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Term:interleukin-1-mediated signaling pathway
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Accession:GO:0070498 term browser browse the term
Definition:A series of molecular signals initiated by the binding of interleukin-1 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: IL-1-mediated signaling pathway;   interleukin-1-mediated signalling pathway
 narrow_synonym: IL-1 alpha-mediated signaling pathway;   IL-1 beta-mediated signaling pathway;   interleukin-1 alpha-mediated signaling pathway;   interleukin-1 beta-mediated signaling pathway


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interleukin-1-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G H BTRC beta-transducin repeat containing E3 ubiquitin protein ligase JBrowse link 10 101,353,808 101,557,321 RGD:2290271
G H CHUK component of inhibitor of nuclear factor kappa B kinase complex JBrowse link 10 100,188,298 100,229,610 RGD:2290271
G H CUL1 cullin 1 JBrowse link 7 148,697,756 148,801,110 RGD:2290271
G M Egr1 early growth response 1 RGD:9068941
G V EGR1 early growth response 1 JBrowse link 23 41,139,636 41,143,598 RGD:9068941
G P EGR1 early growth response 1 JBrowse link 2 140,440,829 140,445,302 RGD:14298760
G S Egr1 early growth response 1 JBrowse link NW_004936531 7,625,956 7,629,041 RGD:9068941
G D EGR1 early growth response 1 JBrowse link 11 26,046,195 26,049,806 RGD:13508589
G B EGR1 early growth response 1 JBrowse link 5 133,845,305 133,849,291 RGD:9068941
G C Egr1 early growth response 1 JBrowse link NW_004955418 2,001,509 2,005,269 RGD:9068941
G R Egr1 early growth response 1 JBrowse link 18 27,657,903 27,660,101 RGD:1624291
RGD:1600115
G M Egr1 early growth response 1 JBrowse link 18 34,861,207 34,864,956 RGD:2290270
G H EGR1 early growth response 1 JBrowse link 5 138,465,479 138,469,303 RGD:2290271
G H FBXW11 F-box and WD repeat domain containing 11 JBrowse link 5 171,861,549 172,006,638 RGD:2290271
G M Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta RGD:9068941
G V IKBKB inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 8 40,267,532 40,325,282 RGD:9068941
G P IKBKB inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 17 11,289,607 11,348,557 RGD:14298760
G S Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link NW_004936785 358,128 406,751 RGD:9068941
G D IKBKB inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 23,359,551 23,419,114 RGD:9068941
G B IKBKB inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 8 41,515,613 41,576,229 RGD:9068941
G C Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link NW_004955536 611,965 658,647 RGD:9068941
G R Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:1600115
RGD:1624291
G M Ikbkb inhibitor of kappaB kinase beta JBrowse link 8 22,659,205 22,706,589 RGD:2290270
G H IKBKB inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 8 42,270,727 42,332,460 RGD:2290271
G H IKBKG inhibitor of nuclear factor kappa B kinase regulatory subunit gamma JBrowse link X 154,541,238 154,565,046 RGD:2290271
G M Il1a interleukin 1 alpha RGD:9068941
G V IL1A interleukin 1 alpha JBrowse link 14 15,789,710 15,801,938 RGD:9068941
G P IL1A interleukin 1 alpha JBrowse link 3 43,718,320 43,731,668 RGD:9068941
G S Il1a interleukin 1 alpha JBrowse link NW_004936783 1,210,715 1,218,315 RGD:9068941
G D IL1A interleukin 1 alpha JBrowse link 17 36,969,581 36,979,445 RGD:9068941
G B IL1A interleukin 1 alpha JBrowse link 2A 89,273,482 89,284,421 RGD:9068941
G C Il1a interleukin 1 alpha JBrowse link NW_004955470 1,527,710 1,538,418 RGD:9068941
G R Il1a interleukin 1 alpha JBrowse link 3 121,824,712 121,836,122 RGD:1624291
G M Il1a interleukin 1 alpha JBrowse link 2 129,299,609 129,310,186 RGD:2290270
G H IL1A interleukin 1 alpha JBrowse link 2 112,773,925 112,784,493 RGD:2290271
G M Il1b interleukin 1 beta RGD:9068941
G V IL1B interleukin 1 beta JBrowse link 14 15,844,628 15,852,652 RGD:9068941
G S Il1b interleukin 1 beta JBrowse link NW_004936783 1,251,678 1,256,807 RGD:9068941
G D IL1B interleukin 1 beta JBrowse link 17 37,019,329 37,033,388 RGD:9068941
