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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of stress-activated protein kinase signaling cascade
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Accession:GO:0070303 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade.
Synonyms:exact_synonym: down regulation of stress-activated protein kinase signaling pathway;   downregulation of stress-activated protein kinase signaling pathway;   negative regulation of SAPK signaling pathway;   negative regulation of stress-activated protein kinase signaling pathway;   negative regulation of stress-activated protein kinase signalling pathway
 narrow_synonym: inhibition of stress-activated protein kinase signaling pathway


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negative regulation of JNK cascade term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aida axin interactor, dorsalization associated ISO UniProtKB:O35625 (MGI:MGI:3799599|PMID:17681137) RGD PMID:17681137 MGI:MGI:3799599 NCBI chr13:101,698,096...101,724,928
Ensembl chr13:101,698,096...101,724,923
JBrowse link
G Akt1 AKT serine/threonine kinase 1 IDA RGD PMID:17064355 RGD:2298577 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 ISO (MGI:MGI:3693042|PMID:17081782) RGD PMID:17081782 MGI:MGI:3693042 NCBI chr 1:82,327,955...82,344,345
Ensembl chr 1:82,327,955...82,344,345
JBrowse link
G Cyld CYLD lysine 63 deubiquitinase ISS
ISO
IEA
GO_REF:0000024
(MGI:MGI:6162308|PMID:29291351)
(PMID:29291351)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:29291351 GO_REF:0000024, GO_REF:0000107, MGI:MGI:6162308 NCBI chr19:19,264,984...19,323,817
Ensembl chr19:19,265,164...19,315,357
JBrowse link
G Dact1 dishevelled-binding antagonist of beta-catenin 1 ISO
IBA
(PMID:17197390)
PMID:21873635
(MGI:MGI:5437437|PMID:17197390)
RGD PMID:17197390, PMID:21873635 MGI:MGI:5437437, RGD:13792537 NCBI chr 6:93,740,440...93,751,003
Ensembl chr 6:93,740,586...93,749,809
JBrowse link
G Dusp10 dual specificity phosphatase 10 ISO
IBA
MGI:MGI:3052343 (MGI:MGI:3051749|PMID:15306813)
PMID:21873635
(PMID:10391943)
RGD PMID:10391943, PMID:15306813, PMID:21873635 MGI:MGI:3051749, RGD:13792537 NCBI chr13:104,284,660...104,321,455
Ensembl chr13:104,284,660...104,321,455
JBrowse link
G Dusp19 dual specificity phosphatase 19 ISO (MGI:MGI:2182169|PMID:11959862) RGD PMID:11959862 MGI:MGI:2182169 NCBI chr 3:67,849,966...67,862,475
Ensembl chr 3:67,849,966...67,862,475
JBrowse link
G Dusp3 dual specificity phosphatase 3 ISO
IBA
(PMID:11085983), (PMID:19010898)
PMID:21873635
RGD PMID:11085983, PMID:19010898, PMID:21873635 RGD:13792537 NCBI chr10:89,904,578...89,918,296
Ensembl chr10:89,904,560...89,918,427
JBrowse link
G F2rl1 F2R like trypsin receptor 1 ISO (PMID:19781631) RGD PMID:19781631 NCBI chr 2:25,222,324...25,235,275
Ensembl chr 2:25,222,328...25,235,275
JBrowse link
G Fktn fukutin ISO (PMID:18808525) RGD PMID:18808525 NCBI chr 5:70,522,001...70,578,270
Ensembl chr 5:70,528,688...70,578,273
JBrowse link
G Gps2 G protein pathway suppressor 2 ISO (PMID:11931768)
(MGI:MGI:6148454|PMID:22424771)
RGD PMID:11931768, PMID:22424771 MGI:MGI:6148454 NCBI chr10:56,524,327...56,527,447
Ensembl chr10:56,524,468...56,526,987
JBrowse link
G Hdac3 histone deacetylase 3 IEA
ISO
GO_REF:0000107
(PMID:11931768)
Ensembl
RGD
PMID:11931768 GO_REF:0000107 NCBI chr18:31,073,057...31,094,347
Ensembl chr18:31,073,058...31,094,303
JBrowse link
