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ONTOLOGY REPORT - ANNOTATIONS


Term:PAS complex
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Accession:GO:0070772 term browser browse the term
Definition:A class III phosphatidylinositol 3-kinase complex that contains a phosphatidylinositol-3-phosphate 5-kinase subunit (Fab1p in yeast; PIKfyve in mammals), a kinase activator, and a phosphatase, and may also contain additional proteins; it is involved in regulating the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate. In mammals the complex is composed of PIKFYVE, FIG4 and VAC14. In yeast it is composed of Atg18p, Fig4p, Fab1p, Vac14p and Vac7p.
Synonyms:related_synonym: autophagy-specific phosphatidylinositol 3-kinase complex


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PAS complex term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G VAC14 VAC14 component of PIKFYVE complex IEA
IBA
(PMID:21873635) InterPro
GO_Central
PMID:21873635 GO_REF:0000002 NCBI chr16:70,687,439...70,801,158
Ensembl chr16:70,687,439...70,801,160
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Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19334
    protein-containing complex 5896
      membrane protein complex 1381
        phosphatidylinositol 3-kinase complex 29
          phosphatidylinositol 3-kinase complex, class III 7
            PAS complex 1
Path 2
Term Annotations click to browse term
  cellular_component 19334
    cellular anatomical entity 19125
      organelle 14294
        membrane-bounded organelle 12918
          organelle membrane 3757
            bounding membrane of organelle 2247
              vacuolar membrane 446
                PAS complex 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.