G B IL1B interleukin 1 beta JBrowse link 2A 89,216,313 89,223,358 RGD:9068941
G C Il1b interleukin 1 beta JBrowse link NW_004955470 1,486,936 1,491,888 RGD:9068941
G R Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:1624291
RGD:1600115
G M Il1b interleukin 1 beta JBrowse link 2 129,364,569 129,371,164 RGD:2290270
G H IL1B interleukin 1 beta JBrowse link 2 112,829,751 112,836,843 RGD:2290271
G M Il1r1 interleukin 1 receptor type 1 RGD:9068941
G V IL1R1 interleukin 1 receptor type 1 JBrowse link 14 5,781,486 5,852,872 RGD:9068941
G P IL1R1 interleukin 1 receptor type 1 JBrowse link 3 52,192,912 52,334,734 RGD:14298760
G S Il1r1 interleukin 1 receptor type 1 JBrowse link NW_004936713 808,761 881,070 RGD:9068941
G D IL1R1 interleukin 1 receptor type 1 JBrowse link 10 40,825,986 40,897,898 RGD:13508589
G B IL1R1 interleukin 1 receptor type 1 RGD:9068941
G C Il1r1 interleukin 1 receptor type 1 JBrowse link NW_004955470 7,685,498 7,703,374 RGD:9068941
G R Il1r1 interleukin 1 receptor type 1 JBrowse link 9 46,962,291 47,038,139 RGD:5130945
RGD:13792537
RGD:1624291
RGD:1600115
G M Il1r1 interleukin 1 receptor, type I JBrowse link 1 40,222,480 40,316,201 RGD:2290270
G H IL1R1 interleukin 1 receptor type 1 JBrowse link 2 102,069,638 102,179,874 RGD:2290271
G H IL1R2 interleukin 1 receptor type 2 JBrowse link 2 101,991,805 102,028,544 RGD:2290271
G H IL1RAP interleukin 1 receptor accessory protein JBrowse link 3 190,514,085 190,659,750 RGD:2290271
G P IL1RL2 interleukin 1 receptor like 2 JBrowse link 3 51,978,857 52,011,607 RGD:14298760
G H IL1RL2 interleukin 1 receptor like 2 JBrowse link 2 102,186,973 102,242,910 RGD:2290271
G H IL1RN interleukin 1 receptor antagonist JBrowse link 2 113,099,365 113,134,016 RGD:2290271
G M Irak1 interleukin 1 receptor associated kinase 1 RGD:9068941
G V IRAK1 interleukin 1 receptor associated kinase 1 JBrowse link X 128,433,462 128,443,126 RGD:9068941
G P IRAK1 interleukin 1 receptor associated kinase 1 JBrowse link X 124,717,604 124,724,855 RGD:14298760
RGD:9068941
G S Irak1 interleukin 1 receptor associated kinase 1 JBrowse link NW_004936809 891,407 900,311 RGD:9068941
G D IRAK1 interleukin 1 receptor associated kinase 1 JBrowse link X 121,853,340 121,862,582 RGD:13508589
RGD:9068941
G B IRAK1 interleukin 1 receptor associated kinase 1 JBrowse link X 143,560,802 143,570,185 RGD:9068941
G C Irak1 interleukin 1 receptor associated kinase 1 JBrowse link NW_004955580 663,651 668,622 RGD:9068941
G R Irak1 interleukin-1 receptor-associated kinase 1 JBrowse link X 156,716,469 156,726,367 RGD:1624291
RGD:13792537
G M Irak1 interleukin-1 receptor-associated kinase 1 JBrowse link X 74,013,914 74,023,921 RGD:2290270
RGD:9068941
G H IRAK1 interleukin 1 receptor associated kinase 1 JBrowse link X 154,010,507 154,019,984 RGD:2290271
G M Irak2 interleukin 1 receptor associated kinase 2 RGD:9068941
G V IRAK2 interleukin 1 receptor associated kinase 2 JBrowse link 22 46,204,600 46,279,863 RGD:9068941
G P IRAK2 interleukin 1 receptor associated kinase 2 JBrowse link 13 66,350,606 66,416,834 RGD:14298760
G S Irak2 interleukin 1 receptor associated kinase 2 JBrowse link NW_004936602 3,073,910 3,129,344 RGD:9068941
G D IRAK2 interleukin 1 receptor associated kinase 2 JBrowse link 20 8,133,987 8,197,009 RGD:13508589
G B IRAK2 interleukin 1 receptor associated kinase 2 JBrowse link 3 10,100,279 10,179,487 RGD:9068941
G C Irak2 interleukin 1 receptor associated kinase 2 JBrowse link NW_004955561 1,585,842 1,650,268 RGD:9068941
G R Irak2 interleukin-1 receptor-associated kinase 2 JBrowse link 4 145,594,575 145,651,066 RGD:1624291
RGD:13792537
G M Irak2 interleukin-1 receptor-associated kinase 2 JBrowse link 6 113,638,467 113,695,026 RGD:2290270
G H IRAK2 interleukin 1 receptor associated kinase 2 JBrowse link 3 10,164,919 10,243,745 RGD:2290271
G M Irak3 interleukin 1 receptor associated kinase 3 RGD:9068941
G V IRAK3 interleukin 1 receptor associated kinase 3 JBrowse link 11 61,868,817 61,920,896 RGD:9068941
G P IRAK3 interleukin 1 receptor associated kinase 3 JBrowse link 5 30,524,704 30,601,067 RGD:14298760
G S Irak3 interleukin 1 receptor associated kinase 3 JBrowse link NW_004936545 4,233,353 4,284,324 RGD:9068941