G Itch itchy E3 ubiquitin protein ligase ISO (MGI:MGI:3774677|PMID:18246070) RGD PMID:18246070 MGI:MGI:3774677 NCBI chr 3:150,660,665...150,752,016
Ensembl chr 3:150,686,638...150,749,827
JBrowse link
G Klhl31 kelch-like family member 31 ISO (PMID:18719355) RGD PMID:18719355 NCBI chr 8:84,945,444...84,968,811
Ensembl chr 8:84,945,444...84,968,811
JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 IMP RGD PMID:12064607 RGD:1299562 NCBI chr 3:81,295,023...81,304,181
Ensembl chr 3:81,295,024...81,304,181
JBrowse link
G Marveld3 MARVEL domain containing 3 ISO (PMID:24567356) RGD PMID:24567356 NCBI chr19:41,710,076...41,724,923
Ensembl chr19:41,710,102...41,724,923
JBrowse link
G Mecom MDS1 and EVI1 complex locus ISO (PMID:10856240) RGD PMID:10856240 NCBI chr 2:117,396,084...117,993,604
Ensembl chr 2:117,396,007...117,454,769
JBrowse link
G Men1 menin 1 ISO (PMID:12226747) RGD PMID:12226747 NCBI chr 1:221,704,394...221,710,343
Ensembl chr 1:221,704,493...221,710,331
JBrowse link
G Ncor1 nuclear receptor co-repressor 1 IEA
ISO
GO_REF:0000107
(PMID:11931768)
Ensembl
RGD
PMID:11931768 GO_REF:0000107 NCBI chr10:48,629,121...48,772,890
Ensembl chr10:48,629,121...48,772,890
JBrowse link
G Pafah1b1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 ISO MGI:MGI:1100089 (MGI:MGI:5308511|PMID:22073305) RGD PMID:22073305 MGI:MGI:5308511 NCBI chr10:61,456,144...61,577,412
Ensembl chr10:61,456,145...61,577,412
JBrowse link
G Per1 period circadian regulator 1 IMP PMID:24447840 UniProt PMID:24447840 RGD:8655527 NCBI chr10:55,681,761...55,696,557
Ensembl chr10:55,687,050...55,695,994
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISS GO_REF:0000024 ParkinsonsUK-UCL GO_REF:0000024 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Sfrp4 secreted frizzled-related protein 4 IDA RGD PMID:18567805 RGD:4107045 NCBI chr17:47,383,983...47,394,065
Ensembl chr17:47,297,489...47,394,328
JBrowse link
G Sh3rf2 SH3 domain containing ring finger 2 IMP PMID:22128169 UniProt PMID:22128169 RGD:13673844 NCBI chr18:36,371,041...36,471,020
Ensembl chr18:36,371,041...36,471,015
JBrowse link
G Sirpa signal-regulatory protein alpha ISO
IEA
(MGI:MGI:3760575|PMID:17954568)
GO_REF:0000107
RGD
Ensembl
PMID:17954568 GO_REF:0000107, MGI:MGI:3760575 NCBI chr 3:122,113,735...122,152,478
Ensembl chr 3:122,114,108...122,152,477
JBrowse link
G Taok3 TAO kinase 3 ISO
IEA
(PMID:10559204)
GO_REF:0000107
RGD
Ensembl
PMID:10559204 GO_REF:0000107 NCBI chr12:45,037,951...45,116,593
Ensembl chr12:45,037,883...45,182,974
JBrowse link
G Zmynd11 zinc finger, MYND-type containing 11 ISO (PMID:20732415) RGD PMID:20732415 NCBI chr17:63,825,616...63,914,740
Ensembl chr17:63,825,627...63,879,171
JBrowse link
negative regulation of JUN kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aida axin interactor, dorsalization associated ISO (MGI:MGI:3799599|PMID:17681137)
(PMID:17681137)
RGD PMID:17681137 MGI:MGI:3799599 NCBI chr13:101,698,096...101,724,928
Ensembl chr13:101,698,096...101,724,923
JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 ISO
ISS
(PMID:24512202)
GO_REF:0000024
RGD
UniProt
PMID:24512202 GO_REF:0000024 NCBI chr 5:57,028,467...57,039,378
Ensembl chr 5:57,028,467...57,039,378
JBrowse link
G Dusp10 dual specificity phosphatase 10 ISO
IBA
MGI:MGI:3052343 (MGI:MGI:3051749|PMID:15306813)
PMID:21873635
(PMID:10391943)
RGD PMID:10391943, PMID:15306813, PMID:21873635 MGI:MGI:3051749, RGD:13792537 NCBI chr13:104,284,660...104,321,455
Ensembl chr13:104,284,660...104,321,455
JBrowse link
