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Term:PAS complex
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Accession:GO:0070772 term browser browse the term
Definition:A class III phosphatidylinositol 3-kinase complex that contains a phosphatidylinositol-3-phosphate 5-kinase subunit (Fab1p in yeast; PIKfyve in mammals), a kinase activator, and a phosphatase, and may also contain additional proteins; it is involved in regulating the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate. In mammals the complex is composed of PIKFYVE, FIG4 and VAC14. In yeast it is composed of Atg18p, Fig4p, Fab1p, Vac14p and Vac7p.
Synonyms:related_synonym: autophagy-specific phosphatidylinositol 3-kinase complex

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PAS complex term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vac14 Vac14 homolog (S. cerevisiae) IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr 8:110,618,529...110,720,398
Ensembl chr 8:110,618,585...110,720,398
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  cellular_component 23195
    protein-containing complex 5493
      membrane protein complex 1175
        phosphatidylinositol 3-kinase complex 29
          phosphatidylinositol 3-kinase complex, class III 7
            PAS complex 1
Path 2
Term Annotations click to browse term
  cellular_component 23195
    cellular anatomical entity 19140
      organelle 12896
        membrane-bounded organelle 11529
          organelle membrane 2238
            bounding membrane of organelle 1167
              vacuolar membrane 194
                PAS complex 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.