G D IRAK3 interleukin 1 receptor associated kinase 3 JBrowse link 10 8,683,541 8,730,757 RGD:13508589
G B IRAK3 interleukin 1 receptor associated kinase 3 JBrowse link 12 22,661,613 22,721,203 RGD:9068941
G C Irak3 interleukin 1 receptor associated kinase 3 JBrowse link NW_004955458 12,839,995 12,880,285 RGD:9068941
G R Irak3 interleukin-1 receptor-associated kinase 3 JBrowse link 7 64,922,830 64,982,224 RGD:1624291
RGD:13792537
G M Irak3 interleukin-1 receptor-associated kinase 3 JBrowse link 10 120,141,648 120,202,130 RGD:2290270
G H IRAK3 interleukin 1 receptor associated kinase 3 JBrowse link 12 66,189,214 66,254,622 RGD:2290271
G H IRAK4 interleukin 1 receptor associated kinase 4 JBrowse link 12 43,758,909 43,789,543 RGD:2290271
G B LOC100975471 suppression of tumorigenicity 18 protein JBrowse link 8 48,528,831 48,832,588 RGD:9068941
G P LOC110258578 interleukin-1 beta-like RGD:9068941
G H MAP3K3 mitogen-activated protein kinase kinase kinase 3 JBrowse link 17 63,622,209 63,696,305 RGD:2290271
G H MAP3K7 mitogen-activated protein kinase kinase kinase 7 JBrowse link 6 90,513,579 90,587,072 RGD:2290271
G H MAP3K8 mitogen-activated protein kinase kinase kinase 8 JBrowse link 10 30,434,021 30,461,833 RGD:2290271
G M Mapk3 mitogen-activated protein kinase 3 RGD:9068941
G V MAPK3 mitogen-activated protein kinase 3 JBrowse link 5 26,536,471 26,545,666 RGD:9068941
G P MAPK3 mitogen-activated protein kinase 3 JBrowse link 3 18,291,444 18,299,410 RGD:14298760
G S Mapk3 mitogen-activated protein kinase 3 JBrowse link NW_004936501 12,342,670 12,390,650 RGD:9068941
G D MAPK3 mitogen-activated protein kinase 3 JBrowse link 6 18,109,184 18,115,728 RGD:9068941
G B MAPK3 mitogen-activated protein kinase 3 RGD:9068941
G C Mapk3 mitogen-activated protein kinase 3 JBrowse link NW_004955493 6,870,699 6,876,836 RGD:9068941
G R Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:1624291
G M Mapk3 mitogen-activated protein kinase 3 JBrowse link 7 126,759,626 126,765,816 RGD:2290270
G H MAPK3 mitogen-activated protein kinase 3 JBrowse link 16 30,114,105 30,123,309 RGD:2290271
G M Myd88 MYD88 innate immune signal transduction adaptor RGD:9068941
G V MYD88 MYD88 innate immune signal transduction adaptor JBrowse link 15 1,276,804 1,281,811 RGD:9068941
G P MYD88 MYD88 innate immune signal transduction adaptor JBrowse link 13 22,976,951 22,979,568 RGD:9068941
G S Myd88 MYD88 innate immune signal transduction adaptor JBrowse link NW_004936473 27,672,237 27,676,339 RGD:9068941
G D MYD88 MYD88 innate immune signal transduction adaptor JBrowse link 23 7,901,578 7,905,274 RGD:9068941
G B MYD88 MYD88 innate immune signal transduction adaptor JBrowse link 3 38,036,565 38,041,014 RGD:9068941
G C Myd88 MYD88 innate immune signal transduction adaptor JBrowse link NW_004955427 25,553,589 25,557,654 RGD:9068941
G R Myd88 MYD88, innate immune signal transduction adaptor JBrowse link 8 128,022,512 128,027,462 RGD:1624291
G M Myd88 myeloid differentiation primary response gene 88 JBrowse link 9 119,335,934 119,340,018 RGD:2290270
G H MYD88 MYD88 innate immune signal transduction adaptor JBrowse link 3 38,138,661 38,143,022 RGD:2290271
G H NFKB1 nuclear factor kappa B subunit 1 JBrowse link 4 102,501,266 102,617,302 RGD:2290271
G H NFKBIA NFKB inhibitor alpha JBrowse link 14 35,401,513 35,404,749 RGD:2290271
G H NOD1 nucleotide binding oligomerization domain containing 1 JBrowse link 7 30,424,527 30,478,866 RGD:2290271
G H NOD2 nucleotide binding oligomerization domain containing 2 JBrowse link 16 50,693,587 50,733,077 RGD:2290271
G H PEDS1-UBE2V1 PEDS1-UBE2V1 readthrough JBrowse link 20 50,081,124 50,153,723 RGD:2290271
G H PELI1 pellino E3 ubiquitin protein ligase 1 JBrowse link 2 64,092,652 64,144,421 RGD:2290271
G H PELI2 pellino E3 ubiquitin protein ligase family member 2 JBrowse link 14 56,118,329 56,301,586 RGD:2290271
G H PELI3 pellino E3 ubiquitin protein ligase family member 3 JBrowse link 11 66,466,327 66,477,337 RGD:2290271
G M Plcb1 phospholipase C beta 1 RGD:9068941
G V PLCB1 phospholipase C beta 1 JBrowse link 2 29,242,601 29,994,238 RGD:9068941