G Dusp19 dual specificity phosphatase 19 ISO (MGI:MGI:2182169|PMID:11959862) RGD PMID:11959862 MGI:MGI:2182169 NCBI chr 3:67,849,966...67,862,475
Ensembl chr 3:67,849,966...67,862,475
JBrowse link
G Gstp1 glutathione S-transferase pi 1 ISO
ISS
(PMID:16636664)
(MGI:MGI:3721484|PMID:12646564), (MGI:MGI:5009198|PMID:10945608), (MGI:MGI:5009411|PMID:16023107)
GO_REF:0000024
RGD
BHF-UCL
PMID:10945608, PMID:12646564, PMID:16023107, PMID:16636664 GO_REF:0000024, MGI:MGI:3721484, MGI:MGI:5009198, MGI:MGI:5009411 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hipk3 homeodomain interacting protein kinase 3 IEA
ISO
GO_REF:0000107
(MGI:MGI:1913166|PMID:11034606)
Ensembl
RGD
PMID:11034606 GO_REF:0000107, MGI:MGI:1913166 NCBI chr 3:94,349,778...94,419,185
Ensembl chr 3:94,352,969...94,419,048
JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 IMP PMID:21076496 RGD
UniProt
PMID:12064607, PMID:21076496 RGD:1299562, RGD:13673827 NCBI chr 3:81,295,023...81,304,181
Ensembl chr 3:81,295,024...81,304,181
JBrowse link
G Nppa natriuretic peptide A ISO (PMID:22399583) RGD PMID:22399583 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Pdcd4 programmed cell death 4 ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 1:274,616,625...274,648,204
Ensembl chr 1:274,625,224...274,648,204
JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 ISO (PMID:23991106) RGD PMID:23991106 NCBI chr 2:206,342,066...206,390,348
Ensembl chr 2:206,342,066...206,390,348
JBrowse link
G Serpinb3 serpin family B member 3 ISO (PMID:21383048) RGD PMID:21383048 NCBI chr13:27,186,701...27,193,211
Ensembl chr13:27,187,130...27,192,592
JBrowse link
G Sfrp1 secreted frizzled-related protein 1 ISO
IEA
MGI:MGI:108078|MGI:MGI:1860298 (MGI:MGI:3839161|PMID:19300477)
GO_REF:0000107
RGD
Ensembl
PMID:19300477 GO_REF:0000107, MGI:MGI:3839161 NCBI chr16:73,372,007...73,410,777
Ensembl chr16:73,372,007...73,410,777
JBrowse link
G Sfrp2 secreted frizzled-related protein 2 ISO MGI:MGI:1860298|MGI:MGI:892014 (MGI:MGI:3839161|PMID:19300477) RGD PMID:19300477 MGI:MGI:3839161 NCBI chr 2:182,723,732...182,731,277
Ensembl chr 2:182,723,854...182,731,764
JBrowse link
G Sfrp5 secreted frizzled-related protein 5 ISO MGI:MGI:108078|MGI:MGI:892014 (MGI:MGI:3839161|PMID:19300477) RGD PMID:19300477 MGI:MGI:3839161 NCBI chr 1:261,442,108...261,446,570
Ensembl chr 1:261,442,108...261,446,570
JBrowse link
G Tp73 tumor protein p73 ISO (MGI:MGI:3574697|PMID:15483136) RGD PMID:15483136 MGI:MGI:3574697 NCBI chr 5:171,355,876...171,415,354
Ensembl chr 5:171,355,876...171,415,354
JBrowse link
negative regulation of p38MAPK cascade term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyld CYLD lysine 63 deubiquitinase ISS
ISO
IEA
GO_REF:0000024
(MGI:MGI:6162308|PMID:29291351)
(PMID:29291351)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:29291351 GO_REF:0000024, GO_REF:0000107, MGI:MGI:6162308 NCBI chr19:19,264,984...19,323,817
Ensembl chr19:19,265,164...19,315,357
JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 IEA
ISO
GO_REF:0000107
(PMID:20551903)
Ensembl
RGD
PMID:20551903 GO_REF:0000107 NCBI chr11:72,164,566...72,378,895
Ensembl chr11:72,163,749...72,378,895
JBrowse link
G Dusp1 dual specificity phosphatase 1 ISO
IBA
(PMID:22991462)
PMID:21873635
RGD PMID:22991462, PMID:21873635 RGD:13792537 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
JBrowse link
G Dusp10 dual specificity phosphatase 10 ISO (PMID:10391943) RGD PMID:10391943 NCBI chr13:104,284,660...104,321,455
Ensembl chr13:104,284,660...104,321,455
JBrowse link
