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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of stress-activated protein kinase signaling cascade
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Accession:GO:0070303 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade.
Synonyms:exact_synonym: down regulation of stress-activated protein kinase signaling pathway;   downregulation of stress-activated protein kinase signaling pathway;   negative regulation of SAPK signaling pathway;   negative regulation of stress-activated protein kinase signaling pathway;   negative regulation of stress-activated protein kinase signalling pathway
 narrow_synonym: inhibition of stress-activated protein kinase signaling pathway


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negative regulation of JNK cascade term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 ISO RGD PMID:17064355 RGD:2298577 NCBI chrNW_004936621:620,163...639,115 JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 ISO (MGI:MGI:3693042|PMID:17081782) MGI PMID:17081782 MGI:MGI:3693042 NCBI chrNW_004936706:37,480...53,306 JBrowse link
G Cyld CYLD lysine 63 deubiquitinase ISO (PMID:29291351)
(MGI:MGI:6162308|PMID:29291351)
UniProtKB PMID:29291351 MGI:MGI:6162308 NCBI chrNW_004936475:3,750,917...3,812,118 JBrowse link
G Dact1 dishevelled binding antagonist of beta catenin 1 ISO (PMID:17197390)
(MGI:MGI:5437437|PMID:17197390)
UniProtKB PMID:17197390 MGI:MGI:5437437 NCBI chrNW_004936495:3,017,029...3,026,759 JBrowse link
G Dusp10 dual specificity phosphatase 10 ISO (PMID:10391943)
(MGI:MGI:3051749|PMID:15306813)
BHF-UCL
MGI
PMID:10391943, PMID:15306813 MGI:MGI:3051749 NCBI chrNW_004936650:679,650...718,867 JBrowse link
G Dusp19 dual specificity phosphatase 19 ISO (MGI:MGI:2182169|PMID:11959862) BHF-UCL PMID:11959862 MGI:MGI:2182169 NCBI chrNW_004936509:11,653,282...11,670,425 JBrowse link
G Dusp3 dual specificity phosphatase 3 ISO (PMID:19010898)
(PMID:11085983)
UniProtKB PMID:11085983, PMID:19010898 NCBI chrNW_004936541:325,443...338,426 JBrowse link
G F2rl1 F2R like trypsin receptor 1 ISO (PMID:19781631) UniProtKB PMID:19781631 NCBI chrNW_004936549:142,281...153,575 JBrowse link
G Fktn fukutin ISO (PMID:18808525) BHF-UCL PMID:18808525 NCBI chrNW_004936559:6,612,318...6,680,690 JBrowse link
G Gps2 G protein pathway suppressor 2 ISO (MGI:MGI:6148454|PMID:22424771)
(PMID:11931768)
UniProtKB PMID:11931768, PMID:22424771 MGI:MGI:6148454 NCBI chrNW_004936595:608,730...611,871 JBrowse link
G Hdac3 histone deacetylase 3 ISO (PMID:11931768) UniProtKB PMID:11931768 NCBI chrNW_004936504:12,530,546...12,546,556 JBrowse link
G Itch itchy E3 ubiquitin protein ligase ISO (MGI:MGI:3774677|PMID:18246070) BHF-UCL PMID:18246070 MGI:MGI:3774677 NCBI chrNW_004936561:6,140,236...6,265,734 JBrowse link
G Klhl31 kelch like family member 31 ISO (PMID:18719355) UniProt PMID:18719355 NCBI chrNW_004936476:7,269,396...7,287,617 JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 ISO RGD PMID:12064607 RGD:1299562 NCBI chrNW_004936562:3,113,217...3,122,794 JBrowse link
G Marveld3 MARVEL domain containing 3 ISO (PMID:24567356) MGI PMID:24567356 NCBI chrNW_004936475:22,141,276...22,156,649 JBrowse link
G Mecom MDS1 and EVI1 complex locus ISO (PMID:10856240) UniProtKB PMID:10856240 NCBI chrNW_004936593:2,742,236...3,282,596 JBrowse link
G Men1 menin 1 ISO (PMID:12226747) UniProtKB PMID:12226747 NCBI chrNW_004936599:4,504,489...4,510,085 JBrowse link