G P PLCB1 phospholipase C beta 1 JBrowse link 17 17,007,197 17,745,314 RGD:14298760
G S Plcb1 phospholipase C beta 1 JBrowse link NW_004936485 10,548,966 11,254,139 RGD:9068941
G D PLCB1 phospholipase C beta 1 JBrowse link 24 13,337,285 13,996,218 RGD:9068941
G B PLCB1 phospholipase C beta 1 JBrowse link 20 8,106,665 8,858,572 RGD:9068941
G C Plcb1 phospholipase C beta 1 JBrowse link NW_004955415 18,210,608 18,915,099 RGD:9068941
G R Plcb1 phospholipase C beta 1 JBrowse link 3 127,721,244 128,419,565 RGD:1624291
RGD:1600115
G M Plcb1 phospholipase C, beta 1 JBrowse link 2 134,786,164 135,475,258 RGD:2290270
G H PLCB1 phospholipase C beta 1 JBrowse link 20 8,132,266 8,884,900 RGD:2290271
G H PSMA1 proteasome 20S subunit alpha 1 JBrowse link 11 14,504,876 14,643,634 RGD:2290271
G H PSMA2 proteasome 20S subunit alpha 2 JBrowse link 7 42,916,861 42,932,174 RGD:2290271
G H PSMA3 proteasome 20S subunit alpha 3 JBrowse link 14 58,244,805 58,272,009 RGD:2290271
G H PSMA4 proteasome 20S subunit alpha 4 JBrowse link 15 78,540,405 78,552,417 RGD:2290271
G H PSMA5 proteasome 20S subunit alpha 5 JBrowse link 1 109,399,042 109,426,448 RGD:2290271
G H PSMA6 proteasome 20S subunit alpha 6 JBrowse link 14 35,278,558 35,317,493 RGD:2290271
G H PSMA7 proteasome 20S subunit alpha 7 JBrowse link 20 62,136,733 62,143,394 RGD:2290271
G H PSMA8 proteasome 20S subunit alpha 8 JBrowse link 18 26,133,869 26,193,355 RGD:2290271
G H PSMB1 proteasome 20S subunit beta 1 JBrowse link 6 170,535,120 170,553,307 RGD:2290271
G H PSMB10 proteasome 20S subunit beta 10 JBrowse link 16 67,934,506 67,936,850 RGD:2290271
G H PSMB11 proteasome subunit beta 11 JBrowse link 14 23,042,212 23,044,060 RGD:2290271
G H PSMB2 proteasome 20S subunit beta 2 JBrowse link 1 35,599,541 35,641,526 RGD:2290271
G H PSMB3 proteasome 20S subunit beta 3 JBrowse link 17 38,752,741 38,764,225 RGD:2290271
G H PSMB4 proteasome 20S subunit beta 4 JBrowse link 1 151,399,573 151,401,937 RGD:2290271
G H PSMB5 proteasome 20S subunit beta 5 JBrowse link 14 23,025,851 23,035,220 RGD:2290271
G H PSMB6 proteasome 20S subunit beta 6 JBrowse link 17 4,796,144 4,798,503 RGD:2290271
G H PSMB7 proteasome 20S subunit beta 7 JBrowse link 9 124,353,465 124,415,442 RGD:2290271
G H PSMB8 proteasome 20S subunit beta 8 JBrowse link 6 32,840,717 32,844,679 RGD:2290271
G H PSMB9 proteasome 20S subunit beta 9 JBrowse link 6 32,854,192 32,859,851 RGD:2290271
G H PSMC1 proteasome 26S subunit, ATPase 1 JBrowse link 14 90,256,553 90,275,429 RGD:2290271
G H PSMC2 proteasome 26S subunit, ATPase 2 JBrowse link 7 103,344,405 103,369,395 RGD:2290271
G H PSMC3 proteasome 26S subunit, ATPase 3 JBrowse link 11 47,418,769 47,426,473 RGD:2290271
G H PSMC4 proteasome 26S subunit, ATPase 4 JBrowse link 19 39,971,005 39,981,764 RGD:2290271
G H PSMC5 proteasome 26S subunit, ATPase 5 JBrowse link 17 63,827,431 63,832,027 RGD:2290271
G H PSMC6 proteasome 26S subunit, ATPase 6 JBrowse link 14 52,707,163 52,728,590 RGD:2290271
G H PSMD1 proteasome 26S subunit, non-ATPase 1 JBrowse link 2 231,056,864 231,172,827 RGD:2290271
G H PSMD10 proteasome 26S subunit, non-ATPase 10 JBrowse link X 108,084,205 108,091,644 RGD:2290271
G H PSMD11 proteasome 26S subunit, non-ATPase 11 JBrowse link 17 32,444,510 32,483,319 RGD:2290271
G H PSMD12 proteasome 26S subunit, non-ATPase 12 JBrowse link 17 67,337,916 67,366,598 RGD:2290271
G H PSMD13 proteasome 26S subunit, non-ATPase 13 JBrowse link 11 236,972 252,984 RGD:2290271
G H PSMD14 proteasome 26S subunit, non-ATPase 14 JBrowse link 2 161,308,425 161,411,717 RGD:2290271
G H PSMD2 proteasome 26S subunit, non-ATPase 2 JBrowse link 3 184,299,241 184,309,050 RGD:2290271
G H PSMD3 proteasome 26S subunit, non-ATPase 3 JBrowse link 17 39,980,807 39,997,959 RGD:2290271
G H PSMD4 proteasome 26S subunit, non-ATPase 4 JBrowse link 1 151,254,734 151,267,479 RGD:2290271
G H PSMD5 proteasome 26S subunit, non-ATPase 5 JBrowse link 9 120,816,053 120,842,922 RGD:2290271
G H PSMD6 proteasome 26S subunit, non-ATPase 6 JBrowse link 3 64,010,549 64,024,010 RGD:2290271
G H PSMD7 proteasome 26S subunit, non-ATPase 7 JBrowse link 16 74,296,814 74,306,288 RGD:2290271
