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ONTOLOGY REPORT - ANNOTATIONS


Term:nucleotide-binding oligomerization domain containing 2 signaling pathway
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Accession:GO:0070431 term browser browse the term
Definition:Any series of molecular signals generated as a consequence of binding to nucleotide-binding oligomerization domain containing 2 (NOD2).
Synonyms:exact_synonym: NOD2 signaling pathway;   nucleotide-binding oligomerization domain containing 2 signalling pathway


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nucleotide-binding oligomerization domain containing 2 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INAVA innate immunity activator IMP (PMID:28436939) UniProtKB PMID:28436939 NCBI chr 1:200,891,074...200,915,742
Ensembl chr 1:200,891,048...200,915,742
JBrowse link
G IRGM immunity related GTPase M IMP (PMID:25891078) UniProtKB PMID:25891078 NCBI chr 5:150,846,521...150,902,402
Ensembl chr 5:150,846,523...150,900,736
JBrowse link
G LACC1 laccase domain containing 1 IDA (PMID:31875558) UniProt PMID:31875558 NCBI chr13:43,879,178...43,893,932
Ensembl chr13:43,879,284...43,893,932
JBrowse link
G NFKBIA NFKB inhibitor alpha ISO (MGI:MGI:3775161|PMID:18261938) MGI PMID:18261938 MGI:MGI:3775161 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749
JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 IDA (PMID:12527755), (PMID:23806334) MGI PMID:12527755, PMID:23806334 NCBI chr16:50,693,587...50,733,077
Ensembl chr16:50,693,588...50,734,041
JBrowse link
G OTULIN OTU deubiquitinase with linear linkage specificity IMP (PMID:23806334) UniProtKB PMID:23806334 NCBI chr 5:14,660,794...14,716,552
Ensembl chr 5:14,664,664...14,699,850
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit IDA (PMID:12527755) MGI PMID:12527755 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G RIPK2 receptor interacting serine/threonine kinase 2 IDA (PMID:23806334) UniProtKB PMID:23806334 NCBI chr 8:89,757,816...89,791,064
Ensembl chr 8:89,757,806...89,791,064
JBrowse link
negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ERBIN erbb2 interacting protein IMP (PMID:16203728) UniProtKB PMID:16203728 NCBI chr 5:65,926,575...66,082,546
Ensembl chr 5:65,926,475...66,082,549
JBrowse link
G PTPN22 protein tyrosine phosphatase non-receptor type 22 IEA
IBA
IMP
(PMID:21873635)
(PMID:23991106)
Ensembl
GO_Central
UniProtKB
PMID:21873635, PMID:23991106 GO_REF:0000107 NCBI chr 1:113,813,811...113,871,761
Ensembl chr 1:113,813,811...113,871,753
JBrowse link
G TNFAIP3 TNF alpha induced protein 3 IEA Ensembl GO_REF:0000107 NCBI chr 6:137,866,317...137,883,312
Ensembl chr 6:137,867,214...137,883,312
JBrowse link
positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSPA1A heat shock protein family A (Hsp70) member 1A IMP (PMID:24790089) UniProtKB PMID:24790089 NCBI chr 6:31,815,543...31,817,942
Ensembl chr 6:31,815,543...31,817,946
JBrowse link
G HSPA1B heat shock protein family A (Hsp70) member 1B IMP (PMID:24790089) UniProtKB PMID:24790089 NCBI chr 6:31,827,738...31,830,254
Ensembl chr 6:31,827,738...31,830,254
JBrowse link
G PELI3 pellino E3 ubiquitin protein ligase family member 3 ISO (MGI:MGI:5562512|PMID:23892723) MGI PMID:23892723 MGI:MGI:5562512 NCBI chr11:66,466,327...66,477,337
Ensembl chr11:66,466,327...66,477,337
JBrowse link
G SLC15A3 solute carrier family 15 member 3 ISS UniProt GO_REF:0000024 NCBI chr11:60,937,084...60,952,176
Ensembl chr11:60,937,084...60,952,530
JBrowse link
G SLC15A4 solute carrier family 15 member 4 ISS UniProt GO_REF:0000024 NCBI chr12:128,793,194...128,823,966
Ensembl chr12:128,793,194...128,823,958
JBrowse link
G TLR4 toll like receptor 4 IEA Ensembl GO_REF:0000107 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18670
    signaling 7210
      signal transduction 6573
        pattern recognition receptor signaling pathway 216
          cytoplasmic pattern recognition receptor signaling pathway 76
            nucleotide-binding oligomerization domain containing signaling pathway 42
              nucleotide-binding oligomerization domain containing 2 signaling pathway 17
                negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway 3
                positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway 6
                regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway + 9
Path 2
Term Annotations click to browse term
  biological_process 18670
    biological regulation 13308
      regulation of biological process 12640
        regulation of cellular process 12035
          signal transduction 6573
            intracellular receptor signaling pathway 299
              cytoplasmic pattern recognition receptor signaling pathway 76
                nucleotide-binding oligomerization domain containing signaling pathway 42
                  nucleotide-binding oligomerization domain containing 2 signaling pathway 17
                    negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway 3
                    positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway 6
                    regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway + 9
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.