...92,401,346
Ensembl chr 2:92,383,676...92,401,263
JBrowse link
G Marveld3 MARVEL (membrane-associating) domain containing 3 ISO MGI GO_REF:0000008, MGI:MGI:2154458 NCBI chr 8:109,947,909...109,962,205
Ensembl chr 8:109,947,914...109,962,203
JBrowse link
G Mecom MDS1 and EVI1 complex locus ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 3:29,951,296...30,509,759
Ensembl chr 3:29,951,296...30,548,008
JBrowse link
G Men1 multiple endocrine neoplasia 1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr19:6,334,979...6,340,894
Ensembl chr19:6,334,979...6,340,891
JBrowse link
G Ncor1 nuclear receptor co-repressor 1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr11:62,315,663...62,457,414
Ensembl chr11:62,316,426...62,458,541
JBrowse link
G Pafah1b1 platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 IGI (MGI:MGI:5308511|PMID:22073305) MGI PMID:22073305 MGI:MGI:5308511 NCBI chr11:74,673,949...74,724,384
Ensembl chr11:74,673,949...74,724,670
JBrowse link
G Per1 period circadian clock 1 ISO RGD GO_REF:0000096, MGI:MGI:4417868 NCBI chr11:69,095,108...69,109,965
Ensembl chr11:69,095,217...69,109,960
JBrowse link
G Sfrp4 secreted frizzled-related protein 4 ISO RGD GO_REF:0000096, MGI:MGI:4417868 NCBI chr13:19,623,175...19,632,825
Ensembl chr13:19,623,104...19,632,994
JBrowse link
G Sh3rf2 SH3 domain containing ring finger 2 ISO MGI GO_REF:0000096, MGI:MGI:4417868 NCBI chr18:42,052,502...42,158,695
Ensembl chr18:42,053,667...42,158,960
JBrowse link
G Sirpa signal-regulatory protein alpha IMP (MGI:MGI:3760575|PMID:17954568) ARUK-UCL PMID:17954568 MGI:MGI:3760575 NCBI chr 2:129,591,042...129,632,228
Ensembl chr 2:129,592,835...129,632,228
JBrowse link
G Taok3 TAO kinase 3 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 5:117,120,111...117,275,101
Ensembl chr 5:117,120,129...117,275,219
JBrowse link
G Zmynd11 zinc finger, MYND domain containing 11 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr13:9,684,836...9,766,014
Ensembl chr13:9,684,833...9,765,330
JBrowse link
negative regulation of JUN kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aida axin interactor, dorsalization associated ISO
IMP
IDA
(MGI:MGI:3799599|PMID:17681137) MGI PMID:17681137 MGI:MGI:3799599 NCBI chr 1:183,297,060...183,324,501
Ensembl chr 1:183,296,590...183,325,476
JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 4:40,722,468...40,734,965
Ensembl chr 4:40,722,150...40,737,149
JBrowse link
G Dusp10 dual specificity phosphatase 10 IMP
IBA
ISO
(MGI:MGI:3051749|PMID:15306813)
(MGI:MGI:6201960|PMID:21873635)
MGI
GO_Central
PMID:15306813, PMID:21873635 GO_REF:0000096, MGI:MGI:3051749, MGI:MGI:4834177, MGI:MGI:6201960 NCBI chr 1:184,034,381...184,075,636
Ensembl chr 1:184,013,302...184,075,636
JBrowse link
G Dusp19 dual specificity phosphatase 19 IDA (MGI:MGI:2182169|PMID:11959862) BHF-UCL PMID:11959862 MGI:MGI:2182169 NCBI chr 2:80,617,214...80,631,661
Ensembl chr 2:80,617,045...80,632,361
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 IMP
IDA
(MGI:MGI:3721484|PMID:12646564)
(MGI:MGI:5009198|PMID:10945608), (MGI:MGI:5009411|PMID:16023107)
BHF-UCL PMID:10945608, PMID:12646564, PMID:16023107 MGI:MGI:3721484, MGI:MGI:5009198, MGI:MGI:5009411 NCBI chr19:4,035,411...4,037,912
Ensembl chr19:4,035,407...4,037,985
JBrowse link
G Hipk3 homeodomain interacting protein kinase 3 IMP (MGI:MGI:1913166|PMID:11034606) UniProtKB PMID:11034606 MGI:MGI:1913166 NCBI chr 2:104,426,481...104,494,489
Ensembl chr 2:104,426,481...104,494,446
JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 ISO RGD GO_REF:0000096, MGI:MGI:4417868 NCBI chr 2:92,383,671...92,401,346
Ensembl chr 2:92,383,676...92,401,263
JBrowse link
G Nppa natriuretic peptide type A ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 4:148,000,722...148,002,074
Ensembl chr 4:148,000,722...148,002,079
JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 3:103,856,575...103,912,252
Ensembl chr 3:103,859,795...103,912,247
JBrowse link
G Serpinb3d serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3D ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 1:107,078,163...107,083,480
Ensembl chr 1:107,078,167...107,083,506
JBrowse link
G Sfrp1 secreted frizzled-related protein 1 IGI (MGI:MGI:3839161|PMID:19300477) MGI PMID:19300477 MGI:MGI:3839161 NCBI chr 8:23,411,383...23,449,632
Ensembl chr 8:23,411,502...23,449,632
JBrowse link
G Sfrp2 secreted frizzled-related protein 2 IGI (MGI:MGI:3839161|PMID:19300477) MGI PMID:19300477 MGI:MGI:3839161 NCBI chr 3:83,765,750...83,774,314
Ensembl chr 3:83,766,321...83,774,316
JBrowse link