G Ncor1 nuclear receptor corepressor 1 ISO (PMID:11931768) UniProtKB PMID:11931768 NCBI chrNW_004936821:382,756...538,254 JBrowse link
G Pafah1b1 platelet activating factor acetylhydrolase 1b regulatory subunit 1 ISO (MGI:MGI:5308511|PMID:22073305) MGI PMID:22073305 MGI:MGI:5308511 NCBI chrNW_004936538:8,612,142...8,693,698 JBrowse link
G Per1 period circadian regulator 1 ISO PMID:24447840 UniProt PMID:24447840 RGD:8655527 NCBI chrNW_004936595:1,366,883...1,382,138 JBrowse link
G Sfrp4 secreted frizzled related protein 4 ISO RGD PMID:18567805 RGD:4107045 NCBI chrNW_004936478:13,257,183...13,266,972 JBrowse link
G Sh3rf2 SH3 domain containing ring finger 2 ISO PMID:22128169 UniProt PMID:22128169 RGD:13673844 NCBI chrNW_004936504:8,602,116...8,731,099 JBrowse link
G Sirpa signal regulatory protein alpha ISO (MGI:MGI:3760575|PMID:17954568) ARUK-UCL PMID:17954568 MGI:MGI:3760575 NCBI chrNW_004936485:16,608,317...16,654,552 JBrowse link
G Taok3 TAO kinase 3 ISO (PMID:10559204) HGNC PMID:10559204 NCBI chrNW_004936668:2,116,804...2,305,331 JBrowse link
G Zmynd11 zinc finger MYND-type containing 11 ISO (PMID:20732415) UniProtKB PMID:20732415 NCBI chrNW_004936484:13,779,266...13,872,042 JBrowse link
negative regulation of JUN kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 ISO (PMID:24512202) UniProtKB PMID:24512202 NCBI chrNW_004936524:1,599,883...1,611,302 JBrowse link
G Dusp10 dual specificity phosphatase 10 ISO (PMID:10391943)
(MGI:MGI:3051749|PMID:15306813)
BHF-UCL
MGI
PMID:10391943, PMID:15306813 MGI:MGI:3051749 NCBI chrNW_004936650:679,650...718,867 JBrowse link
G Dusp19 dual specificity phosphatase 19 ISO (MGI:MGI:2182169|PMID:11959862) BHF-UCL PMID:11959862 MGI:MGI:2182169 NCBI chrNW_004936509:11,653,282...11,670,425 JBrowse link
G Gstp1 glutathione S-transferase pi 1 ISO (PMID:16636664)
(MGI:MGI:5009198|PMID:10945608), (MGI:MGI:5009411|PMID:16023107)
(MGI:MGI:3721484|PMID:12646564)
BHF-UCL PMID:10945608, PMID:12646564, PMID:16023107, PMID:16636664 MGI:MGI:3721484, MGI:MGI:5009198, MGI:MGI:5009411 NCBI chrNW_004936599:2,197,681...2,200,642 JBrowse link
G Hipk3 homeodomain interacting protein kinase 3 ISO (MGI:MGI:1913166|PMID:11034606) UniProtKB PMID:11034606 MGI:MGI:1913166 NCBI chrNW_004936533:4,570,600...4,662,296 JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 ISO PMID:21076496 UniProt
RGD
PMID:12064607, PMID:21076496 RGD:1299562, RGD:13673827 NCBI chrNW_004936562:3,113,217...3,122,794 JBrowse link
G Nppa natriuretic peptide A ISO (PMID:22399583) UniProt PMID:22399583 NCBI chrNW_004936474:671,362...673,610 JBrowse link
G Ptpn22 protein tyrosine phosphatase non-receptor type 22 ISO (PMID:23991106) UniProtKB PMID:23991106 NCBI chrNW_004936690:2,180,804...2,232,869 JBrowse link
G Sfrp1 secreted frizzled related protein 1 ISO (MGI:MGI:3839161|PMID:19300477) MGI PMID:19300477 MGI:MGI:3839161 NCBI chrNW_004936785:1,276,478...1,320,397 JBrowse link
G Sfrp2 secreted frizzled related protein 2 ISO (MGI:MGI:3839161|PMID:19300477) MGI PMID:19300477 MGI:MGI:3839161 NCBI chrNW_004936576:604,174...612,440 JBrowse link
G Sfrp5 secreted frizzled related protein 5 ISO (MGI:MGI:3839161|PMID:19300477) MGI PMID:19300477 MGI:MGI:3839161 NCBI chrNW_004936636:1,968,410...1,973,885 JBrowse link
G Tp73 tumor protein p73 ISO (MGI:MGI:3574697|PMID:15483136) MGI PMID:15483136 MGI:MGI:3574697 NCBI chrNW_004936737:171,894...211,464 JBrowse link
negative regulation of p38MAPK cascade term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyld CYLD lysine 63 deubiquitinase ISO (MGI:MGI:6162308|PMID:29291351)
