Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:protein K63-linked ubiquitination
go back to main search page
Accession:GO:0070534 term browser browse the term
Definition:A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair.
Synonyms:exact_synonym: protein K63-linked polyubiquitination


show annotations for term's descendants           Sort by:
 
protein K63-linked ubiquitination term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07067339.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 9:40,817,654...40,818,097 JBrowse link
G Arih2 ariadne RBR E3 ubiquitin protein ligase 2 ISO (PMID:19340006) RGD PMID:19340006 NCBI chr 8:117,387,004...117,446,085
Ensembl chr 8:117,387,010...117,446,019
JBrowse link
G Bfar bifunctional apoptosis regulator ISO (PMID:21068390) RGD PMID:21068390 NCBI chr10:1,464,658...1,471,152
NCBI chr10:1,464,783...1,497,653
Ensembl chr10:1,464,765...1,497,653
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A ISS
ISO
GO_REF:0000024
(PMID:18305112)
UniProt
RGD
PMID:18305112 GO_REF:0000024 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Hectd1 HECT domain E3 ubiquitin protein ligase 1 ISO
IBA
MGI:MGI:2137552|MGI:MGI:3706565 (MGI:MGI:5427282|PMID:22431752)
PMID:21873635
RGD PMID:22431752, PMID:21873635 MGI:MGI:5427282, RGD:13792537 NCBI chr 6:72,509,658...72,596,285
Ensembl chr 6:72,510,255...72,596,446
JBrowse link
G Itch itchy E3 ubiquitin protein ligase ISO
IBA
(PMID:18718448), (PMID:19592251)
PMID:21873635
RGD PMID:18718448, PMID:19592251, PMID:21873635 RGD:13792537 NCBI chr 3:150,660,665...150,752,016
Ensembl chr 3:150,686,638...150,749,827
JBrowse link
G LOC100912618 ubiquitin-conjugating enzyme E2 variant 1-like IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:5,867,350...5,869,085
Ensembl chr 3:164,343,833...164,366,684
JBrowse link
G LOC679539 similar to ubiquitin-conjugating enzyme E2 variant 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:5,837,634...5,839,362
Ensembl chr 3:164,343,833...164,366,684
JBrowse link
G Magel2 MAGE family member L2 ISO (PMID:23452853) RGD PMID:23452853 NCBI chr 1:123,015,404...123,019,945
Ensembl chr 1:123,015,746...123,019,522
JBrowse link
G Nedd4 NEDD4 E3 ubiquitin protein ligase IDA PMID:20159449 UniProt PMID:20159449 RGD:8554407 NCBI chr 8:79,323,408...79,408,842
Ensembl chr 8:79,323,408...79,408,833
JBrowse link
G Peli1 pellino E3 ubiquitin protein ligase 1 ISO (PMID:29883609) RGD PMID:29883609 NCBI chr14:106,008,086...106,062,566
Ensembl chr14:106,008,086...106,061,641
JBrowse link
G Peli3 pellino E3 ubiquitin protein ligase family member 3 ISO
IBA
(MGI:MGI:5562512|PMID:23892723)
PMID:21873635
RGD PMID:23892723, PMID:21873635 MGI:MGI:5562512, RGD:13792537 NCBI chr 1:220,191,209...220,204,032
Ensembl chr 1:220,190,067...220,204,032
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISS
ISO
GO_REF:0000024
(PMID:15728840), (PMID:17314283), (PMID:19880420), (PMID:25621951)
ParkinsonsUK-UCL
RGD
PMID:15728840, PMID:17314283, PMID:19880420, PMID:25621951 GO_REF:0000024 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Prpf19 pre-mRNA processing factor 19 ISS
ISO
GO_REF:0000024
(PMID:20595234), (PMID:24332808)
UniProt
RGD
