Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   


Term:PAS complex
go back to main search page
Accession:GO:0070772 term browser browse the term
Definition:A class III phosphatidylinositol 3-kinase complex that contains a phosphatidylinositol-3-phosphate 5-kinase subunit (Fab1p in yeast; PIKfyve in mammals), a kinase activator, and a phosphatase, and may also contain additional proteins; it is involved in regulating the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate. In mammals the complex is composed of PIKFYVE, FIG4 and VAC14. In yeast it is composed of Atg18p, Fig4p, Fab1p, Vac14p and Vac7p.
Synonyms:related_synonym: autophagy-specific phosphatidylinositol 3-kinase complex

show annotations for term's descendants           Sort by:
PAS complex term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G VAC14 VAC14 component of PIKFYVE complex IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:13,683,800...13,791,246
Ensembl chr 6:13,683,799...13,791,241
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 16940
    protein-containing complex 4975
      membrane protein complex 1120
        phosphatidylinositol 3-kinase complex 28
          phosphatidylinositol 3-kinase complex, class III 7
            PAS complex 1
Path 2
Term Annotations click to browse term
  cellular_component 16940
    cellular anatomical entity 16852
      organelle 11466
        membrane-bounded organelle 10091
          organelle membrane 2377
            bounding membrane of organelle 1316
              vacuolar membrane 217
                PAS complex 1
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.