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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of stress-activated protein kinase signaling cascade
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Accession:GO:0070303 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade.
Synonyms:exact_synonym: down regulation of stress-activated protein kinase signaling pathway;   downregulation of stress-activated protein kinase signaling pathway;   negative regulation of SAPK signaling pathway;   negative regulation of stress-activated protein kinase signaling pathway;   negative regulation of stress-activated protein kinase signalling pathway
 narrow_synonym: inhibition of stress-activated protein kinase signaling pathway


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negative regulation of JNK cascade term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AIDA axin interactor, dorsalization associated ISO (MGI:MGI:3799599|PMID:17681137) UniProtKB PMID:17681137 MGI:MGI:3799599 NCBI chr10:11,430,758...11,466,849
Ensembl chr10:11,428,396...11,466,645
JBrowse link
G AKT1 AKT serine/threonine kinase 1 ISO RGD PMID:17064355 RGD:2298577
G CEACAM1 CEA cell adhesion molecule 1 ISO (MGI:MGI:3693042|PMID:17081782) MGI PMID:17081782 MGI:MGI:3693042 NCBI chr 6:49,437,308...49,460,614 JBrowse link
G CYLD CYLD lysine 63 deubiquitinase IEA Ensembl GO_REF:0000107 NCBI chr 6:34,058,091...34,121,939
Ensembl chr 6:34,059,941...34,121,272
JBrowse link
G DACT1 dishevelled binding antagonist of beta catenin 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:187,719,391...187,729,568
Ensembl chr 1:187,719,162...187,729,925
JBrowse link
G DUSP10 dual specificity phosphatase 10 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr10:10,866,446...10,905,852
Ensembl chr10:10,866,448...10,905,857
JBrowse link
G DUSP19 dual specificity phosphatase 19 ISO (MGI:MGI:2182169|PMID:11959862) BHF-UCL PMID:11959862 MGI:MGI:2182169 NCBI chr15:88,549,250...88,574,978
Ensembl chr15:88,549,275...88,574,243
JBrowse link
G DUSP3 dual specificity phosphatase 3 IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr12:19,336,308...19,349,739
Ensembl chr12:19,336,354...19,349,734
JBrowse link
G F2RL1 F2R like trypsin receptor 1 IEA Ensembl GO_REF:0000107 NCBI chr 2:85,732,082...85,747,552
Ensembl chr 2:85,732,189...85,750,858
JBrowse link
G FKTN fukutin ISO (PMID:18808525) BHF-UCL PMID:18808525 NCBI chr 1:246,852,387...246,916,650 JBrowse link
G GPS2 G protein pathway suppressor 2 IEA Ensembl GO_REF:0000107 NCBI chr12:52,664,869...52,667,643
Ensembl chr12:52,664,873...52,667,610
JBrowse link
G HDAC3 histone deacetylase 3 IEA Ensembl GO_REF:0000107 NCBI chr 2:143,273,188...143,287,421
Ensembl chr 2:143,273,191...143,287,387
JBrowse link
G ITCH itchy E3 ubiquitin protein ligase IEA Ensembl GO_REF:0000107 NCBI chr17:37,810,113...37,918,963
Ensembl chr17:37,810,183...37,918,208
JBrowse link
G KLHL31 kelch like family member 31 IEA Ensembl GO_REF:0000107 NCBI chr 7:27,088,393...27,106,104
Ensembl chr 7:27,062,044...27,106,111
JBrowse link
G MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 ISO RGD PMID:12064607 RGD:1299562 NCBI chr 2:16,562,687...16,584,763
Ensembl chr 2:16,564,255...16,584,768
JBrowse link
G MARVELD3 MARVEL domain containing 3 IEA Ensembl GO_REF:0000107 NCBI chr 6:14,616,508...14,630,798
Ensembl chr 6:14,616,481...14,630,794
JBrowse link
G MECOM MDS1 and EVI1 complex locus IEA Ensembl GO_REF:0000107 NCBI chr13:107,753,207...108,336,136
Ensembl chr13:107,754,480...108,335,503
JBrowse link
G MEN1 menin 1 IEA Ensembl GO_REF:0000107 NCBI chr 2:7,358,130...7,364,952
Ensembl chr 2:7,357,951...7,365,128
JBrowse link
G NCOR1 nuclear receptor corepressor 1 ISO (PMID:11931768) UniProtKB PMID:11931768 NCBI chr12:59,256,868...59,392,564 JBrowse link