PMID:20595234, PMID:24332808 GO_REF:0000024 NCBI chr 1:226,947,065...226,958,147
Ensembl chr 1:226,947,105...226,958,144
JBrowse link
G Rnf115 ring finger protein 115 ISO (MGI:MGI:5582879|PMID:23418353) RGD PMID:23418353 MGI:MGI:5582879 NCBI chr 2:198,852,392...198,920,000
Ensembl chr 2:198,852,500...198,919,995
JBrowse link
G Rnf126 ring finger protein 126 ISO (MGI:MGI:5582879|PMID:23418353) RGD PMID:23418353 MGI:MGI:5582879 NCBI chr 7:12,820,796...12,828,325
Ensembl chr 7:12,820,840...12,828,334
JBrowse link
G Rnf135 ring finger protein 135 ISO
ISS
(PMID:31006531)
GO_REF:0000024
RGD
UniProt
PMID:31006531 GO_REF:0000024 NCBI chr10:67,531,989...67,551,237 JBrowse link
G Rnf152 ring finger protein 152 ISO
ISS
(PMID:25936802)
GO_REF:0000024
RGD
UniProt
PMID:25936802 GO_REF:0000024 NCBI chr13:25,183,295...25,262,785
Ensembl chr13:25,186,106...25,262,469
JBrowse link
G Rnf168 ring finger protein 168 ISO
ISS
(PMID:22266820)
GO_REF:0000024
RGD
UniProt
PMID:22266820 GO_REF:0000024 NCBI chr11:71,721,242...71,743,421
Ensembl chr11:71,721,250...71,743,421
JBrowse link
G Rnf186 ring finger protein 186 ISO
IBA
(PMID:23896122)
PMID:21873635
RGD PMID:23896122, PMID:21873635 RGD:13792537 NCBI chr 5:157,416,897...157,418,121
Ensembl chr 5:157,416,897...157,418,121
JBrowse link
G Rnf4 ring finger protein 4 IDA PMID:18408734 UniProt PMID:18408734 RGD:8553731 NCBI chr14:81,658,400...81,679,756
Ensembl chr14:81,660,354...81,679,082
JBrowse link
G Rnf5 ring finger protein 5 ISO (PMID:19269966) RGD PMID:19269966 NCBI chr20:4,366,244...4,368,690
Ensembl chr20:4,366,246...4,368,693
JBrowse link
G Rnf8 ring finger protein 8 ISO
IEA
ISS
(PMID:21911360)
GO_REF:0000104
GO_REF:0000024
RGD
UniProt
PMID:21911360 GO_REF:0000024, GO_REF:0000104 NCBI chr20:8,285,380...8,309,858
Ensembl chr20:8,285,296...8,309,908
JBrowse link
G Stub1 STIP1 homology and U-box containing protein 1 ISO (PMID:16307917) RGD PMID:16307917 NCBI chr10:15,197,754...15,200,035
Ensembl chr10:15,197,803...15,200,117
JBrowse link
G Traf1 TNF receptor-associated factor 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:14,003,340...14,022,955
Ensembl chr 3:14,003,340...14,022,672
JBrowse link
G Traf2 Tnf receptor-associated factor 2 ISO
IBA
(PMID:15258597), (PMID:20577214)
PMID:21873635
RGD PMID:15258597, PMID:20577214, PMID:21873635 RGD:13792537 NCBI chr 3:2,746,061...2,770,690
Ensembl chr 3:2,746,075...2,770,620
JBrowse link
G Traf3 Tnf receptor-associated factor 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:135,610,698...135,720,247
Ensembl chr 6:135,610,743...135,718,564
JBrowse link
G Traf3ip2 Traf3 interacting protein 2 ISO (PMID:19825828) RGD PMID:19825828 NCBI chr20:44,679,861...44,722,874
Ensembl chr20:44,680,449...44,722,872
JBrowse link
G Traf4 Tnf receptor associated factor 4 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:65,418,688...65,424,802
Ensembl chr10:65,418,700...65,424,802
JBrowse link
G Traf5 TNF receptor-associated factor 5 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:110,758,556...110,801,871
Ensembl chr13:110,758,761...110,784,209
JBrowse link
G Traf6 TNF receptor associated factor 6 ISO
IBA
ISS
(MGI:MGI:3610521|PMID:16252010)
PMID:21873635
