Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of ERK1 and ERK2 cascade
go back to main search page
Accession:GO:0070373 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
Synonyms:exact_synonym: down regulation of ERK1 and ERK2 cascade;   downregulation of ERK1 and ERK2 cascade;   negative regulation of ERK1 and ERK2 signaling pathway;   negative regulation of ERK1 and ERK2 signalling pathway;   negative regulation of ERK1/2 cascade
 narrow_synonym: inhibition of ERK1 and ERK2 cascade;   negative regulation of ERK1 cascade;   negative regulation of ERK2 cascade;   negative regulation of MAPK1 cascade;   negative regulation of MAPK3 cascade
 broad_synonym: negative regulation of ERK cascade


show annotations for term's descendants           Sort by:
 
negative regulation of ERK1 and ERK2 cascade term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase ISO MGI:104738 (MGI:5449665|PMID:22729085) RGD PMID:22729085 MGI:5449665 NCBI chr 3:10,041,820...10,145,076
Ensembl chr 3:10,041,826...10,144,388
JBrowse link
G Ace2 angiotensin I converting enzyme 2 IMP RGD PMID:20703229 RGD:9685431 NCBI chr  X:32,050,734...32,095,860
Ensembl chr  X:32,049,931...32,096,016
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing ISO
ISS
(PMID:12070119)
GO_REF:0000024
RGD
UniProt
PMID:12070119 GO_REF:0000024 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Ankrd26 ankyrin repeat domain 26 ISO MGI:3774418 (MGI:5285770|PMID:21669876) RGD PMID:21669876 MGI:5285770 NCBI chr 4:150,548,656...150,616,928
Ensembl chr 4:150,547,467...150,616,895
JBrowse link
G Arrb1 arrestin, beta 1 IMP RGD PMID:19254952 RGD:5509898 NCBI chr 1:164,502,099...164,573,947
Ensembl chr 1:164,502,389...164,593,139
JBrowse link
G Atf3 activating transcription factor 3 ISO (MGI:5297260|PMID:22053207) RGD PMID:22053207 MGI:5297260 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Btn2a2 butyrophilin, subfamily 2, member A2 ISO (MGI:5520006|PMID:23589618) RGD PMID:23589618 MGI:5520006 NCBI chr17:43,867,243...43,878,734
Ensembl chr17:43,868,191...43,879,839
JBrowse link
G C1ql4 complement C1q like 4 ISO (MGI:5527130|PMID:23449976) RGD PMID:23449976 MGI:5527130 NCBI chr 7:140,766,517...140,771,415
Ensembl chr 7:140,767,737...140,770,647
JBrowse link
G Camk2n1 calcium/calmodulin-dependent protein kinase II inhibitor 1 ISO (PMID:18305109) RGD PMID:18305109 NCBI chr 5:156,876,706...156,878,486
Ensembl chr 5:156,876,706...156,878,486
JBrowse link
G Cav1 caveolin 1 IDA RGD PMID:20172952 RGD:6849300 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Chrna10 cholinergic receptor nicotinic alpha 10 subunit IMP RGD PMID:20505147 RGD:8549538 NCBI chr 1:167,206,722...167,212,199
Ensembl chr 1:167,206,722...167,210,919
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit IMP RGD PMID:20505147 RGD:8549538 NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196
JBrowse link
G Chrna9 cholinergic receptor nicotinic alpha 9 subunit IMP RGD PMID:20505147 RGD:8549538 NCBI chr14:43,883,450...43,890,171
Ensembl chr14:43,883,458...43,890,171
JBrowse link
G Cnksr3 Cnksr family member 3 ISS
ISO
GO_REF:0000024
(MGI:4457233|PMID:19567370)
UniProt
RGD
PMID:19567370 GO_REF:0000024 MGI:4457233 NCBI chr 1:43,789,797...43,884,267
Ensembl chr 1:43,789,791...43,884,267
JBrowse link
G Cryba1 crystallin, beta A1 IMP RGD PMID:21993393 RGD:10059647 NCBI chr10:65,160,777...65,167,504
Ensembl chr10:65,161,152...65,167,494
JBrowse link
