Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:interleukin-1-mediated signaling pathway
go back to main search page
Accession:GO:0070498 term browser browse the term
Definition:A series of molecular signals initiated by the binding of interleukin-1 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: IL-1-mediated signaling pathway;   interleukin-1-mediated signalling pathway
 narrow_synonym: IL-1 alpha-mediated signaling pathway;   IL-1 beta-mediated signaling pathway;   interleukin-1 alpha-mediated signaling pathway;   interleukin-1 beta-mediated signaling pathway


show annotations for term's descendants           Sort by:
 
interleukin-1-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egr1 early growth response 1 ISO
IEA
(PMID:20018936)
GO_REF:0000107
RGD
Ensembl
PMID:20018936 GO_REF:0000107 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta IEA
ISO
GO_REF:0000107
(PMID:25816133)
Ensembl
RGD
PMID:25816133 GO_REF:0000107 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Il1a interleukin 1 alpha ISO (MGI:5468848|PMID:23395675) RGD PMID:23395675 MGI:5468848 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta ISO
IEA
(PMID:25327529)
GO_REF:0000107
RGD
Ensembl
PMID:25327529 GO_REF:0000107 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1r1 interleukin 1 receptor type 1 IMP
ISO
IEA
IBA
(MGI:1889886|PMID:10854325)
GO_REF:0000107
PMID:21873635
GO_REF:0000108
(PMID:10383454)
RGD
Ensembl
GOC
PMID:10383454, PMID:10854325, PMID:20967881, PMID:21873635 GO_REF:0000107, GO_REF:0000108, MGI:1889886, RGD:5130945, RGD:13792537 NCBI chr 9:46,962,291...47,038,139
Ensembl chr 9:46,962,288...47,036,670
JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 NOT ISO
IBA
(PMID:10383454)
(MGI:1889886|PMID:10854325), (MGI:2181508|PMID:12054681)
(PMID:11397809)
PMID:21873635
RGD PMID:10383454, PMID:10854325, PMID:11397809, PMID:12054681, PMID:21873635 MGI:1889886, MGI:2181508, RGD:13792537 NCBI chr  X:156,716,469...156,726,367
Ensembl chr  X:156,716,604...156,725,977
JBrowse link
G Irak2 interleukin-1 receptor-associated kinase 2 ISO
IBA
(PMID:10383454)
PMID:21873635
RGD PMID:10383454, PMID:21873635 RGD:13792537 NCBI chr 4:145,594,575...145,651,066
Ensembl chr 4:145,594,575...145,651,053
JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 ISO
IBA
(PMID:10383454)
(MGI:2181508|PMID:12054681)
PMID:21873635
RGD PMID:10383454, PMID:12054681, PMID:21873635 MGI:2181508, RGD:13792537 NCBI chr 7:64,922,830...64,982,224
Ensembl chr 7:64,923,615...64,982,281
JBrowse link
G Mapk3 mitogen activated protein kinase 3 ISO (PMID:20018936) RGD PMID:20018936 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor ISO (MGI:1889886|PMID:10854325) RGD PMID:10854325 MGI:1889886 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841
JBrowse link
G Plcb1 phospholipase C beta 1 ISO
IEA
(PMID:8872139)
GO_REF:0000107
RGD
Ensembl
PMID:8872139 GO_REF:0000107 NCBI chr 3:127,721,244...128,419,565
Ensembl chr 3:128,155,069...128,419,545
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO UniProtKB:P01584 (PMID:25327529) RGD PMID:25327529 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rps6ka4 ribosomal protein S6 kinase A4 ISO (PMID:20018936) RGD PMID:20018936 NCBI chr 1:222,087,328...222,098,284
Ensembl chr 1:222,087,326...222,098,297
JBrowse link
G Rps6ka5 ribosomal protein S6 kinase A5 ISO (PMID:20018936) RGD PMID:20018936 NCBI chr 6:124,557,892...124,735,787
Ensembl chr 6:124,557,913...124,735,778
JBrowse link
G St18 ST18 C2H2C-type zinc finger transcription factor IEA
ISO
GO_REF:0000107
(PMID:18676404)
Ensembl
RGD
PMID:18676404 GO_REF:0000107 NCBI chr 5:12,437,617...12,787,223
Ensembl chr 5:12,437,525...12,563,429
JBrowse link
