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ONTOLOGY REPORT - ANNOTATIONS


Term:response to interleukin-6
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Accession:GO:0070741 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus.
Synonyms:exact_synonym: response to IL-6


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response to interleukin-6 term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldob aldolase, fructose-bisphosphate B IEP RGD PMID:7625825 RGD:2313427 NCBI chr 5:64,805,772...64,818,813
Ensembl chr 5:64,805,773...64,818,824
JBrowse link
G Chi3l1 chitinase 3 like 1 ISO
ISS
(PMID:21478032)
GO_REF:0000024
RGD
UniProt
PMID:21478032 GO_REF:0000024 NCBI chr13:51,022,844...51,030,797
Ensembl chr13:51,022,681...51,030,802
JBrowse link
G Cited1 Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 ISO
ISS
(MGI:MGI:1312962|PMID:9811838)
GO_REF:0000024
RGD
UniProt
PMID:9811838 GO_REF:0000024, MGI:MGI:1312962 NCBI chr  X:72,128,996...72,133,692
Ensembl chr  X:72,128,994...72,133,692
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 IEP RGD PMID:17805558 RGD:10445833 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871
JBrowse link
G Sftpa1 surfactant protein A1 IEP RGD PMID:11000512 RGD:4144154 NCBI chr16:18,716,019...18,719,404
Ensembl chr16:18,716,019...18,719,403
JBrowse link
G Sftpb surfactant protein B IEP RGD PMID:11000512 RGD:4144154 NCBI chr 4:100,166,855...100,175,941
Ensembl chr 4:100,166,863...100,175,938
JBrowse link
G Sftpc surfactant protein C IEP RGD PMID:11000512 RGD:4144154 NCBI chr15:52,211,538...52,214,480
Ensembl chr15:52,211,544...52,214,616
JBrowse link
cellular response to interleukin-6 term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 IEP RGD PMID:20702406 RGD:11081005 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Aqp4 aquaporin 4 IEP RGD PMID:22449442 RGD:8695996 NCBI chr18:6,766,009...6,782,757
Ensembl chr18:6,765,945...6,782,996
JBrowse link
G Camp cathelicidin antimicrobial peptide IEP RGD PMID:19879657 RGD:2316237 NCBI chr 8:117,930,557...117,932,371
Ensembl chr 8:117,930,546...117,932,518
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 IEP RGD PMID:8921263 RGD:8549522 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cfi complement factor I IEP RGD PMID:11530941 RGD:8662322 NCBI chr 2:235,264,149...235,305,779
Ensembl chr 2:235,264,219...235,305,781
JBrowse link
G Cfl1 cofilin 1 IDA RGD PMID:24760020 RGD:11570414 NCBI chr 1:220,869,805...220,873,337
Ensembl chr 1:220,869,805...220,873,337
JBrowse link
G Crp C-reactive protein IEP RGD PMID:20100497 RGD:9586010 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Entpd2 ectonucleoside triphosphate diphosphohydrolase 2 IMP RGD PMID:18202114 RGD:9685526 NCBI chr 3:2,617,795...2,623,818
Ensembl chr 3:2,617,805...2,623,445
JBrowse link
G Fcar Fc fragment of IgA receptor ISO (PMID:25339672) RGD PMID:25339672 NCBI chr 1:73,230,392...73,263,462
Ensembl chr 1:73,230,390...73,264,302
JBrowse link
G Fga fibrinogen alpha chain IEP RGD PMID:9488469 RGD:9685026 NCBI chr 2:181,997,562...182,013,726
Ensembl chr 2:182,006,242...182,013,763
JBrowse link
G Fgf23 fibroblast growth factor 23 IEP RGD PMID:23263654 RGD:10044209 NCBI chr 4:159,622,404...159,630,082
Ensembl chr 4:159,622,404...159,630,082
JBrowse link
G Fgg fibrinogen gamma chain IEP RGD PMID:11071643 RGD:731198 NCBI chr 2:181,987,080...181,994,523
Ensembl chr 2:181,987,217...181,994,514
JBrowse link
G Ghrh growth hormone releasing hormone IEP RGD PMID:19239705 RGD:5687170 NCBI chr 3:153,449,124...153,468,794
Ensembl chr 3:153,449,125...153,468,794
JBrowse link
G Hamp hepcidin antimicrobial peptide IEP RGD PMID:23506423 RGD:11041627 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960
JBrowse link
G Icam1 intercellular adhesion molecule 1 IEP RGD PMID:7865494 RGD:11520781 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase IEP RGD PMID:8853431 RGD:70321 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
JBrowse link
