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ONTOLOGY REPORT - ANNOTATIONS


Term:nucleotide-binding oligomerization domain containing signaling pathway
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Accession:GO:0070423 term browser browse the term
Definition:Any series of molecular signals generated as a consequence of binding to a nucleotide-binding oligomerization domain containing (NOD) protein.
Synonyms:exact_synonym: NOD signaling pathway;   nucleotide-binding oligomerization domain containing signalling pathway


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negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TNFAIP3 TNF alpha induced protein 3 ISO (MGI:MGI:3777503|PMID:18342009) BHF-UCL PMID:18342009 MGI:MGI:3777503 NCBI chr 6:135,617,465...135,634,085
Ensembl chr 6:139,705,255...139,720,819
JBrowse link
negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ERBIN erbb2 interacting protein ISO (MGI:MGI:5640951|PMID:16203728)
(PMID:16203728)
UniProtKB PMID:16203728 MGI:MGI:5640951 NCBI chr 5:47,929,305...48,081,381
Ensembl chr 5:49,589,418...49,676,689
JBrowse link
G PTPN22 protein tyrosine phosphatase non-receptor type 22 ISO (MGI:MGI:5640942|PMID:23991106)
(PMID:23991106)
UniProtKB PMID:23991106 MGI:MGI:5640942 NCBI chr 1:88,685,736...88,743,164
Ensembl chr 1:123,734,511...123,790,830
JBrowse link
G TNFAIP3 TNF alpha induced protein 3 ISO (MGI:MGI:3777503|PMID:18342009) BHF-UCL PMID:18342009 MGI:MGI:3777503 NCBI chr 6:135,617,465...135,634,085
Ensembl chr 6:139,705,255...139,720,819
JBrowse link
nucleotide-binding oligomerization domain containing 1 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NFKBIA NFKB inhibitor alpha ISO (MGI:MGI:3775161|PMID:18261938) MGI PMID:18261938 MGI:MGI:3775161 NCBI chr14:16,155,331...16,158,588 JBrowse link
G RIPK2 receptor interacting serine/threonine kinase 2 ISO (MGI:MGI:2176422|PMID:11894098) MGI PMID:11894098 MGI:MGI:2176422 NCBI chr 8:86,447,216...86,480,511
Ensembl chr 8:88,398,468...88,456,268
JBrowse link
nucleotide-binding oligomerization domain containing 2 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INAVA innate immunity activator ISO (PMID:28436939) UniProtKB PMID:28436939 NCBI chr 1:176,491,264...176,514,719
Ensembl chr 1:180,794,646...180,818,853
JBrowse link
G IRGM immunity related GTPase M ISO (PMID:25891078) UniProtKB PMID:25891078 NCBI chr 5:146,274,097...146,329,979
Ensembl chr 5:152,278,581...152,308,182
JBrowse link
G LACC1 laccase domain containing 1 ISO (PMID:31875558) UniProt PMID:31875558 NCBI chr13:25,047,306...25,063,644
Ensembl chr 3:198,998,153...199,012,230
JBrowse link
G NFKBIA NFKB inhibitor alpha ISO (MGI:MGI:3775161|PMID:18261938) MGI PMID:18261938 MGI:MGI:3775161 NCBI chr14:16,155,331...16,158,588 JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 ISO (PMID:12527755), (PMID:23806334)
(MGI:MGI:5562512|PMID:23892723)
MGI PMID:12527755, PMID:23806334, PMID:23892723 MGI:MGI:5562512 NCBI chr16:30,955,976...30,995,451
Ensembl chr16:49,837,891...49,873,773
JBrowse link
G OTULIN OTU deubiquitinase with linear linkage specificity ISO (PMID:23806334) UniProtKB PMID:23806334 NCBI chr 5:14,969,432...15,017,666
Ensembl chr 5:14,809,539...14,837,750
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit ISO (PMID:12527755) MGI PMID:12527755 NCBI chr11:61,012,839...61,022,225
Ensembl chr11:64,347,859...64,356,868
JBrowse link
G RIPK2 receptor interacting serine/threonine kinase 2 ISO (PMID:23806334)
(MGI:MGI:2176422|PMID:11894098)
UniProtKB
MGI
PMID:11894098, PMID:23806334 MGI:MGI:2176422 NCBI chr 8:86,447,216...86,480,511
Ensembl chr 8:88,398,468...88,456,268
JBrowse link
positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC15A4 solute carrier family 15 member 4 ISO (MGI:MGI:6278628|PMID:21277849), (MGI:MGI:6450424|PMID:19570976) UniProt PMID:19570976, PMID:21277849 MGI:MGI:6278628, MGI:MGI:6450424 NCBI chr12:126,418,071...126,448,917 JBrowse link
