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ONTOLOGY REPORT - ANNOTATIONS


Term:gamma-secretase complex
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Accession:GO:0070765 term browser browse the term
Definition:A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of the GxGD-type aspartyl peptidases. The complex also contains additional subunits, including nicastrin, APH-1, PEN-2, and a regulatory subunit, CD147. Gamma-secretase cleaves several transmembrane proteins including the cell surface receptor Notch and the amyloid-beta precursor protein.
Synonyms:narrow_synonym: CD147-gamma-secretase complex (APH-1a, PS-1, PEN-2, NCT variant);   gamma-secretase complex (APH1A, PSEN1, PSENEN, NCSTN variant);   gamma-secretase complex (APH1A, PSEN2, PSENEN, NCSTN);   gamma-secretase complex (APH1B, PSEN2, PSENEN, NCSTN)
 related_synonym: gamma-secretase complex (APH1B, PSEN1, PSENEN, NCSTN)


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gamma-secretase complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aph1a aph-1 homolog A, gamma secretase subunit JBrowse link 2 198,006,247 198,009,837 RGD:1624291
RGD:13792537
G Aph1b aph-1 homolog B, gamma secretase subunit JBrowse link 8 72,508,008 72,598,921 RGD:13792537
G LOC108348064 gamma-secretase subunit APH-1B-like JBrowse link 8 72,608,217 72,629,257 RGD:13792537
G Ncstn nicastrin JBrowse link 13 90,451,046 90,467,256 RGD:1600115
RGD:1624291
G Psen1 presenilin 1 JBrowse link 6 107,169,514 107,221,000 RGD:1600115
RGD:1624291
G Psenen presenilin enhancer gamma secretase subunit JBrowse link 1 89,016,093 89,017,449 RGD:1600115
RGD:13792537
RGD:1624291
G Tmed10 transmembrane p24 trafficking protein 10 JBrowse link 6 109,169,739 109,205,004 RGD:2317342
RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19951
    protein-containing complex 5828
      membrane protein complex 1228
        plasma membrane protein complex 560
          gamma-secretase complex 7
Path 2
Term Annotations click to browse term
  cellular_component 19951
    cellular anatomical entity 19598
      membrane 9983
        plasma membrane 6132
          plasma membrane protein complex 560
            gamma-secretase complex 7
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.