G Ezr ezrin ISO (PMID:20551903) RGD PMID:20551903 NCBI chr 1:47,287,872...47,331,412
Ensembl chr 1:47,287,874...47,331,412
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 ISO MGI:MGI:1346865 (MGI:MGI:3822965|PMID:18681888) RGD PMID:18681888 MGI:MGI:3822965 NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902
JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 ISO
IBA
(PMID:23991106)
PMID:21873635
(MGI:MGI:5640942|PMID:23991106)
RGD PMID:23991106, PMID:21873635 MGI:MGI:5640942, RGD:13792537 NCBI chr 2:206,342,066...206,390,348
Ensembl chr 2:206,342,066...206,390,348
JBrowse link
negative regulation of stress-activated MAPK cascade term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dusp10 dual specificity phosphatase 10 ISO MGI:MGI:3052343 (MGI:MGI:4366202|PMID:19696743) RGD PMID:19696743 MGI:MGI:4366202 NCBI chr13:104,284,660...104,321,455
Ensembl chr13:104,284,660...104,321,455
JBrowse link
G Foxm1 forkhead box M1 ISO
IEA
(PMID:19696738)
GO_REF:0000107
RGD
Ensembl
PMID:19696738 GO_REF:0000107 NCBI chr 4:161,685,236...161,697,633
Ensembl chr 4:161,685,258...161,696,305
JBrowse link
G Foxo1 forkhead box O1 ISO (PMID:19696738) RGD PMID:19696738 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Gstp1 glutathione S-transferase pi 1 ISO
ISS
(MGI:MGI:5009411|PMID:16023107)
GO_REF:0000024
RGD
BHF-UCL
PMID:16023107 GO_REF:0000024, MGI:MGI:5009411 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Igbp1 immunoglobulin binding protein 1 ISO (PMID:17438131) RGD PMID:17438131 NCBI chr  X:70,322,764...70,345,005
Ensembl chr  X:70,322,755...70,345,005
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor ISO (PMID:19545562) RGD PMID:19545562 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Pbk PDZ binding kinase ISO MGI:MGI:5293435 (MGI:MGI:5293269|PMID:21715333) RGD PMID:21715333 MGI:MGI:5293269 NCBI chr15:42,489,253...42,500,377
Ensembl chr15:42,489,377...42,500,395
JBrowse link
G Ppia peptidylprolyl isomerase A ISO
ISS
(PMID:26095851)
GO_REF:0000024
RGD
UniProt
PMID:26095851 GO_REF:0000024 NCBI chr14:86,673,775...86,677,443
Ensembl chr14:86,673,775...86,677,443
JBrowse link
G Ppial4d peptidylprolyl isomerase A (cyclophilin A)-like 4D ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr14:22,706,906...22,707,648
Ensembl chr14:22,706,901...22,707,668
JBrowse link
G Qars1 glutaminyl-tRNA synthetase 1 ISO (PMID:11096076) RGD PMID:11096076 NCBI chr 8:117,297,670...117,305,708
Ensembl chr 8:117,297,670...117,305,702
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    response to stimulus 10568
      response to stress 4059
        cellular response to stress 1992
          stress-activated protein kinase signaling cascade 287
            negative regulation of stress-activated protein kinase signaling cascade 50
              negative regulation of stress-activated MAPK cascade + 50
Path 2
Term Annotations click to browse term
  biological_process 20014
    biological regulation 13759
      regulation of biological process 13071
        regulation of cellular process 12560
          signal transduction 7015
            intracellular signal transduction 2615
              stress-activated protein kinase signaling cascade 287
                regulation of stress-activated protein kinase signaling cascade 249
                  negative regulation of stress-activated protein kinase signaling cascade 50
                    negative regulation of stress-activated MAPK cascade + 50
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.