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ONTOLOGY REPORT - ANNOTATIONS


Term:lens fiber cell differentiation
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Accession:GO:0070306 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires specialized features of a lens fiber cell, any of the elongated, tightly packed cells that make up the bulk of the mature lens in the camera-type eye. The cytoplasm of a lens fiber cell is devoid of most intracellular organelles including the cell nucleus, and contains primarily crystallins, a group of water-soluble proteins expressed in vary large quantities.
Synonyms:exact_synonym: lens fibre cell differentiation


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lens fiber cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Crygd crystallin, gamma D JBrowse link 9 71,776,568 71,778,323 RGD:1601018
RGD:1624291
G Fzr1 fizzy and cell division cycle 20 related 1 JBrowse link 7 11,201,690 11,213,614 RGD:1624291
RGD:1600115
G Kdm5b lysine demethylase 5B JBrowse link 13 51,384,371 51,455,392 RGD:9587771
G Maf MAF bZIP transcription factor JBrowse link 19 48,179,826 48,200,995 RGD:1600115
RGD:13792537
RGD:1624291
G Nf2 neurofibromin 2 JBrowse link 14 84,996,905 85,088,547 RGD:1600115
RGD:1624291
G Ntrk3 neurotrophic receptor tyrosine kinase 3 JBrowse link 1 139,890,537 140,262,503 RGD:1624291
RGD:1600115
G Pitx3 paired-like homeodomain 3 JBrowse link 1 265,886,766 265,899,947 RGD:1624291
RGD:1600115
G Six3 SIX homeobox 3 JBrowse link 6 8,886,730 8,891,094 RGD:1624291
RGD:1600115
G Skil SKI-like proto-oncogene JBrowse link 2 115,862,932 115,891,304 RGD:1624291
RGD:1600115
G Slc7a11 solute carrier family 7 member 11 JBrowse link 2 139,453,774 139,528,479 RGD:2315033
G Smad3 SMAD family member 3 JBrowse link 8 68,569,530 68,678,349 RGD:1624291
RGD:1600115
G Tdrd7 tudor domain containing 7 JBrowse link 5 61,557,909 61,631,719 RGD:1624291
RGD:1600115
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:1624291
RGD:1600115
lens fiber cell development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bfsp1 beaded filament structural protein 1 JBrowse link 3 137,935,345 137,992,652 RGD:1624291
RGD:13792537
RGD:1600115
G Bfsp2 beaded filament structural protein 2 JBrowse link 8 111,908,614 111,965,889 RGD:1624291
RGD:1600115
G Crygb crystallin, gamma B JBrowse link 9 71,796,204 71,798,265 RGD:1624291
G Fgfr2 fibroblast growth factor receptor 2 JBrowse link 1 200,590,951 200,696,946 RGD:1624291
G Fgfr3 fibroblast growth factor receptor 3 JBrowse link 14 82,272,322 82,287,739 RGD:1624291
G Frs2 fibroblast growth factor receptor substrate 2 JBrowse link 7 60,128,506 60,210,482 RGD:1624291
RGD:1600115
G Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 JBrowse link 8 22,648,323 22,739,468 RGD:1624291
G Tmod1 tropomodulin 1 JBrowse link 5 61,635,244 61,712,052 RGD:1624291
RGD:1600115
G Vim vimentin JBrowse link 17 80,882,715 80,891,200 RGD:1624291
RGD:1600115
lens fiber cell morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abi2 abl-interactor 2 JBrowse link 9 67,234,612 67,284,504 RGD:1624291
G Cryaa crystallin, alpha A JBrowse link 20 10,438,444 10,442,189 RGD:1624291
RGD:1600115
G Crygb crystallin, gamma B JBrowse link 9 71,796,204 71,798,265 RGD:1624291
G Epha2 Eph receptor A2 JBrowse link 5 159,845,773 159,874,203 RGD:1624291
RGD:1600115
G Prox1 prospero homeobox 1 JBrowse link 13 108,382,536 108,444,107 RGD:1624291
RGD:13792537
G Prox2 prospero homeobox 2 JBrowse link 6 108,911,705 108,920,767 RGD:13792537
G Tbc1d20 TBC1 domain family, member 20 JBrowse link 3 147,772,006 147,790,946 RGD:1624291
RGD:1600115
negative regulation of lens fiber cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Foxe3 forkhead box E3 JBrowse link 5 133,724,796 133,725,656 RGD:10047273
RGD:1624291
positive regulation of lens fiber cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Zeb2 zinc finger E-box binding homeobox 2 JBrowse link 3 29,857,289 29,985,932 RGD:1624291
RGD:1600115
regulation of lens fiber cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdkn1b cyclin-dependent kinase inhibitor 1B JBrowse link 4 168,689,043 168,694,159 RGD:1624291
RGD:1600115
G Cdkn1c cyclin-dependent kinase inhibitor 1C JBrowse link 1 216,661,067 216,663,791 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18166
    developmental process 6539
      anatomical structure development 6020
        lens development in camera-type eye 85
          lens fiber cell differentiation 32
            lens fiber cell development + 15
            lens fiber cell fate commitment 0
            negative regulation of lens fiber cell differentiation 1
            positive regulation of lens fiber cell differentiation 1
            regulation of lens fiber cell differentiation + 4
Path 2
Term Annotations click to browse term
  biological_process 18166
    developmental process 6539
      anatomical structure development 6020
        multicellular organism development 5501
          system development 5050
            sensory system development 439
              visual system development 435
                eye development 431
                  camera-type eye development 386
                    lens development in camera-type eye 85
                      lens fiber cell differentiation 32
                        lens fiber cell development + 15
                        lens fiber cell fate commitment 0
                        negative regulation of lens fiber cell differentiation 1
                        positive regulation of lens fiber cell differentiation 1
                        regulation of lens fiber cell differentiation + 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.