G PAFAH1B1 platelet activating factor acetylhydrolase 1b regulatory subunit 1 IEA Ensembl GO_REF:0000107 NCBI chr12:48,567,329...48,735,836
Ensembl chr12:48,567,337...48,735,838
JBrowse link
G PER1 period circadian regulator 1 ISO PMID:24447840 UniProt PMID:24447840 RGD:8655527 NCBI chr12:53,361,863...53,376,723
Ensembl chr12:53,361,868...53,376,611
JBrowse link
G SFRP4 secreted frizzled related protein 4 ISO RGD PMID:18567805 RGD:4107045 NCBI chr 9:108,404,314...108,414,335
Ensembl chr 9:108,404,042...108,414,311
JBrowse link
G SH3RF2 SH3 domain containing ring finger 2 ISO PMID:22128169 UniProt PMID:22128169 RGD:13673844 NCBI chr 2:147,290,322...147,413,151
Ensembl chr 2:147,290,579...147,413,148
JBrowse link
G SIRPA signal regulatory protein alpha ISO (MGI:MGI:3760575|PMID:17954568) ARUK-UCL PMID:17954568 MGI:MGI:3760575 NCBI chr17:33,566,270...33,611,375 JBrowse link
G TAOK3 TAO kinase 3 IEA Ensembl GO_REF:0000107 NCBI chr14:34,322,016...34,514,234
Ensembl chr14:34,409,070...34,513,025
JBrowse link
G ZMYND11 zinc finger MYND-type containing 11 IEA Ensembl GO_REF:0000107 NCBI chr10:69,159,456...69,295,640
Ensembl chr10:69,159,455...69,295,307
JBrowse link
negative regulation of JUN kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AIDA axin interactor, dorsalization associated IEA Ensembl GO_REF:0000107 NCBI chr10:11,430,758...11,466,849
Ensembl chr10:11,428,396...11,466,645
JBrowse link
G DNAJA1 DnaJ heat shock protein family (Hsp40) member A1 IEA Ensembl GO_REF:0000107 NCBI chr10:33,432,529...33,445,556
Ensembl chr10:33,432,844...33,445,532
JBrowse link
G DUSP10 dual specificity phosphatase 10 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr10:10,866,446...10,905,852
Ensembl chr10:10,866,448...10,905,857
JBrowse link
G DUSP19 dual specificity phosphatase 19 ISO (MGI:MGI:2182169|PMID:11959862) BHF-UCL PMID:11959862 MGI:MGI:2182169 NCBI chr15:88,549,250...88,574,978
Ensembl chr15:88,549,275...88,574,243
JBrowse link
G HIPK3 homeodomain interacting protein kinase 3 IEA Ensembl GO_REF:0000107 NCBI chr 2:27,580,125...27,685,926
Ensembl chr 2:27,580,129...27,685,846
JBrowse link
G LOC100739163 glutathione S-transferase P-like ISO (MGI:MGI:5009198|PMID:10945608), (MGI:MGI:5009411|PMID:16023107)
(MGI:MGI:3721484|PMID:12646564)
(PMID:16636664)
BHF-UCL PMID:10945608, PMID:12646564, PMID:16023107, PMID:16636664 MGI:MGI:3721484, MGI:MGI:5009198, MGI:MGI:5009411 NCBI chr 2:4,978,761...4,982,233 JBrowse link
G MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 ISO PMID:21076496 RGD
UniProt
PMID:12064607, PMID:21076496 RGD:1299562, RGD:13673827 NCBI chr 2:16,562,687...16,584,763
Ensembl chr 2:16,564,255...16,584,768
JBrowse link
G NPPA natriuretic peptide A IEA Ensembl GO_REF:0000107 NCBI chr 6:71,919,557...71,921,345
Ensembl chr 6:71,919,495...71,932,254
JBrowse link
G PTPN22 protein tyrosine phosphatase non-receptor type 22 ISO (PMID:23991106) UniProtKB PMID:23991106 NCBI chr 4:106,692,102...106,758,101
Ensembl chr 4:106,686,604...106,758,099
JBrowse link
G SFRP1 secreted frizzled related protein 1 IEA Ensembl GO_REF:0000107 NCBI chr17:10,436,414...10,489,773
Ensembl chr17:10,436,426...10,489,748
JBrowse link
G SFRP2 secreted frizzled related protein 2 IEA Ensembl GO_REF:0000107 NCBI chr 8:75,337,311...75,345,926
Ensembl chr 8:75,337,133...75,345,926
JBrowse link
G SFRP5 secreted frizzled related protein 5 ISO (MGI:MGI:3839161|PMID:19300477) MGI PMID:19300477 MGI:MGI:3839161 NCBI chr14:109,120,382...109,125,655
Ensembl chr14:109,119,822...109,125,686
JBrowse link
G TP73 tumor protein p73 ISO (MGI:MGI:3574697|PMID:15483136) MGI PMID:15483136 MGI:MGI:3574697 NCBI chr 6:65,169,770...65,228,997
Ensembl chr 6:65,177,682...65,228,992
JBrowse link
