Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:hepatocyte differentiation
go back to main search page
Accession:GO:0070365 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires the specialized features of a hepatocyte. A hepatocyte is specialized epithelial cell that is organized into interconnected plates called lobules, and is the main structural component of the liver.
Synonyms:exact_synonym: liver cell differentiation


show annotations for term's descendants           Sort by:
 
hepatocyte differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 IEP
IBA
PMID:21873635 RGD
GO_Central
PMID:11668598, PMID:21873635 RGD:2306909, RGD:13792537 NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012
JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 IEP RGD PMID:12939595 RGD:4144098 NCBI chr 9:74,113,437...74,236,274
Ensembl chr 9:74,124,016...74,236,274
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 IEP RGD PMID:17574236 RGD:2306655 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G E2f7 E2F transcription factor 7 ISO
ISS
(MGI:MGI:5449497|PMID:23064266)
GO_REF:0000024
RGD
UniProt
PMID:23064266 GO_REF:0000024, MGI:MGI:5449497 NCBI chr 7:53,275,659...53,318,261
Ensembl chr 7:53,275,676...53,316,481
JBrowse link
G E2f8 E2F transcription factor 8 IEA
ISO
ISS
GO_REF:0000107
(MGI:MGI:5449497|PMID:23064266), (MGI:MGI:5449498|PMID:23064264)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:23064264, PMID:23064266 GO_REF:0000024, GO_REF:0000107, MGI:MGI:5449497, MGI:MGI:5449498 NCBI chr 1:104,185,436...104,203,683
Ensembl chr 1:104,187,100...104,202,591
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 IEP RGD PMID:10934156 RGD:14701049 NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068
JBrowse link
G Hhex hematopoietically expressed homeobox ISO MGI:MGI:2448661 (MGI:MGI:1891782|PMID:11027604) RGD PMID:11027604 MGI:MGI:1891782 NCBI chr 1:256,101,994...256,107,581
Ensembl chr 1:256,101,903...256,107,649
JBrowse link
G Hnf1b HNF1 homeobox B IEP RGD PMID:18286537 RGD:2312718 NCBI chr10:71,159,863...71,218,902
Ensembl chr10:71,159,869...71,218,902
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha IEP
IEA
GO_REF:0000002 InterPro PMID:19621519 GO_REF:0000002, RGD:12904750 NCBI chr 3:159,902,441...159,965,003
Ensembl chr 3:159,902,441...159,965,003
JBrowse link
G Itga2 integrin subunit alpha 2 IEP RGD PMID:16458388 RGD:2307397 NCBI chr 2:46,996,904...47,097,011
Ensembl chr 2:47,000,323...47,096,961
JBrowse link
G Krt18 keratin 18 IEP RGD PMID:24340101, PMID:28941653 RGD:27226712, RGD:27226713 NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871
JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:34,216,735...34,224,357
Ensembl chr15:34,216,833...34,224,193
JBrowse link
G Prox1 prospero homeobox 1 ISO (PMID:15232737) RGD PMID:15232737 NCBI chr13:108,382,536...108,444,107
Ensembl chr13:108,382,399...108,443,294
JBrowse link
G Taf10 TATA-box binding protein associated factor 10 ISO MGI:MGI:2176946|MGI:MGI:3606185 (MGI:MGI:3806427|PMID:18722179) RGD PMID:18722179 MGI:MGI:3806427 NCBI chr 1:170,585,160...170,586,428
Ensembl chr 1:170,585,167...170,586,603
JBrowse link
G Wnt1 Wnt family member 1 IMP RGD PMID:20413689 RGD:2326223 NCBI chr 7:140,464,999...140,469,046
Ensembl chr 7:140,464,999...140,469,046
JBrowse link
negative regulation of hepatocyte differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Frzb frizzled-related protein ISO (MGI:MGI:4356222|PMID:19562671) RGD PMID:19562671 MGI:MGI:4356222 NCBI chr 3:67,635,604...67,668,772
Ensembl chr 3:67,635,607...67,668,772
JBrowse link
positive regulation of hepatocyte differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 IMP RGD PMID:19229878 RGD:8885195 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
JBrowse link
G Foxa3 forkhead box A3 IMP RGD PMID:9878541 RGD:2315086 NCBI chr 1:79,921,292...79,930,219
Ensembl chr 1:79,920,752...79,930,263
JBrowse link
G Mesp1 mesoderm posterior bHLH transcription factor 1 ISO (MGI:MGI:4441249|PMID:18593560) RGD PMID:18593560 MGI:MGI:4441249 NCBI chr 1:141,532,390...141,533,908
Ensembl chr 1:141,532,390...141,533,908
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    developmental process 6812
      cellular developmental process 4443
        cell differentiation 4346
          epithelial cell differentiation 707
            hepatocyte differentiation 20
              negative regulation of hepatocyte differentiation 1
              positive regulation of hepatocyte differentiation 3
              regulation of hepatocyte differentiation + 4
Path 2
Term Annotations click to browse term
  biological_process 20014
    developmental process 6812
      anatomical structure development 6256
        multicellular organism development 5735
          system development 5272
            animal organ development 4027
              gland development 664
                liver development 262
                  hepatocyte differentiation 20
                    negative regulation of hepatocyte differentiation 1
                    positive regulation of hepatocyte differentiation 3
                    regulation of hepatocyte differentiation + 4
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.