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Term:elongin complex
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Accession:GO:0070449 term browser browse the term
Definition:A transcription elongation factor complex that suppresses RNA polymerase II pausing, and may act by promoting proper alignment of the 3'-end of nascent transcripts with the polymerase catalytic site. Consists of a transcriptionally active Elongin A subunit (abut 100 kDa)and two smaller Elongin B (about 18 kDa) and Elongin C (about 15 kDa)subunits.
Comment:See also the cellular component terms 'cyclin-dependent protein kinase activating kinase holoenzyme complex ; GO:0019907' and 'DNA-directed RNA polymerase II, holoenzyme ; GO:0016591'.
Synonyms:exact_synonym: elongin (SIII) complex;   transcription elongation factor SIII complex

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elongin complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07002622.1 RGD:1600115
G AABR07035541.3 RGD:13792537
G AABR07044940.1 RGD:13792537
G AABR07051791.1 RGD:13792537
G AABR07051982.1 RGD:13792537
G AABR07060156.1 RGD:13792537
G AABR07068955.1 RGD:13792537
G AC119015.2 RGD:1600115
G AC119015.3 RGD:1600115
G AC132539.1 RGD:1600115
G Eloa elongin A JBrowse link 5 154,348,167 154,363,324 RGD:1600115
G Elob elongin B JBrowse link 10 13,163,032 13,168,217 RGD:1624291
G Eloc elongin C JBrowse link 5 2,042,991 2,059,357 RGD:1624291
G Epop elongin BC and polycomb repressive complex 2 associated protein JBrowse link 10 85,573,369 85,574,889 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19737
    protein-containing complex 5748
      transcription elongation factor complex 65
        elongin complex 14
Path 2
Term Annotations click to browse term
  cellular_component 19737
    cellular anatomical entity 19353
      organelle 12456
        intracellular organelle 11935
          intracellular membrane-bounded organelle 9923
            nucleus 6746
              nuclear lumen 3990
                nucleoplasm 3363
                  transcription elongation factor complex 65
                    elongin complex 14
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.