negative regulation of p38MAPK cascade term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYLD CYLD lysine 63 deubiquitinase IEA Ensembl GO_REF:0000107 NCBI chr 6:34,058,091...34,121,939
Ensembl chr 6:34,059,941...34,121,272
JBrowse link
G DLG1 discs large MAGUK scaffold protein 1 IEA Ensembl GO_REF:0000107 NCBI chr13:132,819,931...133,084,880
Ensembl chr13:132,820,870...133,086,843
JBrowse link
G DUSP1 dual specificity phosphatase 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr16:51,457,924...51,461,095
Ensembl chr16:51,458,020...51,461,086
JBrowse link
G DUSP10 dual specificity phosphatase 10 IEA Ensembl GO_REF:0000107 NCBI chr10:10,866,446...10,905,852
Ensembl chr10:10,866,448...10,905,857
JBrowse link
G EZR ezrin IEA Ensembl GO_REF:0000107 NCBI chr 1:8,403,362...8,452,750
Ensembl chr 1:8,403,453...8,452,750
JBrowse link
G HSPH1 heat shock protein family H (Hsp110) member 1 ISO (MGI:MGI:3822965|PMID:18681888) MGI PMID:18681888 MGI:MGI:3822965 NCBI chr11:7,733,874...7,759,528
Ensembl chr11:7,733,874...7,759,576
JBrowse link
G PTPN22 protein tyrosine phosphatase non-receptor type 22 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 4:106,692,102...106,758,101
Ensembl chr 4:106,686,604...106,758,099
JBrowse link
negative regulation of stress-activated MAPK cascade term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DUSP10 dual specificity phosphatase 10 ISO (MGI:MGI:4366202|PMID:19696743) MGI PMID:19696743 MGI:MGI:4366202 NCBI chr10:10,866,446...10,905,852
Ensembl chr10:10,866,448...10,905,857
JBrowse link
G FOXM1 forkhead box M1 IEA Ensembl GO_REF:0000107 NCBI chr 5:67,246,219...67,263,215
Ensembl chr 5:67,245,694...67,263,211
Ensembl chr 5:67,245,694...67,263,211
JBrowse link
G FOXO1 forkhead box O1 IEA Ensembl GO_REF:0000107 NCBI chr11:15,317,222...15,410,059
Ensembl chr11:15,317,124...15,410,473
JBrowse link
G IGBP1 immunoglobulin binding protein 1 ISO (PMID:17438131) UniProtKB PMID:17438131 NCBI chr  X:56,173,773...56,206,121 JBrowse link
G LOC100739163 glutathione S-transferase P-like ISO (MGI:MGI:5009411|PMID:16023107) BHF-UCL PMID:16023107 MGI:MGI:5009411 NCBI chr 2:4,978,761...4,982,233 JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor ISS UniProt GO_REF:0000024 NCBI chr 4:12,455,141...12,460,360
Ensembl chr 4:12,455,119...12,461,078
JBrowse link
G PBK PDZ binding kinase IEA Ensembl GO_REF:0000107 NCBI chr14:11,543,657...11,577,286
Ensembl chr14:11,543,599...11,566,702
JBrowse link
G PPIA peptidylprolyl isomerase A ISO (PMID:26095851) UniProt PMID:26095851 NCBI chr18:50,563,130...50,566,857 JBrowse link
G QARS1 glutaminyl-tRNA synthetase 1 IEA Ensembl GO_REF:0000107 NCBI chr13:31,715,686...31,723,200
Ensembl chr13:31,715,687...31,723,197
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16524
    response to stimulus 8966
      response to stress 3628
        cellular response to stress 1897
          stress-activated protein kinase signaling cascade 275
            negative regulation of stress-activated protein kinase signaling cascade 46
              negative regulation of stress-activated MAPK cascade + 46
Path 2
Term Annotations click to browse term
  biological_process 16524
    biological regulation 11994
      regulation of biological process 11420
        regulation of cellular process 10970
          signal transduction 5920
            intracellular signal transduction 2481
              stress-activated protein kinase signaling cascade 275
                regulation of stress-activated protein kinase signaling cascade 240
                  negative regulation of stress-activated protein kinase signaling cascade 46
                    negative regulation of stress-activated MAPK cascade + 46
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.