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ONTOLOGY REPORT - ANNOTATIONS


Term:histone H2A K63-linked ubiquitination
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Accession:GO:0070535 term browser browse the term
Definition:A histone ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a lysine residue in histone H2A or the variant H2AX.


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histone H2A K63-linked ubiquitination term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rnf168 ring finger protein 168 ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:19203578), (PMID:19203579), (PMID:19500350), (PMID:20550933)
UniProt
Ensembl
RGD
PMID:19203578, PMID:19203579, PMID:19500350, PMID:20550933 GO_REF:0000024, GO_REF:0000107 NCBI chr11:71,721,242...71,743,421
Ensembl chr11:71,721,250...71,743,421
JBrowse link
G Rnf8 ring finger protein 8 ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(PMID:20550933), (PMID:22980979)
UniProt
RGD
PMID:20550933, PMID:22980979, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr20:8,285,380...8,309,858
Ensembl chr20:8,285,296...8,309,908
JBrowse link
negative regulation of histone H2A K63-linked ubiquitination term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Otub1 OTU deubiquitinase, ubiquitin aldehyde binding 1 ISO
ISS
IBA
(PMID:20725033)
GO_REF:0000024
PMID:21873635
RGD
UniProt
PMID:20725033, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 1:222,451,674...222,459,952
Ensembl chr 1:222,451,674...222,459,952
JBrowse link
G Otub2 OTU deubiquitinase, ubiquitin aldehyde binding 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:127,282,445...127,301,086
Ensembl chr 6:127,282,466...127,301,083
JBrowse link
G Trip12 thyroid hormone receptor interactor 12 IEA
IBA
ISS
ISO
GO_REF:0000107
PMID:21873635
GO_REF:0000024
(PMID:22884692)
Ensembl
UniProt
RGD
PMID:22884692, PMID:21873635 GO_REF:0000024, GO_REF:0000107, RGD:13792537 NCBI chr 9:92,305,059...92,435,388
Ensembl chr 9:92,305,051...92,435,365
JBrowse link
G Ubr5 ubiquitin protein ligase E3 component n-recognin 5 IEA
IBA
ISS
ISO
GO_REF:0000107
PMID:21873635
GO_REF:0000024
(PMID:22884692)
Ensembl
UniProt
RGD
PMID:22884692, PMID:21873635 GO_REF:0000024, GO_REF:0000107, RGD:13792537 NCBI chr 7:76,789,110...76,835,517
NCBI chr 7:76,839,661...76,907,441
Ensembl chr 7:76,789,531...76,853,840
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    metabolic process 12278
      organic substance metabolic process 11660
        macromolecule metabolic process 10098
          macromolecule modification 4154
            covalent chromatin modification 514
              histone modification 499
                histone ubiquitination 52
                  histone H2A ubiquitination 29
                    histone H2A K63-linked ubiquitination 6
                      negative regulation of histone H2A K63-linked ubiquitination 4
                      positive regulation of histone H2A K63-linked ubiquitination 0
                      regulation of histone H2A K63-linked ubiquitination + 4
Path 2
Term Annotations click to browse term
  biological_process 20027
    metabolic process 12278
      organic substance metabolic process 11660
        macromolecule metabolic process 10098
          protein metabolic process 6264
            protein modification process 3949
              cellular protein modification process 3949
                protein modification by small protein conjugation or removal 952
                  protein modification by small protein conjugation 816
                    protein ubiquitination 767
                      protein polyubiquitination 241
                        protein K63-linked ubiquitination 58
                          histone H2A K63-linked ubiquitination 6
                            negative regulation of histone H2A K63-linked ubiquitination 4
                            positive regulation of histone H2A K63-linked ubiquitination 0
                            regulation of histone H2A K63-linked ubiquitination + 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.