G Sfrp5 secreted frizzled-related sequence protein 5 IGI (MGI:MGI:3839161|PMID:19300477) MGI PMID:19300477 MGI:MGI:3839161 NCBI chr19:42,197,971...42,202,252
Ensembl chr19:42,197,971...42,202,252
JBrowse link
G Trp73 transformation related protein 73 IDA (MGI:MGI:3574697|PMID:15483136) MGI PMID:15483136 MGI:MGI:3574697 NCBI chr 4:154,056,249...154,139,875
Ensembl chr 4:154,056,253...154,140,208
Ensembl chr 4:154,056,253...154,140,208
JBrowse link
negative regulation of p38MAPK cascade term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyld CYLD lysine 63 deubiquitinase ISO
IDA
(MGI:MGI:6162308|PMID:29291351) MGI
UniProtKB
PMID:29291351 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:6162308 NCBI chr 8:88,696,878...88,751,946
Ensembl chr 8:88,697,028...88,751,945
JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr16:31,663,443...31,873,356
Ensembl chr16:31,663,443...31,875,129
JBrowse link
G Dusp1 dual specificity phosphatase 1 ISO
IBA
(MGI:MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:6201960 NCBI chr17:26,505,591...26,508,472
Ensembl chr17:26,505,590...26,562,128
JBrowse link
G Dusp10 dual specificity phosphatase 10 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 1:184,034,381...184,075,636
Ensembl chr 1:184,013,302...184,075,636
JBrowse link
G Ezr ezrin ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr17:6,738,131...6,782,780
Ensembl chr17:6,738,041...6,782,784
JBrowse link
G Hsph1 heat shock 105kDa/110kDa protein 1 IGI (MGI:MGI:3822965|PMID:18681888) MGI PMID:18681888 MGI:MGI:3822965 NCBI chr 5:149,616,843...149,636,498
Ensembl chr 5:149,614,287...149,636,376
JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) IMP
ISO
IBA
(MGI:MGI:5640942|PMID:23991106)
(MGI:MGI:6201960|PMID:21873635)
UniProtKB
MGI
GO_Central
PMID:21873635, PMID:23991106 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:5640942, MGI:MGI:6201960 NCBI chr 3:103,856,575...103,912,252
Ensembl chr 3:103,859,795...103,912,247
JBrowse link
negative regulation of stress-activated MAPK cascade term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dusp10 dual specificity phosphatase 10 IMP (MGI:MGI:4366202|PMID:19696743) MGI PMID:19696743 MGI:MGI:4366202 NCBI chr 1:184,034,381...184,075,636
Ensembl chr 1:184,013,302...184,075,636
JBrowse link
G Foxm1 forkhead box M1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 6:128,362,994...128,375,886
Ensembl chr 6:128,362,967...128,376,146
JBrowse link
G Foxo1 forkhead box O1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 3:52,268,337...52,350,109
Ensembl chr 3:52,268,336...52,353,221
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 IDA (MGI:MGI:5009411|PMID:16023107) BHF-UCL PMID:16023107 MGI:MGI:5009411 NCBI chr19:4,035,411...4,037,912
Ensembl chr19:4,035,407...4,037,985
JBrowse link
G Igbp1 immunoglobulin (CD79A) binding protein 1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr  X:100,494,291...100,516,125
Ensembl chr  X:100,494,291...100,516,125
JBrowse link
G Myc myelocytomatosis oncogene ISO (PMID:19545562) UniProtKB PMID:19545562 NCBI chr15:61,985,341...61,990,361
Ensembl chr15:61,985,391...61,990,374
JBrowse link
G Pbk PDZ binding kinase IMP (MGI:MGI:5293269|PMID:21715333) MGI PMID:21715333 MGI:MGI:5293269 NCBI chr14:65,805,911...65,817,822
Ensembl chr14:65,805,837...65,817,822
JBrowse link
G Ppia peptidylprolyl isomerase A ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr11:6,415,867...6,419,817
Ensembl chr11:6,415,443...6,419,817
JBrowse link
G Qars glutaminyl-tRNA synthetase ISO (PMID:11096076) CAFA PMID:11096076 NCBI chr 9:108,508,005...108,515,941
Ensembl chr 9:108,507,706...108,515,941
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 23360
    response to stimulus 10279
      response to stress 4150
        cellular response to stress 1974
          stress-activated protein kinase signaling cascade 287
            negative regulation of stress-activated protein kinase signaling cascade 48
              negative regulation of stress-activated MAPK cascade + 48
Path 2
Term Annotations click to browse term
  biological_process 23360
    biological regulation 13063
      regulation of biological process 12439
        regulation of cellular process 11886
          signal transduction 6319
            intracellular signal transduction 2561
              stress-activated protein kinase signaling cascade 287
                regulation of stress-activated protein kinase signaling cascade 249
                  negative regulation of stress-activated protein kinase signaling cascade 48
                    negative regulation of stress-activated MAPK cascade + 48
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.