UniProtKB:P0CG47 (PMID:17135271), (PMID:19675569), (PMID:19713527), (PMID:21068390)
GO_REF:0000024
RGD
UniProt
PMID:16252010, PMID:17135271, PMID:19675569, PMID:19713527, PMID:21068390, PMID:21873635 GO_REF:0000024, MGI:MGI:3610521, RGD:13792537 NCBI chr 3:91,252,829...91,271,607
Ensembl chr 3:91,252,829...91,271,607
JBrowse link
G Trim27 tripartite motif-containing 27 ISO
IBA
(PMID:23452853)
PMID:21873635
RGD PMID:23452853, PMID:21873635 RGD:13792537 NCBI chr17:45,613,863...45,626,212
Ensembl chr17:45,613,864...45,626,212
JBrowse link
G Trim5 tripartite motif-containing 5 ISO (PMID:21512573) RGD PMID:21512573 NCBI chr 1:169,446,774...169,463,760
Ensembl chr 1:169,446,805...169,534,896
JBrowse link
G Ube2b ubiquitin-conjugating enzyme E2B ISO
ISS
(PMID:20061386)
GO_REF:0000024
RGD
UniProt
PMID:20061386 GO_REF:0000024 NCBI chr10:37,439,947...37,454,867
Ensembl chr10:37,441,284...37,455,022
JBrowse link
G Ube2d4 ubiquitin-conjugating enzyme E2D 4 (putative) ISO (PMID:20061386) RGD PMID:20061386 NCBI chr14:2,933,097...2,934,571
Ensembl chr14:2,933,100...2,934,571
JBrowse link
G Ube2e2 ubiquitin-conjugating enzyme E2E 2 ISO
IBA
(PMID:20061386)
PMID:21873635
RGD PMID:20061386, PMID:21873635 RGD:13792537 NCBI chr15:7,402,210...7,928,320
Ensembl chr15:7,871,497...7,927,939
JBrowse link
G Ube2e3 ubiquitin-conjugating enzyme E2E 3 ISO
IBA
(PMID:20061386)
PMID:21873635
RGD PMID:20061386, PMID:21873635 RGD:13792537 NCBI chr 3:65,815,076...65,876,256
Ensembl chr 3:65,815,080...65,871,363
JBrowse link
G Ube2g1 ubiquitin-conjugating enzyme E2G 1 ISO
ISS
(PMID:20061386)
GO_REF:0000024
RGD
UniProt
PMID:20061386 GO_REF:0000024 NCBI chr10:59,173,268...59,254,458
Ensembl chr10:59,173,268...59,254,453
JBrowse link
G Ube2n ubiquitin-conjugating enzyme E2N ISS
ISO
IBA
GO_REF:0000024
(PMID:16307917), (PMID:20061386), (PMID:21512573), (PMID:25936802), (PMID:31006531)
PMID:21873635
(MGI:MGI:5896692|PMID:28039360), (MGI:MGI:6148454|PMID:22424771)
UniProt
RGD
PMID:16307917, PMID:20061386, PMID:21512573, PMID:22424771, PMID:25936802, PMID:28039360, PMID:31006531, PMID:21873635 GO_REF:0000024, MGI:MGI:5896692, MGI:MGI:6148454, RGD:13792537 NCBI chr 7:36,610,147...36,640,190
Ensembl chr 7:36,610,147...36,640,189
JBrowse link
G Ube2o ubiquitin-conjugating enzyme E2O ISO (PMID:23452853) RGD PMID:23452853 NCBI chr10:105,505,721...105,553,167
Ensembl chr10:105,506,955...105,552,986
JBrowse link
G Ube2s ubiquitin-conjugating enzyme E2S ISO
ISS
(PMID:20061386)
GO_REF:0000024
RGD
UniProt
PMID:20061386 GO_REF:0000024 NCBI chr 1:72,580,424...72,584,484
Ensembl chr 1:72,580,424...72,584,482
JBrowse link
G Ube2t ubiquitin-conjugating enzyme E2T ISO (PMID:20061386) RGD PMID:20061386 NCBI chr13:51,790,877...51,801,379
Ensembl chr13:51,795,867...51,801,163
JBrowse link
G Ube2v1 ubiquitin conjugating enzyme E2 V1 ISO
IBA
(PMID:16307917), (PMID:21512573), (PMID:31006531)
PMID:21873635
RGD PMID:16307917, PMID:21512573, PMID:31006531, PMID:21873635 RGD:13792537 NCBI chr 3:164,343,833...164,366,684
Ensembl chr 3:164,343,833...164,366,684
JBrowse link
G Ube2v2 ubiquitin conjugating enzyme E2 V2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:89,557,273...89,591,175