G Csk C-terminal Src kinase IDA RGD PMID:9325302 RGD:2303720 NCBI chr 8:62,405,714...62,424,707
Ensembl chr 8:62,405,715...62,424,303
JBrowse link
G Dab2 DAB adaptor protein 2 IDA PMID:12473651 UniProt PMID:12473651 RGD:8553624 NCBI chr 2:55,747,353...55,768,848
Ensembl chr 2:55,747,318...55,768,270
JBrowse link
G Dab2ip DAB2 interacting protein IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:19903888)
Ensembl
UniProt
RGD
PMID:19903888 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:14,889,263...15,060,286
Ensembl chr 3:14,889,510...15,060,286
JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 IEA
ISO
GO_REF:0000107
(PMID:20551903)
Ensembl
RGD
PMID:20551903 GO_REF:0000107 NCBI chr11:72,164,566...72,378,895
Ensembl chr11:72,163,749...72,378,895
JBrowse link
G Dmd dystrophin ISO MGI:1856328 (MGI:3028267|PMID:14718391) RGD PMID:14718391 MGI:3028267 NCBI chr  X:51,149,358...53,519,271
Ensembl chr  X:51,286,737...53,519,259
JBrowse link
G Dusp1 dual specificity phosphatase 1 IMP RGD PMID:17437549 RGD:7771545 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
JBrowse link
G Dusp10 dual specificity phosphatase 10 ISO (MGI:5905244|PMID:25772234) RGD PMID:25772234 MGI:5905244 NCBI chr13:104,284,660...104,321,455
Ensembl chr13:104,284,660...104,321,455
JBrowse link
G Dusp26 dual specificity phosphatase 26 ISO (PMID:16581800) RGD PMID:16581800 NCBI chr16:64,798,782...64,806,459
Ensembl chr16:64,798,778...64,806,050
JBrowse link
G Dusp29 dual specificity phosphatase 29 ISS
ISO
GO_REF:0000024
(MGI:6450308|PMID:32639872)
UniProt
RGD
PMID:32639872 GO_REF:0000024 MGI:6450308 NCBI chr15:2,766,929...2,806,573
Ensembl chr15:2,766,710...2,806,536
JBrowse link
G Dusp3 dual specificity phosphatase 3 ISO
IBA
(PMID:11085983)
PMID:21873635
RGD PMID:11085983, PMID:21873635 RGD:13792537 NCBI chr10:89,904,578...89,918,296
Ensembl chr10:89,904,560...89,918,427
JBrowse link
G Dusp4 dual specificity phosphatase 4 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:7535768)
Ensembl
UniProt
RGD
PMID:7535768 GO_REF:0000024 GO_REF:0000107 NCBI chr16:61,080,767...61,090,973
Ensembl chr16:61,078,175...61,091,169
JBrowse link
G Dusp6 dual specificity phosphatase 6 IDA
IBA
ISO
PMID:21873635
(PMID:18771677)
RGD PMID:18771677, PMID:8626780, PMID:21873635 RGD:728656, RGD:13792537 NCBI chr 7:41,475,163...41,479,393
Ensembl chr 7:41,475,163...41,479,392
JBrowse link
G Dusp9 dual specificity phosphatase 9 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:157,168,143...157,172,068
Ensembl chr  X:157,168,144...157,172,068
JBrowse link
G Eif3a eukaryotic translation initiation factor 3, subunit A IMP RGD PMID:22025682 RGD:10755441 NCBI chr 1:282,139,809...282,170,017
Ensembl chr 1:282,139,823...282,170,017
JBrowse link
G Emilin1 elastin microfibril interfacer 1 ISO (MGI:5605894|PMID:25056700) RGD PMID:25056700 MGI:5605894 NCBI chr 6:26,821,249...26,829,013
Ensembl chr 6:26,821,255...26,828,972
JBrowse link
G Ephb2 Eph receptor B2 ISO (MGI:5905277|PMID:11585923) RGD PMID:11585923 MGI:5905277 NCBI chr 5:155,024,478...155,143,539
Ensembl chr 5:155,022,493...155,204,456
JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 IDA RGD PMID:19204184 RGD:9685562 NCBI chr 5:167,951,564...167,966,011
Ensembl chr 5:167,952,728...167,966,009
JBrowse link
G Ezr ezrin ISO (PMID:20551903) RGD PMID:20551903 NCBI chr 1:47,287,872...47,331,412
Ensembl chr 1:47,287,874...47,331,412
JBrowse link
