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ONTOLOGY REPORT - ANNOTATIONS


Term:nucleotide-binding oligomerization domain containing signaling pathway
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Accession:GO:0070423 term browser browse the term
Definition:Any series of molecular signals generated as a consequence of binding to a nucleotide-binding oligomerization domain containing (NOD) protein.
Synonyms:exact_synonym: NOD signaling pathway;   nucleotide-binding oligomerization domain containing signalling pathway


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negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnfaip3 TNF alpha induced protein 3 ISO (MGI:MGI:3777503|PMID:18342009) BHF-UCL PMID:18342009 MGI:MGI:3777503 NCBI chrNW_004936560:5,124,955...5,138,988 JBrowse link
negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Erbin erbb2 interacting protein ISO (PMID:16203728)
(MGI:MGI:5640951|PMID:16203728)
UniProtKB PMID:16203728 MGI:MGI:5640951 NCBI chrNW_004936480:3,155,934...3,293,224 JBrowse link
G Ptpn22 protein tyrosine phosphatase non-receptor type 22 ISO (PMID:23991106)
(MGI:MGI:5640942|PMID:23991106)
UniProtKB PMID:23991106 MGI:MGI:5640942 NCBI chrNW_004936690:2,180,804...2,232,869 JBrowse link
G Tnfaip3 TNF alpha induced protein 3 ISO (MGI:MGI:3777503|PMID:18342009) BHF-UCL PMID:18342009 MGI:MGI:3777503 NCBI chrNW_004936560:5,124,955...5,138,988 JBrowse link
nucleotide-binding oligomerization domain containing 1 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nfkbia NFKB inhibitor alpha ISO (MGI:MGI:3775161|PMID:18261938) MGI PMID:18261938 MGI:MGI:3775161 NCBI chrNW_004936494:9,537,793...9,541,187 JBrowse link
G Ripk2 receptor interacting serine/threonine kinase 2 ISO (MGI:MGI:2176422|PMID:11894098) MGI PMID:11894098 MGI:MGI:2176422 NCBI chrNW_004936544:3,606,925...3,653,248 JBrowse link
nucleotide-binding oligomerization domain containing 2 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Inava innate immunity activator ISO (PMID:28436939) UniProtKB PMID:28436939 NCBI chrNW_004936567:3,443,053...3,458,184 JBrowse link
G Irgm immunity related GTPase M ISO (PMID:25891078) UniProtKB PMID:25891078 NCBI chrNW_004936504:4,055,091...4,056,089 JBrowse link
G Nfkbia NFKB inhibitor alpha ISO (MGI:MGI:3775161|PMID:18261938) MGI PMID:18261938 MGI:MGI:3775161 NCBI chrNW_004936494:9,537,793...9,541,187 JBrowse link
G Nod2 nucleotide binding oligomerization domain containing 2 ISO (PMID:12527755), (PMID:23806334)
(MGI:MGI:5562512|PMID:23892723)
MGI PMID:12527755, PMID:23806334, PMID:23892723 MGI:MGI:5562512 NCBI chrNW_004936475:3,708,069...3,742,845 JBrowse link
G Otulin OTU deubiquitinase with linear linkage specificity ISO (PMID:23806334) UniProtKB PMID:23806334 NCBI chrNW_004936665:1,654,045...1,690,955 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO (PMID:12527755) MGI PMID:12527755 NCBI chrNW_004936599:3,800,142...3,810,583 JBrowse link
G Ripk2 receptor interacting serine/threonine kinase 2 ISO (PMID:23806334)
(MGI:MGI:2176422|PMID:11894098)
UniProtKB
MGI
PMID:11894098, PMID:23806334 MGI:MGI:2176422 NCBI chrNW_004936544:3,606,925...3,653,248 JBrowse link
positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc15a4 solute carrier family 15 member 4 ISO (MGI:MGI:6278628|PMID:21277849), (MGI:MGI:6450424|PMID:19570976) UniProt PMID:19570976, PMID:21277849 MGI:MGI:6278628, MGI:MGI:6450424 NCBI chrNW_004936660:481,772...493,567 JBrowse link
G Slc46a2 solute carrier family 46 member 2 ISO (PMID:28539433) FlyBase PMID:28539433 NCBI chrNW_004936559:670,239...674,061 JBrowse link
G Tlr4 toll like receptor 4 ISO (MGI:MGI:3775161|PMID:18261938) MGI PMID:18261938 MGI:MGI:3775161 NCBI chrNW_004936487:6,519,140...6,532,018 JBrowse link
positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hspa1a heat shock protein family A (Hsp70) member 1A ISO (PMID:24790089) UniProtKB PMID:24790089 NCBI chrNW_004936727:1,732,323...1,735,128 JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B ISO (PMID:24790089) UniProtKB PMID:24790089 NCBI chrNW_004936727:1,718,952...1,721,691 JBrowse link
G Peli3 pellino E3 ubiquitin protein ligase family member 3 ISO (MGI:MGI:5562512|PMID:23892723) MGI PMID:23892723 MGI:MGI:5562512 NCBI chrNW_004936599:3,099,256...3,110,566 JBrowse link
G Slc15a3 solute carrier family 15 member 3 ISO (MGI:MGI:5571205|PMID:24695226) UniProt PMID:24695226 MGI:MGI:5571205 NCBI chrNW_004936581:1,985,062...1,996,924 JBrowse link
G Slc15a4 solute carrier family 15 member 4 ISO (MGI:MGI:5571205|PMID:24695226) UniProt PMID:24695226 MGI:MGI:5571205 NCBI chrNW_004936660:481,772...493,567 JBrowse link
G Tlr4 toll like receptor 4 ISO (MGI:MGI:3775161|PMID:18261938) MGI PMID:18261938 MGI:MGI:3775161 NCBI chrNW_004936487:6,519,140...6,532,018 JBrowse link
regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Peli3 pellino E3 ubiquitin protein ligase family member 3 ISO (MGI:MGI:5562512|PMID:23892723) MGI PMID:23892723 MGI:MGI:5562512 NCBI chrNW_004936599:3,099,256...3,110,566 JBrowse link
regulation of nucleotide-binding oligomerization domain containing signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc15a2 solute carrier family 15 member 2 ISO (MGI:MGI:6192142|PMID:29784761) UniProt PMID:29784761 MGI:MGI:6192142 NCBI chrNW_004936536:8,280,537...8,316,011 JBrowse link
G Slc15a4 solute carrier family 15 member 4 ISO (MGI:MGI:6192142|PMID:29784761) UniProt PMID:29784761 MGI:MGI:6192142 NCBI chrNW_004936660:481,772...493,567 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11968
    signaling 4166
      signal transduction 3695
        pattern recognition receptor signaling pathway 144
          cytoplasmic pattern recognition receptor signaling pathway 49
            nucleotide-binding oligomerization domain containing signaling pathway 18
              negative regulation of nucleotide-binding oligomerization domain containing signaling pathway + 3
              nucleotide-binding oligomerization domain containing 1 signaling pathway + 7
              nucleotide-binding oligomerization domain containing 2 signaling pathway + 16
              positive regulation of nucleotide-binding oligomerization domain containing signaling pathway + 7
              regulation of nucleotide-binding oligomerization domain containing signaling pathway + 11
Path 2
Term Annotations click to browse term
  biological_process 11968
    biological regulation 8764
      regulation of biological process 8316
        regulation of cellular process 7896
          signal transduction 3695
            intracellular receptor signaling pathway 208
              cytoplasmic pattern recognition receptor signaling pathway 49
                nucleotide-binding oligomerization domain containing signaling pathway 18
                  negative regulation of nucleotide-binding oligomerization domain containing signaling pathway + 3
                  nucleotide-binding oligomerization domain containing 1 signaling pathway + 7
                  nucleotide-binding oligomerization domain containing 2 signaling pathway + 16
                  positive regulation of nucleotide-binding oligomerization domain containing signaling pathway + 7
                  regulation of nucleotide-binding oligomerization domain containing signaling pathway + 11
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.