G H PSMD8 proteasome 26S subunit, non-ATPase 8 JBrowse link 19 38,374,550 38,383,824 RGD:2290271
G H PSMD9 proteasome 26S subunit, non-ATPase 9 JBrowse link 12 121,888,790 121,918,297 RGD:2290271
G H PSME1 proteasome activator subunit 1 JBrowse link 14 24,136,158 24,138,967 RGD:2290271
G H PSME2 proteasome activator subunit 2 JBrowse link 14 24,143,365 24,146,646 RGD:2290271
G H PSME3 proteasome activator subunit 3 JBrowse link 17 42,833,397 42,843,760 RGD:2290271
G H PSME4 proteasome activator subunit 4 JBrowse link 2 53,864,069 53,970,993 RGD:2290271
G H PSMF1 proteasome inhibitor subunit 1 JBrowse link 20 1,113,229 1,172,246 RGD:2290271
G H RBX1 ring-box 1 JBrowse link 22 40,951,378 40,973,309 RGD:2290271
G M Rela RELA proto-oncogene, NF-kB subunit RGD:9068941
G V RELA RELA proto-oncogene, NF-kB subunit JBrowse link 1 8,576,059 8,585,561 RGD:9068941
G P RELA RELA proto-oncogene, NF-kB subunit JBrowse link 2 6,594,869 6,602,684 RGD:14298760
G S Rela RELA proto-oncogene, NF-kB subunit JBrowse link NW_004936599 3,800,142 3,810,583 RGD:9068941
G D RELA RELA proto-oncogene, NF-kB subunit JBrowse link 18 51,550,003 51,558,861 RGD:13508589
G B RELA RELA proto-oncogene, NF-kB subunit JBrowse link 11 61,012,839 61,022,225 RGD:9068941
G C Rela RELA proto-oncogene, NF-kB subunit JBrowse link NW_004955422 19,602,930 19,612,263 RGD:9068941
G R Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:1624291
G M Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) JBrowse link 19 5,637,442 5,648,134 RGD:2290270
G H RELA RELA proto-oncogene, NF-kB subunit JBrowse link 11 65,653,596 65,662,972 RGD:2290271
G H RIPK2 receptor interacting serine/threonine kinase 2 JBrowse link 8 89,757,816 89,791,064 RGD:2290271
G H RPS27A ribosomal protein S27a JBrowse link 2 55,231,903 55,235,853 RGD:2290271
G M Rps6ka4 ribosomal protein S6 kinase A4 RGD:9068941
G V RPS6KA4 ribosomal protein S6 kinase A4 JBrowse link 1 9,860,403 9,874,440 RGD:9068941
G P RPS6KA4 ribosomal protein S6 kinase A4 JBrowse link 2 7,751,965 7,765,301 RGD:14298760
G S Rps6ka4 ribosomal protein S6 kinase A4 JBrowse link NW_004936599 4,855,952 4,866,417 RGD:9068941
G D RPS6KA4 ribosomal protein S6 kinase A4 JBrowse link 18 52,708,849 52,720,561 RGD:13508589
G B RPS6KA4 ribosomal protein S6 kinase A4 JBrowse link 11 59,715,699 59,728,782 RGD:9068941
G C Rps6ka4 ribosomal protein S6 kinase A4 JBrowse link NW_004955422 20,726,286 20,736,841 RGD:9068941
G R Rps6ka4 ribosomal protein S6 kinase A4 JBrowse link 1 222,087,328 222,098,284 RGD:1624291
G M Rps6ka4 ribosomal protein S6 kinase, polypeptide 4 JBrowse link 19 6,829,084 6,842,145 RGD:2290270
G H RPS6KA4 ribosomal protein S6 kinase A4 JBrowse link 11 64,359,162 64,372,215 RGD:2290271
G M Rps6ka5 ribosomal protein S6 kinase A5 RGD:9068941
G V RPS6KA5 ribosomal protein S6 kinase A5 JBrowse link 24 68,620,637 68,821,996 RGD:9068941
G P RPS6KA5 ribosomal protein S6 kinase A5 JBrowse link 7 112,561,985 112,753,666 RGD:14298760
G S Rps6ka5 ribosomal protein S6 kinase A5 JBrowse link NW_004936488 17,937,421 18,132,845 RGD:9068941
G D RPS6KA5 ribosomal protein S6 kinase A5 JBrowse link 8 61,801,185 61,962,846 RGD:13508589
G B RPS6KA5 ribosomal protein S6 kinase A5 JBrowse link 14 71,489,654 71,679,250 RGD:9068941
G C Rps6ka5 ribosomal protein S6 kinase A5 JBrowse link NW_004955438 13,218,451 13,392,080 RGD:9068941
G R Rps6ka5 ribosomal protein S6 kinase A5 JBrowse link 6 124,557,892 124,735,787 RGD:1624291
G M Rps6ka5 ribosomal protein S6 kinase, polypeptide 5 JBrowse link 12 100,548,439 100,725,328 RGD:2290270
G H RPS6KA5 ribosomal protein S6 kinase A5 JBrowse link 14 90,847,861 91,060,649 RGD:2290271
G H SEM1 SEM1 26S proteasome complex subunit JBrowse link 7 96,481,626 96,709,891 RGD:2290271
G H SKP1 S-phase kinase associated protein 1 JBrowse link 5 134,148,935 134,177,033 RGD:2290271
G H SQSTM1 sequestosome 1 JBrowse link 5 179,806,393 179,838,078 RGD:2290271
G M St18 ST18 C2H2C-type zinc finger transcription factor RGD:9068941
G V ST18 ST18 C2H2C-type zinc finger transcription factor JBrowse link 8 48,214,764 48,521,428 RGD:9068941