G Tirap TIR domain containing adaptor protein NOT ISO (MGI:2149909|PMID:11544529) RGD PMID:11544529 MGI:2149909 NCBI chr 8:36,382,029...36,399,625
Ensembl chr 8:36,385,353...36,388,224
JBrowse link
G Tnip2 TNFAIP3 interacting protein 2 ISO (MGI:3656197|PMID:16633345) RGD PMID:16633345 MGI:3656197 NCBI chr14:81,487,934...81,505,889
Ensembl chr14:81,488,008...81,504,686
JBrowse link
G Tollip toll interacting protein ISO (MGI:1889886|PMID:10854325) RGD PMID:10854325 MGI:1889886 NCBI chr 1:214,823,993...214,844,861
Ensembl chr 1:214,823,978...214,844,858
JBrowse link
G Traf6 TNF receptor associated factor 6 IMP
ISO
IBA
(MGI:2181820|PMID:10421844)
PMID:21873635
RGD PMID:10421844, PMID:20967881, PMID:21873635 MGI:2181820, RGD:5130945, RGD:13792537 NCBI chr 3:91,252,829...91,271,607
Ensembl chr 3:91,252,829...91,271,607
JBrowse link
negative regulation of interleukin-1-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1r2 interleukin 1 receptor type 2 IEA
ISO
GO_REF:0000107
PR:000045525 (MGI:5468848|PMID:23395675)
Ensembl
RGD
PMID:23395675 GO_REF:0000107, MGI:5468848 NCBI chr 9:46,840,646...46,881,241
Ensembl chr 9:46,840,992...46,881,264
JBrowse link
G Il1rn interleukin 1 receptor antagonist IEA
IBA
ISO
GO_REF:0000107
PMID:21873635
(PMID:2137200), (PMID:2139180)
Ensembl
RGD
PMID:2137200, PMID:2139180, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il6 interleukin 6 ISO (MGI:5795829|PMID:11159963) RGD PMID:11159963 MGI:5795829 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Otud4 OTU deubiquitinase 4 ISO
IBA
(PMID:29395066)
(MGI:6120140|PMID:29395066)
PMID:21873635
RGD PMID:29395066, PMID:21873635 MGI:6120140, RGD:13792537 NCBI chr19:31,895,753...31,942,509
Ensembl chr19:31,899,087...31,942,180
JBrowse link
positive regulation of interleukin-1-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1r1 interleukin 1 receptor type 1 IEA
ISO
GO_REF:0000107
PR:000045524 (MGI:5468848|PMID:23395675)
Ensembl
RGD
PMID:23395675 GO_REF:0000107, MGI:5468848 NCBI chr 9:46,962,291...47,038,139
Ensembl chr 9:46,962,288...47,036,670
JBrowse link
regulation of interleukin-1-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vrk2 VRK serine/threonine kinase 2 ISO (PMID:18286207) RGD PMID:18286207 NCBI chr14:110,739,835...110,883,836
Ensembl chr14:110,739,226...110,883,803
JBrowse link
G Zbp1 Z-DNA binding protein 1 ISS
ISO
GO_REF:0000024
(MGI:6394181|PMID:31630209)
UniProt
RGD
PMID:31630209 GO_REF:0000024, MGI:6394181 NCBI chr 3:171,276,062...171,292,062
Ensembl chr 3:171,276,062...171,286,537
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    signaling 7579
      signal transduction 7010
        cell surface receptor signaling pathway 2761
          cytokine-mediated signaling pathway 406
            interleukin-1-mediated signaling pathway 25
              negative regulation of interleukin-1-mediated signaling pathway 4
              positive regulation of interleukin-1-mediated signaling pathway 1
              regulation of interleukin-1-mediated signaling pathway + 7
Path 2
Term Annotations click to browse term
  biological_process 20020
    response to stimulus 10580
      response to chemical 6337
        response to organic substance 3864
          cellular response to organic substance 2844
            cellular response to cytokine stimulus 998
              cytokine-mediated signaling pathway 406
                interleukin-1-mediated signaling pathway 25
                  negative regulation of interleukin-1-mediated signaling pathway 4
                  positive regulation of interleukin-1-mediated signaling pathway 1
                  regulation of interleukin-1-mediated signaling pathway + 7
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.