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ONTOLOGY REPORT - ANNOTATIONS


Term:ERK5 cascade
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Accession:GO:0070375 term browser browse the term
Definition:An intracellular protein kinase cascade containing at least ERK5 (also called BMK1; a MAPK), a MEK (a MAPKK) and a MAP3K. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
Synonyms:exact_synonym: BMK cascade;   BMK signaling pathway;   BMK signalling pathway;   BMK1 cascade;   ERK5 signaling pathway;   MAPK7 cascade;   big MAP kinase signaling cascade;   extracellular signal-regulated kinase 5 cascade


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ERK5 cascade term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Map2k5 mitogen activated protein kinase kinase 5 JBrowse link 8 68,055,976 68,282,656 RGD:1582263
G Mapk7 mitogen-activated protein kinase 7 JBrowse link 10 47,768,592 47,775,130 RGD:2298794
G Mef2a myocyte enhancer factor 2a JBrowse link 1 128,207,715 128,341,681 RGD:1600115
RGD:1624291
negative regulation of ERK5 cascade term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mapk7 mitogen-activated protein kinase 7 JBrowse link 10 47,768,592 47,775,130 RGD:1624291
positive regulation of ERK5 cascade term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alkal1 ALK and LTK ligand 1 JBrowse link 5 12,896,136 12,925,571 RGD:1624291
RGD:13792537
RGD:1600115
G Alkal2 ALK and LTK ligand 2 JBrowse link 6 49,824,725 49,834,921 RGD:1624291
RGD:1600115
RGD:13792537

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19317
    signaling 7394
      signal transduction 6875
        intracellular signal transduction 2629
          MAPK cascade 854
            ERK5 cascade 5
              negative regulation of ERK5 cascade 1
              positive regulation of ERK5 cascade 2
              regulation of ERK5 cascade + 3
Path 2
Term Annotations click to browse term
  biological_process 19317
    metabolic process 11540
      nitrogen compound metabolic process 9888
        organonitrogen compound metabolic process 6848
          protein metabolic process 5975
            protein modification process 3864
              cellular protein modification process 3864
                protein phosphorylation 1961
                  signal transduction by protein phosphorylation 874
                    MAPK cascade 854
                      ERK5 cascade 5
                        negative regulation of ERK5 cascade 1
                        positive regulation of ERK5 cascade 2
                        regulation of ERK5 cascade + 3
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.