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ONTOLOGY REPORT - ANNOTATIONS


Term:nucleotide-binding oligomerization domain containing 2 signaling pathway
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Accession:GO:0070431 term browser browse the term
Definition:Any series of molecular signals generated as a consequence of binding to nucleotide-binding oligomerization domain containing 2 (NOD2).
Synonyms:exact_synonym: NOD2 signaling pathway;   nucleotide-binding oligomerization domain containing 2 signalling pathway


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nucleotide-binding oligomerization domain containing 2 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Inava innate immunity activator ISO (PMID:28436939) RGD PMID:28436939 NCBI chr13:53,088,438...53,108,713
Ensembl chr13:53,088,439...53,108,713
JBrowse link
G Irgm immunity-related GTPase M ISO (PMID:25891078) RGD PMID:25891078 NCBI chr10:34,213,885...34,221,968
Ensembl chr10:34,213,936...34,221,928
JBrowse link
G Lacc1 laccase domain containing 1 ISO (PMID:31875558) RGD PMID:31875558 NCBI chr15:59,199,537...59,217,200
Ensembl chr15:59,209,829...59,215,803
JBrowse link
G Nfkbia NFKB inhibitor alpha ISO (MGI:MGI:3775161|PMID:18261938) RGD PMID:18261938 MGI:MGI:3775161 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 ISO (MGI:MGI:5562512|PMID:23892723)
(PMID:12527755), (PMID:23806334)
RGD PMID:12527755, PMID:23806334, PMID:23892723 MGI:MGI:5562512 NCBI chr19:19,342,061...19,389,366
Ensembl chr19:19,332,594...19,377,492
JBrowse link
G Otulin OTU deubiquitinase with linear linkage specificity ISO (PMID:23806334) RGD PMID:23806334 NCBI chr 2:80,267,724...80,293,204
Ensembl chr 2:80,269,587...80,293,181
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO (PMID:12527755) RGD PMID:12527755 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 ISO MGI:MGI:2660793 (MGI:MGI:2176422|PMID:11894098)
(PMID:23806334)
RGD PMID:11894098, PMID:23806334 MGI:MGI:2176422 NCBI chr 5:29,838,713...29,870,390
Ensembl chr 5:29,838,747...29,870,735
JBrowse link
negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Erbin erbb2 interacting protein ISO (PMID:16203728)
(MGI:MGI:5640951|PMID:16203728)
RGD PMID:16203728 MGI:MGI:5640951 NCBI chr 2:33,880,860...33,952,806
Ensembl chr 2:33,881,024...33,920,837
JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 ISO
IBA
(PMID:23991106)
PMID:21873635
(MGI:MGI:5640942|PMID:23991106)
RGD PMID:23991106, PMID:21873635 MGI:MGI:5640942, RGD:13792537 NCBI chr 2:206,342,066...206,390,348
Ensembl chr 2:206,342,066...206,390,348
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 ISO (MGI:MGI:3777503|PMID:18342009) RGD PMID:18342009 MGI:MGI:3777503 NCBI chr 1:14,401,103...14,416,369
Ensembl chr 1:14,402,913...14,412,807
JBrowse link
positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hspa1a heat shock protein family A (Hsp70) member 1A ISO UniProtKB:Q9HC29 (PMID:24790089) RGD PMID:24790089 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B ISO UniProtKB:Q9HC29 (PMID:24790089) RGD PMID:24790089 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Peli3 pellino E3 ubiquitin protein ligase family member 3 ISO (MGI:MGI:5562512|PMID:23892723) RGD PMID:23892723 MGI:MGI:5562512 NCBI chr 1:220,191,209...220,204,032
Ensembl chr 1:220,190,067...220,204,032
JBrowse link
G Slc15a3 solute carrier family 15 member 3 ISS
ISO
GO_REF:0000024
(MGI:MGI:5571205|PMID:24695226)
UniProt
RGD
PMID:24695226 GO_REF:0000024, MGI:MGI:5571205 NCBI chr 1:226,896,387...226,912,644
Ensembl chr 1:226,897,625...226,912,708
JBrowse link
G Slc15a4 solute carrier family 15 member 4 ISS
ISO
IEA
GO_REF:0000024
(MGI:MGI:5571205|PMID:24695226)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:24695226 GO_REF:0000024, GO_REF:0000107, MGI:MGI:5571205 NCBI chr12:32,753,824...32,773,277
Ensembl chr12:32,753,824...32,773,277
JBrowse link
G Tlr4 toll-like receptor 4 ISO
IEA
(MGI:MGI:3775161|PMID:18261938)
GO_REF:0000107
RGD
Ensembl
PMID:18261938 GO_REF:0000107, MGI:MGI:3775161 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    signaling 7588
      signal transduction 7015
        pattern recognition receptor signaling pathway 160
          cytoplasmic pattern recognition receptor signaling pathway 51
            nucleotide-binding oligomerization domain containing signaling pathway 19
              nucleotide-binding oligomerization domain containing 2 signaling pathway 17
                negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway 3
                positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway 6
                regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway + 9
Path 2
Term Annotations click to browse term
  biological_process 20014
    biological regulation 13759
      regulation of biological process 13071
        regulation of cellular process 12560
          signal transduction 7015
            intracellular receptor signaling pathway 255
              cytoplasmic pattern recognition receptor signaling pathway 51
                nucleotide-binding oligomerization domain containing signaling pathway 19
                  nucleotide-binding oligomerization domain containing 2 signaling pathway 17
                    negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway 3
                    positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway 6
                    regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway + 9
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.