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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of ERK1 and ERK2 cascade
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Accession:GO:0070373 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
Synonyms:exact_synonym: down regulation of ERK1 and ERK2 cascade;   downregulation of ERK1 and ERK2 cascade;   negative regulation of ERK1 and ERK2 signaling pathway;   negative regulation of ERK1 and ERK2 signalling pathway;   negative regulation of ERK1/2 cascade
 narrow_synonym: inhibition of ERK1 and ERK2 cascade;   negative regulation of ERK1 cascade;   negative regulation of ERK2 cascade;   negative regulation of MAPK1 cascade;   negative regulation of MAPK3 cascade
 broad_synonym: negative regulation of ERK cascade


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negative regulation of ERK1 and ERK2 cascade term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase JBrowse link 3 10,041,820 10,145,076 RGD:1624291
G Ace2 angiotensin I converting enzyme 2 JBrowse link X 32,050,734 32,095,860 RGD:9685431
G Adipoq adiponectin, C1Q and collagen domain containing JBrowse link 11 81,330,845 81,344,488 RGD:1624291
RGD:1600115
G Ankrd26 ankyrin repeat domain 26 JBrowse link 4 150,548,656 150,616,928 RGD:1624291
G Arrb1 arrestin, beta 1 JBrowse link 1 164,502,099 164,573,947 RGD:5509898
G Atf3 activating transcription factor 3 JBrowse link 13 109,817,892 109,849,632 RGD:1624291
RGD:1600115
G Btn2a2 butyrophilin, subfamily 2, member A2 JBrowse link 17 43,867,243 43,878,734 RGD:1624291
RGD:1600115
G C1ql4 complement C1q like 4 JBrowse link 7 140,766,517 140,771,415 RGD:1624291
RGD:1600115
G Camk2n1 calcium/calmodulin-dependent protein kinase II inhibitor 1 JBrowse link 5 156,876,706 156,878,486 RGD:1624291
RGD:1600115
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:6849300
G Chrna10 cholinergic receptor nicotinic alpha 10 subunit JBrowse link 1 167,206,722 167,212,199 RGD:8549538
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit JBrowse link 1 123,897,341 124,039,263 RGD:8549538
G Chrna9 cholinergic receptor nicotinic alpha 9 subunit JBrowse link 14 43,883,450 43,890,171 RGD:8549538
G Cnksr3 Cnksr family member 3 JBrowse link 1 43,789,797 43,884,267 RGD:1624291
RGD:1600115
G Cryba1 crystallin, beta A1 JBrowse link 10 65,160,777 65,167,504 RGD:10059647
G Csk C-terminal Src kinase JBrowse link 8 62,405,714 62,424,707 RGD:2303720
G Dab2 DAB adaptor protein 2 JBrowse link 2 55,747,353 55,768,848 RGD:8553624
G Dab2ip DAB2 interacting protein JBrowse link 3 14,889,263 15,060,286 RGD:1600115
RGD:1624291
G Dlg1 discs large MAGUK scaffold protein 1 JBrowse link 11 72,164,566 72,378,895 RGD:1600115
RGD:1624291
G Dmd dystrophin JBrowse link X 51,149,358 53,519,271 RGD:1624291
RGD:1600115
G Dusp1 dual specificity phosphatase 1 JBrowse link 10 16,970,642 16,973,425 RGD:7771545
G Dusp10 dual specificity phosphatase 10 JBrowse link 13 104,284,660 104,321,455 RGD:1624291
RGD:1600115
G Dusp26 dual specificity phosphatase 26 JBrowse link 16 64,798,782 64,806,459 RGD:1624291
RGD:1600115
G Dusp3 dual specificity phosphatase 3 JBrowse link 10 89,904,578 89,918,296 RGD:1624291
RGD:13792537
G Dusp4 dual specificity phosphatase 4 JBrowse link 16 61,080,767 61,090,973 RGD:1600115
RGD:1624291
G Dusp6 dual specificity phosphatase 6 JBrowse link 7 41,475,163 41,479,393 RGD:728656
RGD:13792537
RGD:1624291
G Eif3a eukaryotic translation initiation factor 3, subunit A JBrowse link 1 282,139,809 282,170,017 RGD:10755441
G Emilin1 elastin microfibril interfacer 1 JBrowse link 6 26,821,249 26,829,013 RGD:1600115
RGD:1624291
G Ephb2 Eph receptor B2 JBrowse link 5 155,024,478 155,143,539 RGD:1624291
RGD:1600115
G Errfi1 ERBB receptor feedback inhibitor 1 JBrowse link 5 167,951,564 167,966,011 RGD:9685562
G Ezr ezrin JBrowse link 1 47,287,872 47,331,412 RGD:1624291
RGD:1600115
G Fbln1 fibulin 1 JBrowse link 7 126,096,793 126,176,468 RGD:1624291
RGD:1600115
G Flcn folliculin JBrowse link 10 46,153,185 46,172,331 RGD:1600115
RGD:1624291
G Gbp1 guanylate binding protein 1 JBrowse link 2 248,343,334 248,423,402 RGD:1624291
G Gper1 G protein-coupled estrogen receptor 1 JBrowse link 12 17,309,122 17,315,267 RGD:1624291
RGD:1600115
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:1624291
RGD:1600115
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:1624291
G Itgb1bp1 integrin subunit beta 1 binding protein 1 JBrowse link 6 43,348,927 43,363,633 RGD:1624291
RGD:1600115
G Klf4 Kruppel like factor 4 JBrowse link 5 72,283,311 72,287,669 RGD:8553301
G Lif LIF, interleukin 6 family cytokine JBrowse link 14 84,482,652 84,500,574 RGD:1624291