(PMID:29291351)
UniProtKB PMID:29291351 MGI:MGI:6162308 NCBI chrNW_004936475:3,750,917...3,812,118 JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 ISO (PMID:20551903) UniProtKB PMID:20551903 NCBI chrNW_004936833:551,989...843,064 JBrowse link
G Dusp1 dual specificity phosphatase 1 ISO (PMID:22991462) BHF-UCL PMID:22991462 NCBI chrNW_004936609:2,688,170...2,691,057 JBrowse link
G Dusp10 dual specificity phosphatase 10 ISO (PMID:10391943) BHF-UCL PMID:10391943 NCBI chrNW_004936650:679,650...718,867 JBrowse link
G Ezr ezrin ISO (PMID:20551903) UniProtKB PMID:20551903 NCBI chrNW_004936489:10,413,374...10,457,771 JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 ISO (MGI:MGI:3822965|PMID:18681888) MGI PMID:18681888 MGI:MGI:3822965 NCBI chrNW_004936472:25,855,873...25,879,062 JBrowse link
G Ptpn22 protein tyrosine phosphatase non-receptor type 22 ISO (PMID:23991106)
(MGI:MGI:5640942|PMID:23991106)
UniProtKB PMID:23991106 MGI:MGI:5640942 NCBI chrNW_004936690:2,180,804...2,232,869 JBrowse link
negative regulation of stress-activated MAPK cascade term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dusp10 dual specificity phosphatase 10 ISO (MGI:MGI:4366202|PMID:19696743) MGI PMID:19696743 MGI:MGI:4366202 NCBI chrNW_004936650:679,650...718,867 JBrowse link
G Foxm1 forkhead box M1 ISO (PMID:19696738) BHF-UCL PMID:19696738 NCBI chrNW_004936606:3,185,289...3,198,427 JBrowse link
G Foxo1 forkhead box O1 ISO (PMID:19696738) BHF-UCL PMID:19696738 NCBI chrNW_004936565:5,210,014...5,299,213 JBrowse link
G Gstp1 glutathione S-transferase pi 1 ISO (MGI:MGI:5009411|PMID:16023107) BHF-UCL PMID:16023107 MGI:MGI:5009411 NCBI chrNW_004936599:2,197,681...2,200,642 JBrowse link
G Igbp1 immunoglobulin binding protein 1 ISO (PMID:17438131) UniProtKB PMID:17438131 NCBI chrNW_004936762:1,292,572...1,319,145 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor ISO (PMID:19545562) UniProtKB PMID:19545562 NCBI chrNW_004936470:20,480,844...20,485,955 JBrowse link
G Pbk PDZ binding kinase ISO (MGI:MGI:5293269|PMID:21715333) MGI PMID:21715333 MGI:MGI:5293269 NCBI chrNW_004936675:704,001...722,769 JBrowse link
G Ppia peptidylprolyl isomerase A ISO (PMID:26095851) UniProt PMID:26095851 NCBI chrNW_004936478:19,669,727...19,673,355 JBrowse link
G Qars1 glutaminyl-tRNA synthetase 1 ISO (PMID:11096076) CAFA PMID:11096076 NCBI chrNW_004936529:802,753...810,270 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11968
    response to stimulus 6404
      response to stress 3056
        cellular response to stress 1660
          stress-activated protein kinase signaling cascade 256
            negative regulation of stress-activated protein kinase signaling cascade 45
              negative regulation of stress-activated MAPK cascade + 45
Path 2
Term Annotations click to browse term
  biological_process 11968
    biological regulation 8764
      regulation of biological process 8316
        regulation of cellular process 7896
          signal transduction 3695
            intracellular signal transduction 1982
              stress-activated protein kinase signaling cascade 256
                regulation of stress-activated protein kinase signaling cascade 225
                  negative regulation of stress-activated protein kinase signaling cascade 45
                    negative regulation of stress-activated MAPK cascade + 45
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.