G Fbln1 fibulin 1 ISO (PMID:11792823) RGD PMID:11792823 NCBI chr 7:126,096,793...126,176,468
Ensembl chr 7:126,096,793...126,176,468
JBrowse link
G Flcn folliculin ISS
ISO
GO_REF:0000024
MGI:3774414|MGI:4348628 (MGI:3772618|PMID:18182616), (MGI:5050037|PMID:21258407)
UniProt
RGD
PMID:18182616 PMID:21258407 GO_REF:0000024 MGI:3772618 MGI:5050037 NCBI chr10:46,153,185...46,172,331
Ensembl chr10:46,153,188...46,172,309
JBrowse link
G Gbp1 guanylate binding protein 1 ISO (PMID:24337748) RGD PMID:24337748 NCBI chr 2:248,343,334...248,423,402
Ensembl chr 2:248,398,917...248,409,570
JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 ISO
IEA
(PMID:23840305)
GO_REF:0000107
RGD
Ensembl
PMID:23840305 GO_REF:0000107 NCBI chr12:17,309,122...17,315,267
Ensembl chr12:17,309,834...17,311,112
JBrowse link
G Gstp1 glutathione S-transferase pi 1 ISO
ISS
(PMID:11408560)
(MGI:5009411|PMID:16023107)
GO_REF:0000024
RGD
BHF-UCL
PMID:11408560 PMID:16023107 GO_REF:0000024 MGI:5009411 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Igf1 insulin-like growth factor 1 ISO MGI:96787 (MGI:3640953|PMID:16691571) RGD PMID:16691571 MGI:3640953 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Itgb1bp1 integrin subunit beta 1 binding protein 1 ISO (PMID:20616313) RGD PMID:20616313 NCBI chr 6:43,348,927...43,363,633
Ensembl chr 6:43,348,958...43,363,335
JBrowse link
G Klf4 Kruppel like factor 4 IMP PMID:19531492 UniProt PMID:19531492 RGD:8553301 NCBI chr 5:72,283,311...72,287,669
Ensembl chr 5:72,283,313...72,287,669
JBrowse link
G Lif LIF, interleukin 6 family cytokine IEA
ISO
GO_REF:0000107
MGI:96432 (MGI:3640953|PMID:16691571)
Ensembl
RGD
PMID:16691571 GO_REF:0000107 MGI:3640953 NCBI chr14:84,482,652...84,500,574
Ensembl chr14:84,482,674...84,500,642
JBrowse link
G Lmo3 LIM domain only 3 ISO (PMID:23823477) RGD PMID:23823477 NCBI chr 4:172,942,023...173,005,630
Ensembl chr 4:172,942,020...173,005,634
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase ISS
ISO
GO_REF:0000024
(MGI:2687173|PMID:14525964), (MGI:3044099|PMID:14726379)
UniProt
RGD
PMID:14525964 PMID:14726379 GO_REF:0000024 MGI:2687173 MGI:3044099 NCBI chr 5:16,526,058...16,642,648
Ensembl chr 5:16,526,058...16,642,648
JBrowse link
G Ndrg2 NDRG family member 2 IEA
ISO
GO_REF:0000107
(MGI:4835375|PMID:19815093)
Ensembl
RGD
PMID:19815093 GO_REF:0000107 MGI:4835375 NCBI chr15:28,305,820...28,314,459
Ensembl chr15:28,305,821...28,314,459
JBrowse link
G Nlrp12 NLR family, pyrin domain containing 12 ISO MGI:4836357 (MGI:5436198|PMID:22503542) RGD PMID:22503542 MGI:5436198 NCBI chr 1:64,506,750...64,543,908
Ensembl chr 1:64,506,735...64,534,912
JBrowse link
G Nlrp6 NLR family, pyrin domain containing 6 ISO (MGI:5432950|PMID:22763455) RGD PMID:22763455 MGI:5432950 NCBI chr 1:213,676,954...213,683,114
Ensembl chr 1:213,686,046...213,691,943
JBrowse link
G Phb prohibitin ISO (PMID:24732013) RGD PMID:24732013 NCBI chr10:83,476,107...83,488,878
Ensembl chr10:83,476,107...83,488,878
JBrowse link
G Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 IMP PMID:20819118 UniProt PMID:20819118 RGD:8693633 NCBI chr13:26,145,989...26,394,505
Ensembl chr13:26,172,243...26,394,505
JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 ISO (PMID:20179103) RGD PMID:20179103 NCBI chr 8:21,669,236...21,680,615
Ensembl chr 8:21,669,236...21,680,615
JBrowse link
G Psca prostate stem cell antigen ISO (PMID:25680266) RGD PMID:25680266 NCBI chr 7:116,090,189...116,091,955
