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ONTOLOGY REPORT - ANNOTATIONS


Term:PAS complex
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Accession:GO:0070772 term browser browse the term
Definition:A class III phosphatidylinositol 3-kinase complex that contains a phosphatidylinositol-3-phosphate 5-kinase subunit (Fab1p in yeast; PIKfyve in mammals), a kinase activator, and a phosphatase, and may also contain additional proteins; it is involved in regulating the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate. In mammals the complex is composed of PIKFYVE, FIG4 and VAC14. In yeast it is composed of Atg18p, Fig4p, Fab1p, Vac14p and Vac7p.
Synonyms:related_synonym: autophagy-specific phosphatidylinositol 3-kinase complex


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PAS complex term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vac14 VAC14 component of PIKFYVE complex IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:40,927,007...41,029,206
Ensembl chr19:40,927,007...41,029,206
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  cellular_component 20609
    cellular anatomical entity 20358
      cytoplasm 11456
        vacuole 585
          vacuolar membrane 267
            PAS complex 1
Path 2
Term Annotations click to browse term
  cellular_component 20609
    cellular anatomical entity 20358
      organelle 13258
        membrane-bounded organelle 11449
          organelle membrane 2878
            bounding membrane of organelle 1532
              vacuolar membrane 267
                PAS complex 1
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