G Mir125a microRNA 125a IEP RGD PMID:29700287 RGD:26884455 NCBI chr 1:59,704,827...59,704,911
Ensembl chr 1:59,704,827...59,704,911
JBrowse link
G Mir155 microRNA 155 ISO (MGI:MGI:5556350|PMID:24391219) RGD PMID:24391219 MGI:MGI:5556350 NCBI chr11:24,176,603...24,176,667
Ensembl chr11:24,176,603...24,176,667
JBrowse link
G Mir21 microRNA 21 ISO (MGI:MGI:5556350|PMID:24391219) RGD PMID:24391219 MGI:MGI:5556350 NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301
JBrowse link
G Myb MYB proto-oncogene, transcription factor ISO (MGI:MGI:3620307|PMID:16162816) RGD PMID:16162816 MGI:MGI:3620307 NCBI chr 1:16,658,178...16,690,135
Ensembl chr 1:16,659,442...16,687,817
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 ISO
IEA
(PMID:22357537)
GO_REF:0000107
RGD
Ensembl
PMID:22357537 GO_REF:0000107 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Phb prohibitin ISO (PMID:17324931) RGD PMID:17324931 NCBI chr10:83,476,107...83,488,878
Ensembl chr10:83,476,107...83,488,878
JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 ISO (MGI:MGI:5308004|PMID:19894142) RGD PMID:19894142 MGI:MGI:5308004 NCBI chr 9:91,667,748...91,683,468
Ensembl chr 9:91,665,986...91,882,927
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha IEP RGD PMID:23692924 RGD:10059632 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Ptgis prostaglandin I2 synthase ISO
ISS
(PMID:8185632)
GO_REF:0000024
RGD
UniProt
PMID:8185632 GO_REF:0000024 NCBI chr 3:163,950,746...163,986,129 JBrowse link
G Ptprt protein tyrosine phosphatase, receptor type, T ISO (PMID:17360477) RGD PMID:17360477 NCBI chr 3:157,537,192...158,328,984
Ensembl chr 3:157,544,583...158,328,881
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO (PMID:22357537) RGD PMID:22357537 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sbno2 strawberry notch homolog 2 ISO
IBA
(PMID:25903009)
PMID:21873635
(MGI:MGI:5660440|PMID:25903009)
RGD PMID:25903009, PMID:21873635 MGI:MGI:5660440, RGD:13792537 NCBI chr 7:12,471,805...12,515,700
Ensembl chr 7:12,471,824...12,518,654
JBrowse link
G Selplg selectin P ligand ISO (PMID:9486531) RGD PMID:9486531 NCBI chr12:48,577,905...48,579,196
Ensembl chr12:48,577,905...48,579,196
JBrowse link
G Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N IEP RGD PMID:8611141 RGD:5147422 NCBI chr 6:128,073,344...128,080,878
Ensembl chr 6:127,941,526...128,080,889
JBrowse link
G St3gal6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 ISO
ISS
(PMID:17944600)
GO_REF:0000024
RGD
UniProt
PMID:17944600 GO_REF:0000024 NCBI chr11:44,176,518...44,237,119
Ensembl chr11:44,192,940...44,237,100
JBrowse link
G Tdgf1 teratocarcinoma-derived growth factor 1 ISO (PMID:17720976) RGD PMID:17720976 NCBI chr 8:119,215,266...119,220,909
Ensembl chr 8:119,215,495...119,219,232
JBrowse link
G Traf7 TNF receptor associated factor 7 ISO (MGI:MGI:3620307|PMID:16162816) RGD PMID:16162816 MGI:MGI:3620307 NCBI chr10:13,874,444...13,893,090
Ensembl chr10:13,874,456...13,892,997
JBrowse link
interleukin-6-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cebpa CCAAT/enhancer binding protein alpha IEA
ISO
GO_REF:0000107
(PMID:24429361)
Ensembl
RGD
PMID:24429361 GO_REF:0000107 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Ctr9 CTR9 homolog, Paf1/RNA polymerase II complex component ISO (MGI:MGI:5319608|PMID:17911113) RGD PMID:17911113 MGI:MGI:5319608 NCBI chr 1:175,839,140...175,869,167
Ensembl chr 1:175,839,108...175,869,165
JBrowse link
G Fer FER tyrosine kinase IEA
ISO
GO_REF:0000107
(PMID:19147545)
Ensembl
RGD
PMID:19147545 GO_REF:0000107 NCBI chr 9:111,557,804...111,868,583
Ensembl chr 9:111,597,037...111,862,670
JBrowse link
G Gab1 GRB2-associated binding protein 1 ISO MGI:MGI:1926435 (MGI:MGI:1355592|PMID:10779359) RGD PMID:10779359 MGI:MGI:1355592 NCBI chr19:30,794,290...30,903,819
Ensembl chr19:30,794,571...30,902,008
JBrowse link
G Il6 interleukin 6 ISO
ISS
(PMID:12552091), (PMID:16946298), (PMID:30670152)
(MGI:MGI:3769957|PMID:16330325), (MGI:MGI:50330|PMID:1312474), (MGI:MGI:6142555|PMID:27893700), (MGI:MGI:84432|PMID:8910279)