Ensembl chr11:89,557,273...89,591,175
JBrowse link
G Wwp2 WW domain containing E3 ubiquitin protein ligase 2 ISO
IBA
(MGI:MGI:4821930|PMID:19997087)
PMID:21873635
RGD PMID:19997087, PMID:21873635 MGI:MGI:4821930, RGD:13792537 NCBI chr19:39,543,246...39,614,624
Ensembl chr19:39,543,242...39,614,625
JBrowse link
G Zfp91 zinc finger protein 91 ISO (PMID:20682767) RGD PMID:20682767 NCBI chr 1:229,602,499...229,640,906
Ensembl chr 1:229,602,499...229,639,187
JBrowse link
histone H2A K63-linked ubiquitination term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rnf168 ring finger protein 168 ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:19203578), (PMID:19203579), (PMID:19500350), (PMID:20550933)
UniProt
Ensembl
RGD
PMID:19203578, PMID:19203579, PMID:19500350, PMID:20550933 GO_REF:0000024, GO_REF:0000107 NCBI chr11:71,721,242...71,743,421
Ensembl chr11:71,721,250...71,743,421
JBrowse link
G Rnf8 ring finger protein 8 ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(PMID:20550933), (PMID:22980979)
UniProt
RGD
PMID:20550933, PMID:22980979, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr20:8,285,380...8,309,858
Ensembl chr20:8,285,296...8,309,908
JBrowse link
negative regulation of histone H2A K63-linked ubiquitination term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Otub1 OTU deubiquitinase, ubiquitin aldehyde binding 1 ISO
IBA
ISS
(PMID:20725033)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:20725033, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 1:222,451,674...222,459,952
Ensembl chr 1:222,451,674...222,459,952
JBrowse link
G Otub2 OTU deubiquitinase, ubiquitin aldehyde binding 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:127,282,445...127,301,086
Ensembl chr 6:127,282,466...127,301,083
JBrowse link
G Trip12 thyroid hormone receptor interactor 12 IEA
IBA
ISS
ISO
GO_REF:0000107
PMID:21873635
GO_REF:0000024
(PMID:22884692)
Ensembl
UniProt
RGD
PMID:22884692, PMID:21873635 GO_REF:0000024, GO_REF:0000107, RGD:13792537 NCBI chr 9:92,305,059...92,435,388
Ensembl chr 9:92,305,051...92,435,365
JBrowse link
G Ubr5 ubiquitin protein ligase E3 component n-recognin 5 IEA
IBA
ISS
ISO
GO_REF:0000107
PMID:21873635
GO_REF:0000024
(PMID:22884692)
Ensembl
UniProt
RGD
PMID:22884692, PMID:21873635 GO_REF:0000024, GO_REF:0000107, RGD:13792537 NCBI chr 7:76,789,110...76,835,517
NCBI chr 7:76,839,661...76,907,441
Ensembl chr 7:76,789,531...76,853,840
JBrowse link
negative regulation of protein K63-linked ubiquitination term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gps2 G protein pathway suppressor 2 ISO (MGI:MGI:5896692|PMID:28039360), (MGI:MGI:6148392|PMID:24953653), (MGI:MGI:6148396|PMID:29499132), (MGI:MGI:6148454|PMID:22424771) RGD PMID:22424771, PMID:24953653, PMID:28039360, PMID:29499132 MGI:MGI:5896692, MGI:MGI:6148392, MGI:MGI:6148396, MGI:MGI:6148454 NCBI chr10:56,524,327...56,527,447
Ensembl chr10:56,524,468...56,526,987
JBrowse link
G Parp10 poly (ADP-ribose) polymerase family, member 10 ISO (PMID:23575687) RGD PMID:23575687 NCBI chr 7:117,291,592...117,300,878
Ensembl chr 7:117,291,877...117,300,662
JBrowse link
G Plaa phospholipase A2, activating protein ISO
ISS
(MGI:MGI:5883825|PMID:28413018)