Ensembl chr 7:116,090,189...116,091,955
JBrowse link
G Pten phosphatase and tensin homolog ISO (PMID:19962668) RGD PMID:19962668 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 ISO UniProtKB:P97333 (MGI:5490930|PMID:23639442) RGD PMID:23639442 MGI:5490930 NCBI chr 3:164,665,462...164,711,936
Ensembl chr 3:164,665,532...164,711,848
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 ISS
ISO
GO_REF:0000024
(MGI:3530208|PMID:15696169)
UniProt
RGD
PMID:15696169 GO_REF:0000024 MGI:3530208 NCBI chr18:63,415,298...63,489,240
Ensembl chr18:63,415,306...63,488,027
JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C ISO UniProtKB:P06240 (MGI:3530407|PMID:15661907) RGD PMID:15661907 MGI:3530407 NCBI chr13:55,061,561...55,174,150
Ensembl chr13:55,061,562...55,173,692
JBrowse link
G Ptprr protein tyrosine phosphatase, receptor type, R IEA
ISO
GO_REF:0000107
(PMID:21724833)
Ensembl
RGD
PMID:21724833 GO_REF:0000107 NCBI chr 7:59,039,717...59,325,925
Ensembl chr 7:59,039,720...59,325,947
JBrowse link
G Ranbp9 RAN binding protein 9 ISO (PMID:23118896) RGD PMID:23118896 NCBI chr17:24,020,874...24,103,771
Ensembl chr17:24,021,736...24,103,515
JBrowse link
G Rapgef1 Rap guanine nucleotide exchange factor 1 ISO MGI:95516 (MGI:3701731|PMID:16858399) RGD PMID:16858399 MGI:3701731 NCBI chr 3:8,189,594...8,307,077
Ensembl chr 3:8,192,575...8,304,976
JBrowse link
G RGD1565059 similar to hypothetical protein E130311K13 ISO (PMID:20680465) RGD PMID:20680465 NCBI chr 2:154,485,133...154,508,907
Ensembl chr 2:154,486,012...154,508,877
JBrowse link
G Rgs14 regulator of G-protein signaling 14 IDA PMID:19878719 UniProt PMID:19878719 RGD:8553779 NCBI chr17:9,777,925...9,792,007
Ensembl chr17:9,777,842...9,792,007
JBrowse link
G Rps6ka6 ribosomal protein S6 kinase A6 ISO (MGI:3041939|PMID:15121846) RGD PMID:15121846 MGI:3041939 NCBI chr  X:82,641,679...82,743,771
Ensembl chr  X:82,641,687...82,743,753
JBrowse link
G Sema6a semaphorin 6A ISO (PMID:21536891) RGD PMID:21536891 NCBI chr18:41,330,519...41,451,813
Ensembl chr18:41,333,551...41,389,510
JBrowse link
G Sirpa signal-regulatory protein alpha IEA
ISO
GO_REF:0000107
(MGI:3760575|PMID:17954568)
Ensembl
RGD
PMID:17954568 GO_REF:0000107 MGI:3760575 NCBI chr 3:122,113,735...122,152,478
Ensembl chr 3:122,114,108...122,152,477
JBrowse link
G Sirt3 sirtuin 3 IMP RGD PMID:23397292 RGD:9586042 NCBI chr 1:213,613,502...213,636,061
Ensembl chr 1:213,613,513...213,635,546
JBrowse link
G Slc9a3r1 SLC9A3 regulator 1 ISO (PMID:20012548) RGD PMID:20012548 NCBI chr10:103,713,045...103,730,145
Ensembl chr10:103,713,045...103,730,145
JBrowse link
G Smad4 SMAD family member 4 IEA
ISO
GO_REF:0000107
(MGI:3689643|PMID:16151019)
Ensembl
RGD
PMID:16151019 GO_REF:0000107 MGI:3689643 NCBI chr18:69,626,682...69,657,373
Ensembl chr18:69,627,757...69,671,199
JBrowse link
G Spred1 sprouty-related, EVH1 domain containing 1 ISO (MGI:5766647|PMID:26934179), (MGI:6414698|PMID:29501879) RGD PMID:26934179 PMID:29501879 MGI:5766647 MGI:6414698 NCBI chr 3:108,795,337...108,861,650
Ensembl chr 3:108,795,235...108,857,556
JBrowse link
G Spred2 sprouty-related, EVH1 domain containing 2 ISS
ISO
IEA
GO_REF:0000024
(MGI:6414698|PMID:29501879)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:29501879 GO_REF:0000024 GO_REF:0000107 MGI:6414698 NCBI chr14:104,268,362...104,290,206
Ensembl chr14:104,191,517...104,290,456
JBrowse link