GO_REF:0000024
RGD
UniProt
PMID:1312474, PMID:8910279, PMID:12552091, PMID:16330325, PMID:16946298, PMID:27893700, PMID:30670152 GO_REF:0000024, MGI:MGI:3769957, MGI:MGI:50330, MGI:MGI:6142555, MGI:MGI:84432 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Il6r interleukin 6 receptor ISO
ISS
IBA
IEA
(PMID:12643274)
(MGI:MGI:50330|PMID:1312474), (MGI:MGI:6142555|PMID:27893700)
GO_REF:0000024
PMID:21873635
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:1312474, PMID:12643274, PMID:27893700, PMID:21873635 GO_REF:0000024, GO_REF:0000107, MGI:MGI:50330, MGI:MGI:6142555, RGD:13792537 NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628
JBrowse link
G Il6st interleukin 6 signal transducer IMP
IEA
ISO
GO_REF:0000107
(MGI:MGI:5629863|PMID:25731159)
(PMID:12643274), (PMID:2261637), (PMID:25731159)
Ensembl
RGD
PMID:2261637, PMID:12643274, PMID:25731159, PMID:18280048 GO_REF:0000107, MGI:MGI:5629863, RGD:5686900 NCBI chr 2:44,279,199...44,319,427
Ensembl chr 2:44,289,393...44,314,944
JBrowse link
G Smad4 SMAD family member 4 ISO
IEA
(MGI:MGI:3769957|PMID:16330325)
GO_REF:0000107
RGD
Ensembl
PMID:16330325 GO_REF:0000107, MGI:MGI:3769957 NCBI chr18:69,626,682...69,657,373
Ensembl chr18:69,627,757...69,671,199
JBrowse link
G Spi1 Spi-1 proto-oncogene ISO (PMID:24429361) RGD PMID:24429361 NCBI chr 3:79,918,127...79,937,708
Ensembl chr 3:79,918,969...79,938,301
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO (PMID:25731159)
(MGI:MGI:5629863|PMID:25731159)
RGD PMID:25731159 MGI:MGI:5629863 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G St18 ST18 C2H2C-type zinc finger transcription factor IEA
ISO
GO_REF:0000107
(PMID:18676404)
Ensembl
RGD
PMID:18676404 GO_REF:0000107 NCBI chr 5:12,437,617...12,787,223
Ensembl chr 5:12,437,525...12,563,429
JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISS
ISO
GO_REF:0000024
(PMID:12359225), (PMID:12552091), (PMID:16835372), (PMID:16946298), (PMID:17324931), (PMID:24429361)
UniProt
RGD
PMID:12359225, PMID:12552091, PMID:16835372, PMID:16946298, PMID:17324931, PMID:24429361 GO_REF:0000024 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tut4 terminal uridylyl transferase 4 ISO (MGI:MGI:4365679|PMID:19701194) RGD PMID:19701194 MGI:MGI:4365679 NCBI chr 5:128,063,880...128,168,726
Ensembl chr 5:128,083,118...128,168,207
JBrowse link
G Yap1 Yes1 associated transcriptional regulator ISO (PMID:25731159)
(MGI:MGI:5629863|PMID:25731159)
RGD PMID:25731159 MGI:MGI:5629863 NCBI chr 8:6,133,014...6,204,240
Ensembl chr 8:6,135,493...6,203,579
JBrowse link
negative regulation of interleukin-6-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il6st interleukin 6 signal transducer ISO (PMID:8353278) RGD PMID:8353278 NCBI chr 2:44,279,199...44,319,427
Ensembl chr 2:44,289,393...44,314,944
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 ISO
ISS
(PMID:12359225)
GO_REF:0000024
(MGI:MGI:4941441|PMID:20484139)
RGD
UniProt
PMID:12359225, PMID:20484139 GO_REF:0000024, MGI:MGI:4941441 NCBI chr18:63,415,298...63,489,240
Ensembl chr18:63,415,306...63,488,027
JBrowse link
positive regulation of interleukin-6-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1qtnf4 C1q and TNF related 4 ISO (PMID:21658842) RGD PMID:21658842 NCBI chr 3:79,713,580...79,718,018
Ensembl chr 3:79,713,567...79,718,025
JBrowse link
G Gfi1 growth factor independent 1 transcriptional repressor ISO (PMID:11060035) RGD PMID:11060035 NCBI chr14:3,058,035...3,073,332
Ensembl chr14:3,058,993...3,068,371
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 ISO (PMID:31827280)
(MGI:MGI:6401044|PMID:31827281)
RGD PMID:31827280, PMID:31827281 MGI:MGI:6401044 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    response to stimulus 10583
      response to chemical 6343
        response to organic substance 3865
          response to cytokine 1132
            response to interleukin-6 58
              cellular response to interleukin-6 + 51
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.