RGD:1600115
G Lmo3 LIM domain only 3 JBrowse link 4 172,942,023 173,005,630 RGD:1624291
RGD:1600115
G Lyn LYN proto-oncogene, Src family tyrosine kinase JBrowse link 5 16,526,058 16,642,648 RGD:1600115
RGD:1624291
G Ndrg2 NDRG family member 2 JBrowse link 15 28,305,820 28,314,459 RGD:1624291
RGD:1600115
G Nlrp12 NLR family, pyrin domain containing 12 JBrowse link 1 64,506,750 64,543,908 RGD:1624291
RGD:1600115
G Nlrp6 NLR family, pyrin domain containing 6 JBrowse link 1 213,676,954 213,683,114 RGD:1624291
G Phb prohibitin JBrowse link 10 83,476,107 83,488,878 RGD:1624291
G Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 JBrowse link 13 26,145,989 26,394,505 RGD:8693633
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 JBrowse link 8 21,669,236 21,680,615 RGD:1624291
RGD:1600115
G Psca prostate stem cell antigen JBrowse link 7 116,090,189 116,091,955 RGD:1624291
RGD:1600115
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:1624291
RGD:1600115
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 JBrowse link 3 164,665,462 164,711,936 RGD:1624291
RGD:1600115
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 JBrowse link 18 63,415,298 63,489,240 RGD:1624291
RGD:1600115
G Ptprc protein tyrosine phosphatase, receptor type, C JBrowse link 13 55,061,561 55,174,150 RGD:1624291
G Ptprr protein tyrosine phosphatase, receptor type, R JBrowse link 7 59,039,717 59,325,925 RGD:1600115
RGD:1624291
G Ranbp9 RAN binding protein 9 JBrowse link 17 24,020,874 24,103,771 RGD:1624291
RGD:1600115
G Rapgef1 Rap guanine nucleotide exchange factor 1 JBrowse link 3 8,189,594 8,307,077 RGD:1624291
RGD:1600115
G RGD1565059 similar to hypothetical protein E130311K13 JBrowse link 2 154,485,133 154,508,907 RGD:1624291
RGD:1600115
G Rgs14 regulator of G-protein signaling 14 JBrowse link 17 9,777,925 9,792,007 RGD:8553779
G Rps6ka6 ribosomal protein S6 kinase A6 JBrowse link X 82,641,679 82,743,771 RGD:1624291
G Sema6a semaphorin 6A JBrowse link 18 41,330,519 41,451,813 RGD:1624291
G Sirpa signal-regulatory protein alpha JBrowse link 3 122,113,735 122,152,478 RGD:1624291
RGD:1600115
G Sirt3 sirtuin 3 JBrowse link 1 213,613,502 213,636,061 RGD:9586042
G Slc9a3r1 SLC9A3 regulator 1 JBrowse link 10 103,713,045 103,730,145 RGD:1624291
RGD:1600115
G Smad4 SMAD family member 4 JBrowse link 18 69,626,682 69,657,373 RGD:1624291
RGD:1600115
G Spred1 sprouty-related, EVH1 domain containing 1 JBrowse link 3 108,795,337 108,861,650 RGD:1600115
RGD:1624291
G Spry1 sprouty RTK signaling antagonist 1 JBrowse link 2 124,400,689 124,405,331 RGD:1624291
RGD:1600115
G Spry2 sprouty RTK signaling antagonist 2 JBrowse link 15 90,172,769 90,177,823 RGD:1624291
RGD:1600115
G Spry4 sprouty RTK signaling antagonist 4 JBrowse link 18 32,593,370 32,609,890 RGD:1600115
G Synj2bp synaptojanin 2 binding protein JBrowse link 6 105,224,166 105,261,549 RGD:1624291
RGD:1600115
G Tbc1d10c TBC1 domain family, member 10C JBrowse link 1 219,431,094 219,439,102 RGD:1624291
RGD:1600115
G Timp3 TIMP metallopeptidase inhibitor 3 JBrowse link 7 23,543,125 23,594,170 RGD:1624291
RGD:1600115
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:1624291
RGD:1600115
G Tnip1 TNFAIP3 interacting protein 1 JBrowse link 10 40,255,776 40,303,092 RGD:1624291
RGD:13792537
G Vrk3 VRK serine/threonine kinase 3 JBrowse link 1 100,755,622 100,783,008 RGD:1624291
RGD:1600115
G Wnk2 WNK lysine deficient protein kinase 2 JBrowse link 17 15,923,508 16,032,271 RGD:1624291
RGD:1600115
G Xbp1 X-box binding protein 1 JBrowse link 14 85,753,736 85,758,820 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19312
    cellular process 17222
      signal transduction 6875
        signal transduction by protein phosphorylation 874
          MAPK cascade 854
            negative regulation of MAPK cascade 181
              negative regulation of ERK1 and ERK2 cascade 76
Path 2
Term Annotations click to browse term
  biological_process 19312
    metabolic process 11535
      organic substance metabolic process 10932
        macromolecule metabolic process 9412
          protein metabolic process 5975
            protein modification process 3864
              cellular protein modification process 3864
                protein phosphorylation 1961
                  signal transduction by protein phosphorylation 874
                    MAPK cascade 854
                      regulation of MAPK cascade 795
                        negative regulation of MAPK cascade 181
                          negative regulation of ERK1 and ERK2 cascade 76
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.