G Spred3 sprouty-related, EVH1 domain containing 3 ISO (MGI:6414698|PMID:29501879) RGD PMID:29501879 MGI:6414698 NCBI chr 1:88,101,213...88,112,719
Ensembl chr 1:88,103,719...88,112,683
JBrowse link
G Spry1 sprouty RTK signaling antagonist 1 ISO MGI:1099809|MGI:1345138 (MGI:2154590|PMID:11585837), (MGI:3831894|PMID:19043405), (MGI:5052190|PMID:21764747), (MGI:6414698|PMID:29501879) RGD PMID:11585837 PMID:19043405 PMID:21764747 PMID:29501879 MGI:2154590 MGI:3831894 MGI:5052190 MGI:6414698 NCBI chr 2:124,400,689...124,405,331
Ensembl chr 2:124,400,679...124,405,331
JBrowse link
G Spry2 sprouty RTK signaling antagonist 2 ISO (PMID:20489163), (PMID:21536891)
MGI:1099809|MGI:1345139 (MGI:2154590|PMID:11585837), (MGI:5052190|PMID:21764747), (MGI:5693366|PMID:18508928), (MGI:6414698|PMID:29501879)
RGD PMID:11585837 PMID:18508928 PMID:20489163 PMID:21536891 PMID:21764747 PMID:29501879 MGI:2154590 MGI:5052190 MGI:5693366 MGI:6414698 NCBI chr15:90,172,769...90,177,823
Ensembl chr15:90,172,975...90,175,802
JBrowse link
G Spry4 sprouty RTK signaling antagonist 4 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr18:32,593,370...32,609,890
Ensembl chr18:32,594,958...32,609,864
JBrowse link
G Synj2bp synaptojanin 2 binding protein ISO
ISS
(PMID:24025447)
GO_REF:0000024
RGD
UniProt
PMID:24025447 GO_REF:0000024 NCBI chr 6:105,224,166...105,261,549
Ensembl chr 6:105,224,166...105,261,549
JBrowse link
G Tbc1d10c TBC1 domain family, member 10C ISO MGI:1932389 (MGI:5576870|PMID:23109291) RGD PMID:23109291 MGI:5576870 NCBI chr 1:219,431,094...219,439,102
Ensembl chr 1:219,431,997...219,438,779
JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 ISO
IEA
(PMID:19962668)
GO_REF:0000107
RGD
Ensembl
PMID:19962668 GO_REF:0000107 NCBI chr 7:23,543,125...23,594,170
Ensembl chr 7:23,544,215...23,594,133
JBrowse link
G Tlr4 toll-like receptor 4 IEA
ISO
GO_REF:0000107
(MGI:4421230|PMID:20051628)
Ensembl
RGD
PMID:20051628 GO_REF:0000107 MGI:4421230 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnip1 TNFAIP3 interacting protein 1 ISO
IBA
(PMID:12220502)
PMID:21873635
RGD PMID:12220502, PMID:21873635 RGD:13792537 NCBI chr10:40,255,776...40,303,092
Ensembl chr10:40,255,776...40,296,470
JBrowse link
G Vrk3 VRK serine/threonine kinase 3 ISO (MGI:3778226|PMID:18035061) RGD PMID:18035061 MGI:3778226 NCBI chr 1:100,755,622...100,783,008
Ensembl chr 1:100,755,682...100,783,004
JBrowse link
G Wnk2 WNK lysine deficient protein kinase 2 ISO (PMID:17667937) RGD PMID:17667937 NCBI chr17:15,923,508...16,032,271
Ensembl chr17:15,924,048...16,032,420
JBrowse link
G Xbp1 X-box binding protein 1 ISO (PMID:26315405) RGD PMID:26315405 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20030
    cellular process 18802
      signal transduction 7012
        intracellular signal transduction 2594
          MAPK cascade 831
            negative regulation of MAPK cascade 186
              negative regulation of ERK1 and ERK2 cascade 80
Path 2
Term Annotations click to browse term
  biological_process 20030
    biological regulation 13774
      regulation of biological process 13076
        regulation of cellular process 12564
          signal transduction 7012
            intracellular signal transduction 2594
              MAPK cascade 831
                regulation of MAPK cascade 756
                  negative regulation of MAPK cascade 186
                    negative regulation of ERK1 and ERK2 cascade 80
paths to the root