G P ST18 ST18 C2H2C-type zinc finger transcription factor JBrowse link 4 77,707,143 78,002,016 RGD:14298760
G S St18 ST18 C2H2C-type zinc finger transcription factor JBrowse link NW_004936590 737,086 798,433 RGD:9068941
G D ST18 ST18 C2H2C-type zinc finger transcription factor JBrowse link 29 3,971,851 4,266,642 RGD:13508589
G C St18 ST18 C2H2C-type zinc finger transcription factor JBrowse link NW_004955454 11,715,538 12,016,396 RGD:9068941
G R St18 ST18 C2H2C-type zinc finger transcription factor JBrowse link 5 12,437,617 12,787,223 RGD:1600115
RGD:1624291
G M St18 suppression of tumorigenicity 18 JBrowse link 1 6,487,231 6,860,940 RGD:2290270
G H ST18 ST18 C2H2C-type zinc finger transcription factor JBrowse link 8 52,110,832 52,409,879 RGD:2290271
G H TAB1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 JBrowse link 22 39,399,780 39,437,132 RGD:2290271
G H TAB2 TGF-beta activated kinase 1 (MAP3K7) binding protein 2 JBrowse link 6 149,217,924 149,411,613 RGD:2290271
G H TAB3 TGF-beta activated kinase 1 (MAP3K7) binding protein 3 JBrowse link X 30,827,442 30,889,391 RGD:2290271
G M Tirap TIR domain containing adaptor protein RGD:9068941
G V TIRAP TIR domain containing adaptor protein JBrowse link 1 117,417,561 117,419,870 RGD:9068941
G P TIRAP TIR domain containing adaptor protein JBrowse link 9 53,374,559 53,394,172 RGD:9068941
G S Tirap TIR domain containing adaptor protein JBrowse link NW_004936572 5,926,193 5,938,621 RGD:9068941
G D TIRAP TIR domain containing adaptor protein JBrowse link 5 8,222,217 8,237,595 RGD:9068941
G B TIRAP TIR domain containing adaptor protein JBrowse link 11 121,100,558 121,112,844 RGD:9068941
G C Tirap TIR domain containing adaptor protein JBrowse link NW_004955412 27,303,548 27,315,031 RGD:9068941
G R Tirap TIR domain containing adaptor protein JBrowse link 8 36,382,029 36,399,625 RGD:1624291
G M Tirap toll-interleukin 1 receptor (TIR) domain-containing adaptor protein JBrowse link 9 35,184,391 35,200,291 RGD:2290270
G H TIRAP TIR domain containing adaptor protein JBrowse link 11 126,283,087 126,294,933 RGD:9068941
G M Tnip2 TNFAIP3 interacting protein 2 RGD:9068941
G V TNIP2 TNFAIP3 interacting protein 2 JBrowse link 27 46,001,814 46,017,676 RGD:9068941
G P TNIP2 TNFAIP3 interacting protein 2 JBrowse link 8 1,530,534 1,554,677 RGD:14298760
G S Tnip2 TNFAIP3 interacting protein 2 JBrowse link NW_004936477 20,810,188 20,841,537 RGD:9068941
G D TNIP2 TNFAIP3 interacting protein 2 JBrowse link 3 61,511,676 61,535,480 RGD:9068941
G B TNIP2 TNFAIP3 interacting protein 2 JBrowse link 4 2,884,265 2,899,160 RGD:9068941
G C Tnip2 TNFAIP3 interacting protein 2 JBrowse link NW_004955514 1,682,641 1,687,881 RGD:9068941
G R Tnip2 TNFAIP3 interacting protein 2 JBrowse link 14 81,487,934 81,505,889 RGD:1624291
G M Tnip2 TNFAIP3 interacting protein 2 JBrowse link 5 34,496,096 34,513,979 RGD:2290270
G H TNIP2 TNFAIP3 interacting protein 2 JBrowse link 4 2,741,648 2,756,336 RGD:2290271
G M Tollip toll interacting protein RGD:9068941
G V TOLLIP toll interacting protein JBrowse link 1 1,094,535 1,127,342 RGD:9068941
G P TOLLIP toll interacting protein JBrowse link 2 852,198 864,337 RGD:9068941
G S Tollip toll interacting protein JBrowse link NW_004936816 216,542 245,545 RGD:9068941
G D TOLLIP toll interacting protein JBrowse link 18 45,559,385 45,578,467 RGD:9068941
G C Tollip toll interacting protein JBrowse link NW_004955476 10,987,223 11,009,134 RGD:9068941
G R Tollip toll interacting protein JBrowse link 1 214,823,993 214,844,861 RGD:1624291
G M Tollip toll interacting protein JBrowse link 7 141,881,580 141,902,461 RGD:2290270
G H TOLLIP toll interacting protein JBrowse link 11 1,274,368 1,309,632 RGD:2290271
G M Traf6 TNF receptor associated factor 6 RGD:9068941
G V TRAF6 TNF receptor associated factor 6 JBrowse link 1 28,726,357 28,752,389 RGD:9068941
G P TRAF6 TNF receptor associated factor 6 JBrowse link 2 24,602,749 24,628,263 RGD:14298760
G S Traf6 TNF receptor associated factor 6 JBrowse link NW_004936533 1,857,685 1,874,973 RGD:9068941
G D TRAF6 TNF receptor associated factor 6 JBrowse link 18 31,674,242 31,689,160 RGD:13508589