G SLC46A2 solute carrier family 46 member 2 ISO (PMID:28539433) FlyBase PMID:28539433 NCBI chr 9:84,001,056...84,013,231
Ensembl chr 9:112,154,001...112,165,906
JBrowse link
G TLR4 toll like receptor 4 ISO (MGI:MGI:3775161|PMID:18261938) MGI PMID:18261938 MGI:MGI:3775161 NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711
JBrowse link
positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSPA1A heat shock protein family A (Hsp70) member 1A ISO (PMID:24790089) UniProtKB PMID:24790089 NCBI chr 6:31,476,710...31,491,411 JBrowse link
G PELI3 pellino E3 ubiquitin protein ligase family member 3 ISO (MGI:MGI:5562512|PMID:23892723) MGI PMID:23892723 MGI:MGI:5562512 NCBI chr11:61,824,463...61,834,930
Ensembl chr11:65,148,441...65,159,211
JBrowse link
G SLC15A3 solute carrier family 15 member 3 ISO (MGI:MGI:5571205|PMID:24695226) UniProt PMID:24695226 MGI:MGI:5571205 NCBI chr11:56,200,278...56,215,451
Ensembl chr11:59,640,970...59,655,535
JBrowse link
G SLC15A4 solute carrier family 15 member 4 ISO (MGI:MGI:5571205|PMID:24695226) UniProt PMID:24695226 MGI:MGI:5571205 NCBI chr12:126,418,071...126,448,917 JBrowse link
G TLR4 toll like receptor 4 ISO (MGI:MGI:3775161|PMID:18261938) MGI PMID:18261938 MGI:MGI:3775161 NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711
JBrowse link
regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PELI3 pellino E3 ubiquitin protein ligase family member 3 ISO (MGI:MGI:5562512|PMID:23892723) MGI PMID:23892723 MGI:MGI:5562512 NCBI chr11:61,824,463...61,834,930
Ensembl chr11:65,148,441...65,159,211
JBrowse link
regulation of nucleotide-binding oligomerization domain containing signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC15A2 solute carrier family 15 member 2 ISO (MGI:MGI:6192142|PMID:29784761) UniProt PMID:29784761 MGI:MGI:6192142 NCBI chr 3:118,996,023...119,044,423
Ensembl chr 3:125,902,978...125,951,963
JBrowse link
G SLC15A4 solute carrier family 15 member 4 ISO (MGI:MGI:6192142|PMID:29784761) UniProt PMID:29784761 MGI:MGI:6192142 NCBI chr12:126,418,071...126,448,917 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12529
    signaling 4286
      signal transduction 3809
        pattern recognition receptor signaling pathway 148
          cytoplasmic pattern recognition receptor signaling pathway 49
            nucleotide-binding oligomerization domain containing signaling pathway 18
              negative regulation of nucleotide-binding oligomerization domain containing signaling pathway + 3
              nucleotide-binding oligomerization domain containing 1 signaling pathway + 7
              nucleotide-binding oligomerization domain containing 2 signaling pathway + 16
              positive regulation of nucleotide-binding oligomerization domain containing signaling pathway + 6
              regulation of nucleotide-binding oligomerization domain containing signaling pathway + 10
Path 2
Term Annotations click to browse term
  biological_process 12529
    biological regulation 9138
      regulation of biological process 8652
        regulation of cellular process 8181
          signal transduction 3809
            intracellular receptor signaling pathway 211
              cytoplasmic pattern recognition receptor signaling pathway 49
                nucleotide-binding oligomerization domain containing signaling pathway 18
                  negative regulation of nucleotide-binding oligomerization domain containing signaling pathway + 3
                  nucleotide-binding oligomerization domain containing 1 signaling pathway + 7
                  nucleotide-binding oligomerization domain containing 2 signaling pathway + 16
                  positive regulation of nucleotide-binding oligomerization domain containing signaling pathway + 6
                  regulation of nucleotide-binding oligomerization domain containing signaling pathway + 10
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.