GO_REF:0000024
RGD
UniProt
PMID:28413018 GO_REF:0000024, MGI:MGI:5883825 NCBI chr 5:113,548,913...113,578,928
Ensembl chr 5:113,548,913...113,578,928
JBrowse link
positive regulation of protein K63-linked ubiquitination term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc2 baculoviral IAP repeat-containing 2 ISO (PMID:21931591) RGD PMID:21931591 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142
JBrowse link
G Ddx3x DEAD-box helicase 3, X-linked ISO (PMID:27980081) RGD PMID:27980081 NCBI chr  X:10,400,363...10,414,010
Ensembl chr  X:10,400,366...10,413,995
JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 ISO (PMID:25891078) RGD PMID:25891078 NCBI chr19:19,342,061...19,389,366
Ensembl chr19:19,332,594...19,377,492
JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 ISO
IBA
(PMID:23871208)
(MGI:MGI:5562517|PMID:23871208)
PMID:21873635
RGD PMID:23871208, PMID:21873635 MGI:MGI:5562517, RGD:13792537 NCBI chr 2:206,342,066...206,390,348
Ensembl chr 2:206,342,066...206,390,348
JBrowse link
regulation of protein K63-linked ubiquitination term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sash1 SAM and SH3 domain containing 1 ISO (PMID:23776175) RGD PMID:23776175 NCBI chr 1:2,782,905...2,950,749
Ensembl chr 1:2,782,864...2,846,200
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    metabolic process 12278
      cellular metabolic process 11085
        cellular macromolecule metabolic process 8554
          cellular protein metabolic process 5570
            cellular protein modification process 3949
              protein modification by small protein conjugation or removal 952
                protein modification by small protein conjugation 816
                  protein ubiquitination 767
                    protein polyubiquitination 241
                      protein K63-linked ubiquitination 58
                        histone H2A K63-linked ubiquitination + 6
                        negative regulation of protein K63-linked ubiquitination + 7
                        positive regulation of protein K63-linked ubiquitination + 4
                        regulation of protein K63-linked ubiquitination + 12
Path 2
Term Annotations click to browse term
  biological_process 20027
    metabolic process 12278
      organic substance metabolic process 11660
        macromolecule metabolic process 10098
          protein metabolic process 6264
            protein modification process 3949
              cellular protein modification process 3949
                protein modification by small protein conjugation or removal 952
                  protein modification by small protein conjugation 816
                    protein ubiquitination 767
                      protein polyubiquitination 241
                        protein K63-linked ubiquitination 58
                          histone H2A K63-linked ubiquitination + 6
                          negative regulation of protein K63-linked ubiquitination + 7
                          positive regulation of protein K63-linked ubiquitination + 4
                          regulation of protein K63-linked ubiquitination + 12
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.