G B TRAF6 TNF receptor associated factor 6 JBrowse link 11 36,457,633 36,483,616 RGD:9068941
G C Traf6 TNF receptor associated factor 6 JBrowse link NW_004955422 9,925,765 9,950,354 RGD:9068941
G R Traf6 TNF receptor associated factor 6 JBrowse link 3 91,252,829 91,271,607 RGD:5130945
RGD:13792537
RGD:1624291
G M Traf6 TNF receptor-associated factor 6 JBrowse link 2 101,678,420 101,701,668 RGD:2290270
G H TRAF6 TNF receptor associated factor 6 JBrowse link 11 36,483,769 36,510,313 RGD:2290271
G H UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 JBrowse link 19 18,563,766 18,577,550 RGD:2290271
G H UBB ubiquitin B JBrowse link 17 16,380,793 16,382,745 RGD:2290271
G H UBC ubiquitin C JBrowse link 12 124,911,646 124,914,650 RGD:2290271
G H UBE2N ubiquitin conjugating enzyme E2 N JBrowse link 12 93,405,684 93,442,336 RGD:2290271
G H UBE2V1 ubiquitin conjugating enzyme E2 V1 JBrowse link 20 50,081,124 50,115,957 RGD:2290271
negative regulation of interleukin-1-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G M Il1r2 interleukin 1 receptor type 2 RGD:9068941
G V IL1R2 interleukin 1 receptor type 2 JBrowse link 14 5,672,434 5,708,270 RGD:9068941
G P IL1R2 interleukin 1 receptor type 2 JBrowse link 3 52,367,434 52,406,393 RGD:14298760
G S Il1r2 interleukin 1 receptor type 2 JBrowse link NW_004936713 679,680 716,801 RGD:9068941
G D IL1R2 interleukin 1 receptor type 2 JBrowse link 10 40,967,532 41,003,659 RGD:9068941
G B IL1R2 interleukin 1 receptor type 2 RGD:9068941
G C Il1r2 interleukin 1 receptor type 2 JBrowse link NW_004955470 7,518,565 7,562,219 RGD:9068941
G R Il1r2 interleukin 1 receptor type 2 JBrowse link 9 46,840,646 46,881,241 RGD:1624291
RGD:1600115
G M Il1r2 interleukin 1 receptor, type II JBrowse link 1 40,084,692 40,125,230 RGD:2290270
G H IL1R2 interleukin 1 receptor type 2 JBrowse link 2 101,991,805 102,028,544 RGD:2290271
G M Il1rn interleukin 1 receptor antagonist RGD:9068941
G V IL1RN interleukin 1 receptor antagonist JBrowse link 14 16,136,667 16,152,451 RGD:9068941
G P IL1RN interleukin 1 receptor antagonist RGD:14298760
G S Il1rn interleukin 1 receptor antagonist JBrowse link NW_004936783 1,447,158 1,466,331 RGD:9068941
G D IL1RN interleukin 1 receptor antagonist JBrowse link 17 37,236,690 37,250,424 RGD:13508589
G C Il1rn interleukin 1 receptor antagonist JBrowse link NW_004955470 1,145,022 1,159,413 RGD:9068941
G R Il1rn interleukin 1 receptor antagonist JBrowse link 3 1,449,778 1,468,624 RGD:1600115
RGD:13792537
RGD:1624291
G M Il1rn interleukin 1 receptor antagonist JBrowse link 2 24,336,860 24,351,491 RGD:2290270
G H IL1RN interleukin 1 receptor antagonist JBrowse link 2 113,099,365 113,134,016 RGD:2290271
G M Il6 interleukin 6 RGD:9068941
G V IL6 interleukin 6 JBrowse link 21 35,577,513 35,582,385 RGD:9068941
G P IL6 interleukin 6 JBrowse link 9 91,506,421 91,510,830 RGD:9068941
G D IL6 interleukin 6 JBrowse link 14 36,474,268 36,478,519 RGD:9068941
G B IL6 interleukin 6 JBrowse link 7 23,415,922 23,420,767 RGD:9068941
G C Il6 interleukin 6 JBrowse link NW_004955410 25,079,835 25,084,390 RGD:9068941
G R Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:1624291
G M Il6 interleukin 6 JBrowse link 5 30,013,114 30,019,975 RGD:2290270
G H IL6 interleukin 6 JBrowse link 7 22,725,889 22,732,002 RGD:2290271
G B LOC100991079 interleukin-1 receptor antagonist protein JBrowse link 2A 88,991,646 89,008,013 RGD:9068941
G M Otud4 OTU deubiquitinase 4 RGD:9068941
G V OTUD4 OTU deubiquitinase 4 JBrowse link 7 91,709,184 91,756,437 RGD:9068941
G P OTUD4 OTU deubiquitinase 4 JBrowse link 8 83,240,759 83,288,237 RGD:14298760
G S Otud4 OTU deubiquitinase 4 JBrowse link NW_004936535 3,911,904 3,950,675 RGD:9068941
G D OTUD4 OTU deubiquitinase 4 JBrowse link 15 43,816,656 43,861,813 RGD:13508589
G B OTUD4 OTU deubiquitinase 4 JBrowse link 4 137,480,809 137,527,651 RGD:9068941
G C Otud4 OTU deubiquitinase 4 JBrowse link NW_004955428 1,062,998 1,108,711 RGD:9068941
G R Otud4 OTU deubiquitinase 4 JBrowse link 19 31,895,753 31,942,509 RGD:1624291
RGD:13792537
G M Otud4 OTU domain containing 4 JBrowse link 8 79,639,676 79,677,755 RGD:2290270
