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Term:PAS complex
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Accession:GO:0070772 term browser browse the term
Definition:A class III phosphatidylinositol 3-kinase complex that contains a phosphatidylinositol-3-phosphate 5-kinase subunit (Fab1p in yeast; PIKfyve in mammals), a kinase activator, and a phosphatase, and may also contain additional proteins; it is involved in regulating the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate. In mammals the complex is composed of PIKFYVE, FIG4 and VAC14. In yeast it is composed of Atg18p, Fig4p, Fab1p, Vac14p and Vac7p.
Synonyms:related_synonym: autophagy-specific phosphatidylinositol 3-kinase complex

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  cellular_component 12666
    protein-containing complex 3938
      membrane protein complex 822
        phosphatidylinositol 3-kinase complex 12
          phosphatidylinositol 3-kinase complex, class III 5
            PAS complex 0
Path 2
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  cellular_component 12666
    cellular anatomical entity 12562
      organelle 9741
        membrane-bounded organelle 8625
          organelle membrane 1663
            bounding membrane of organelle 900
              vacuolar membrane 154
                PAS complex 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.