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ONTOLOGY REPORT - ANNOTATIONS


Term:phosphatidylserine exposure on apoptotic cell surface
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Accession:GO:0070782 term browser browse the term
Definition:A phospholipid scrambling process that results in the appearance of phosphatidylserine on the outer leaflet of the plasma membrane of an apoptotic cell, which acts as an 'eat-me' signal for engulfing cells. Phosphatidylserine is exposed on the apoptotic cell surface by a phospholipid scramblase activity.
Comment:In normal cells, phosphatidylserine residues are found exclusively on the inner side of the cellular membrane. During apoptosis, phosphatidylserine is transported to the outer cell surface by scramblase proteins. This event acts as an "eat-me" signal for macrophages to dispose of the dying cell. When annotating to this term, curators should be aware of the following: 1) phosphatidylserine exposure on the cell surface can occur in circumstances other than apoptosis (for example, when blood platelets are activated, they expose phosphatidylserine to trigger the clotting system, see PMID:21107324). Do not annotate to GO:0070782 unless phosphatidylserine exposure is shown to be part of an apoptotic event. 2) Caution should be applied when a study quotes annexin V assays. The annexin A5 protein binds to phosphatidylserine-containing membrane surfaces, which are usually only present on the inner leaflet of the membrane. However, in cells undergoing apoptosis, phosphatidylserine becomes exposed on the outer leaflet of the membrane. A positive annexin assay can therefore be linked to apoptotic death, but it shouldn't be confused with molecular events strictly involved in the process of phosphatidylserine exposure.
Synonyms:exact_synonym: externalization of phosphatidylserine


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phosphatidylserine exposure on apoptotic cell surface term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ano6 anoctamin 6 NOT ISO MGI:MGI:4127698 (MGI:MGI:5486117|PMID:22936354), (MGI:MGI:5496475|PMID:23532839) RGD PMID:22936354, PMID:23532839 MGI:MGI:5486117, MGI:MGI:5496475 NCBI chr 7:137,142,063...137,335,208
Ensembl chr 7:137,142,170...137,335,208
JBrowse link
G Plscr1 phospholipid scramblase 1 IEA
ISO
ISS
IBA
GO_REF:0000107
(MGI:MGI:5284813|PMID:12509439), (MGI:MGI:6450314|PMID:32110987)
GO_REF:0000024
(PMID:32110987)
PMID:21873635
Ensembl
RGD
UniProt
PMID:12509439, PMID:32110987, PMID:21873635 GO_REF:0000024, GO_REF:0000107, MGI:MGI:5284813, MGI:MGI:6450314, RGD:13792537 NCBI chr 8:99,625,523...99,645,882
Ensembl chr 8:99,625,545...99,725,217
JBrowse link
G Trpc5 transient receptor potential cation channel, subfamily C, member 5 ISO (MGI:MGI:6450314|PMID:32110987) RGD PMID:32110987 MGI:MGI:6450314 NCBI chr  X:115,624,670...115,908,248
Ensembl chr  X:115,627,653...115,908,693
JBrowse link
G Xkr4 XK related 4 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:15,746,012...16,141,059
Ensembl chr 5:15,747,614...16,140,896
JBrowse link
G Xkr5 XK related 5 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:75,744,786...75,762,694
Ensembl chr16:75,744,786...75,762,693
JBrowse link
G Xkr6 XK related 6 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:46,784,963...47,173,352
Ensembl chr15:46,784,963...47,173,335
JBrowse link
G Xkr7 XK related 7 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:148,508,622...148,537,904
Ensembl chr 3:148,510,779...148,533,404
JBrowse link
G Xkr8 XK related 8 ISO
IBA
(PMID:23845944)
MGI:MGI:5528895 (MGI:MGI:5502792|PMID:23845944), (MGI:MGI:6120635|PMID:29440417)
PMID:21873635
RGD PMID:23845944, PMID:29440417, PMID:21873635 MGI:MGI:5502792, MGI:MGI:6120635, RGD:13792537 NCBI chr 5:150,918,600...150,925,727
Ensembl chr 5:150,918,603...150,925,727
JBrowse link
G Xkr9 XK related 9 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:4,946,332...4,975,436
Ensembl chr 5:4,946,006...4,975,436
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    cellular process 18800
      execution phase of apoptosis 74
        phosphatidylserine exposure on apoptotic cell surface 9
          negative regulation of phosphatidylserine exposure on apoptotic cell surface 0
          positive regulation of phosphatidylserine exposure on apoptotic cell surface 0
          regulation of phosphatidylserine exposure on apoptotic cell surface + 0
Path 2
Term Annotations click to browse term
  biological_process 20028
    localization 6478
      establishment of localization 4887
        transport 4735
          ion transport 1786
            anion transport 679
              organic anion transport 535
                phospholipid transport 98
                  phospholipid translocation 54
                    plasma membrane phospholipid scrambling 25
                      phosphatidylserine exposure on apoptotic cell surface 9
                        negative regulation of phosphatidylserine exposure on apoptotic cell surface 0
                        positive regulation of phosphatidylserine exposure on apoptotic cell surface 0
                        regulation of phosphatidylserine exposure on apoptotic cell surface + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.