G H OTUD4 OTU deubiquitinase 4 JBrowse link 4 145,133,650 145,180,589 RGD:2290271
G V ZNF675 zinc finger protein 675 JBrowse link 6 21,193,513 21,219,564 RGD:9068941
G H ZNF675 zinc finger protein 675 JBrowse link 19 23,652,801 23,687,212 RGD:2290271
positive regulation of interleukin-1-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G M Il1r1 interleukin 1 receptor type 1 RGD:9068941
G V IL1R1 interleukin 1 receptor type 1 JBrowse link 14 5,781,486 5,852,872 RGD:9068941
G P IL1R1 interleukin 1 receptor type 1 JBrowse link 3 52,192,912 52,334,734 RGD:14298760
G S Il1r1 interleukin 1 receptor type 1 JBrowse link NW_004936713 808,761 881,070 RGD:9068941
G D IL1R1 interleukin 1 receptor type 1 JBrowse link 10 40,825,986 40,897,898 RGD:9068941
G B IL1R1 interleukin 1 receptor type 1 RGD:9068941
G C Il1r1 interleukin 1 receptor type 1 JBrowse link NW_004955470 7,685,498 7,703,374 RGD:9068941
G R Il1r1 interleukin 1 receptor type 1 JBrowse link 9 46,962,291 47,038,139 RGD:1624291
RGD:1600115
G M Il1r1 interleukin 1 receptor, type I JBrowse link 1 40,222,480 40,316,201 RGD:2290270
G H IL1R1 interleukin 1 receptor type 1 JBrowse link 2 102,069,638 102,179,874 RGD:2290271
regulation of interleukin-1-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G M Vrk2 VRK serine/threonine kinase 2 RGD:9068941
G V VRK2 VRK serine/threonine kinase 2 JBrowse link 14 48,803,149 48,909,144 RGD:9068941
G P VRK2 VRK serine/threonine kinase 2 JBrowse link 3 83,435,250 83,537,022 RGD:14298760
G S Vrk2 VRK serine/threonine kinase 2 JBrowse link NW_004936491 3,956,171 4,057,753 RGD:9068941
G D VRK2 VRK serine/threonine kinase 2 JBrowse link 10 58,432,144 58,544,189 RGD:13508589
G B VRK2 VRK serine/threonine kinase 2 JBrowse link 2A 58,158,347 58,271,245 RGD:9068941
G C Vrk2 VRK serine/threonine kinase 2 JBrowse link NW_004955424 25,307,221 25,397,900 RGD:9068941
G R Vrk2 VRK serine/threonine kinase 2 JBrowse link 14 110,739,835 110,883,836 RGD:1624291
G M Vrk2 vaccinia related kinase 2 JBrowse link 11 26,471,398 26,594,012 RGD:2290270
G H VRK2 VRK serine/threonine kinase 2 JBrowse link 2 57,907,651 58,163,993 RGD:2290271
G M Zbp1 Z-DNA binding protein 1 RGD:9068941
G V ZBP1 Z-DNA binding protein 1 JBrowse link 2 6,494,410 6,510,928 RGD:9068941
G P ZBP1 Z-DNA binding protein 1 JBrowse link 17 57,975,982 57,986,117 RGD:9068941
G S Zbp1 Z-DNA binding protein 1 JBrowse link NW_004936530 398,980 408,798 RGD:9068941
G D ZBP1 Z-DNA binding protein 1 JBrowse link 24 42,583,674 42,589,857 RGD:9068941
G B ZBP1 Z-DNA binding protein 1 JBrowse link 20 53,944,224 53,961,362 RGD:9068941
G C Zbp1 Z-DNA binding protein 1 JBrowse link NW_004955445 1,867,436 1,878,132 RGD:9068941
G R Zbp1 Z-DNA binding protein 1 JBrowse link 3 171,276,062 171,292,062 RGD:1600115
RGD:1624291
G M Zbp1 Z-DNA binding protein 1 JBrowse link 2 173,206,612 173,218,959 RGD:2290270
G H ZBP1 Z-DNA binding protein 1 JBrowse link 20 57,603,852 57,620,480 RGD:2290271

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 130409
    signaling 46554
      signal transduction 42147
        cell surface receptor signaling pathway 19962
          cytokine-mediated signaling pathway 3168
            interleukin-1-mediated signaling pathway 277
              negative regulation of interleukin-1-mediated signaling pathway 32
              positive regulation of interleukin-1-mediated signaling pathway 8
              regulation of interleukin-1-mediated signaling pathway + 56
Path 2
Term Annotations click to browse term
  biological_process 130409
    response to stimulus 67670
      response to chemical 39034
        response to organic substance 28072
          cellular response to organic substance 21012
            cellular response to cytokine stimulus 7501
              cytokine-mediated signaling pathway 3168
                interleukin-1-mediated signaling pathway 277
                  negative regulation of interleukin-1-mediated signaling pathway 32
                  positive regulation of interleukin-1-mediated signaling pathway 8
                  regulation of interleukin-1-mediated signaling pathway + 56
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.