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ONTOLOGY REPORT - ANNOTATIONS


Term:response to epidermal growth factor
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Accession:GO:0070849 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.
Synonyms:exact_synonym: response to EGF stimulus;   response to epidermal growth factor stimulus


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response to epidermal growth factor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACOT2 acyl-CoA thioesterase 2 ISO murine EGF RGD PMID:18388199 RGD:2315857 NCBI chr14:54,128,445...54,135,067 JBrowse link
G ASCL1 achaete-scute family bHLH transcription factor 1 ISO RGD PMID:9473334 RGD:2314149 NCBI chr12:100,536,895...100,539,737
Ensembl chr12:103,932,302...103,932,999
JBrowse link
G IGF1 insulin like growth factor 1 ISO RGD PMID:2003595 RGD:12910130 NCBI chr12:99,986,887...100,066,773 JBrowse link
G IL1R1 interleukin 1 receptor type 1 ISO RGD PMID:9233842 RGD:8662880 Ensembl chr2A:103,193,131...103,230,005 JBrowse link
G MAPK1 mitogen-activated protein kinase 1 ISO (PMID:18794356) UniProtKB PMID:18794356 NCBI chr22:3,883,119...3,990,368
Ensembl chr22:20,365,487...20,450,335
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 ISO (PMID:18794356), (PMID:21968647) UniProtKB PMID:18794356, PMID:21968647 Ensembl chr16:30,489,362...30,498,017 JBrowse link
G SERPINE1 serpin family E member 1 ISO RGD PMID:1333984 RGD:8547845 NCBI chr 7:93,267,517...93,279,728
Ensembl chr 7:106,510,130...106,518,450
JBrowse link
G SFTPA1 surfactant protein A1 ISO RGD PMID:19781387 RGD:4143468 NCBI chr10:76,571,312...76,575,820 JBrowse link
G SFTPB surfactant protein B ISO RGD PMID:19781387 RGD:4143468 NCBI chr2A:85,708,485...85,718,120
Ensembl chr2A:87,257,244...87,268,332
JBrowse link
G TPR translocated promoter region, nuclear basket protein ISO (PMID:18794356) UniProtKB PMID:18794356 NCBI chr 1:161,842,037...161,903,567
Ensembl chr 1:165,993,726...166,055,223
JBrowse link
cellular response to epidermal growth factor stimulus term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTR3 actin related protein 3 ISO RGD PMID:10209028 RGD:2306208 NCBI chr2B:827,184...900,424
Ensembl chr2B:114,373,392...114,445,729
JBrowse link
G AKT1 AKT serine/threonine kinase 1 ISO (MGI:MGI:5292318|PMID:21712384) UniProtKB PMID:21712384 MGI:MGI:5292318 NCBI chr14:85,417,229...85,444,722
Ensembl chr14:105,208,128...105,236,756
JBrowse link
G ARPC2 actin related protein 2/3 complex subunit 2 ISO RGD PMID:15252126 RGD:2306210 NCBI chr2B:105,478,035...105,513,665
Ensembl chr2B:224,076,356...224,111,643
JBrowse link
G BAG4 BAG cochaperone 4 ISO (MGI:MGI:5292318|PMID:21712384) UniProtKB PMID:21712384 MGI:MGI:5292318 NCBI chr 8:37,479,231...37,515,303
Ensembl chr 8:34,656,000...34,692,666
JBrowse link
G BAIAP2 BAR/IMD domain containing adaptor protein 2 ISO RGD PMID:17855387 RGD:2306203 NCBI chr17:75,460,491...75,542,700
Ensembl chr17:81,187,021...81,269,714
JBrowse link
G BECN1 beclin 1 ISO RGD PMID:20539009 RGD:6483081 NCBI chr17:14,493,619...14,507,809
Ensembl chr17:14,719,781...14,733,286
JBrowse link
G CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase ISO RGD PMID:10659854 RGD:2303528 NCBI chr2A:27,218,699...27,245,156
Ensembl chr2A:27,306,527...27,332,804
JBrowse link
G CBL Cbl proto-oncogene ISO RGD PMID:22203672 RGD:11576305 NCBI chr11:114,044,996...114,149,204
Ensembl chr11:117,973,187...118,074,671
JBrowse link
G CFL1 cofilin 1 ISO RGD PMID:23704350, PMID:26324884 RGD:11568705, RGD:11570555 NCBI chr11:61,215,092...61,218,628
Ensembl chr11:64,544,275...64,550,806
JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator ISO RGD PMID:16033771 RGD:11341689 NCBI chr2B:88,373,057...88,429,959
Ensembl chr2B:206,528,943...206,577,045
JBrowse link
G COL1A1 collagen type I alpha 1 chain ISO RGD PMID:2016852 RGD:2316227 NCBI chr17:44,274,349...44,291,764
Ensembl chr17:49,150,677...49,166,677
JBrowse link
G DAB2 DAB adaptor protein 2 ISO PMID:12473651 UniProt PMID:12473651 RGD:8553624 NCBI chr 5:70,951,198...71,004,836
Ensembl chr 5:76,022,143...76,041,443
JBrowse link
G DAB2IP DAB2 interacting protein ISO PMID:11812785 BHF-UCL PMID:11812785 RGD:632628 NCBI chr 9:92,696,798...92,912,425
Ensembl chr 9:121,143,457...121,254,336
JBrowse link
G DUSP22 dual specificity phosphatase 22 ISO (PMID:20018849) ARUK-UCL PMID:20018849 NCBI chr 6:107,145...180,777
Ensembl chr 6:242,121...301,248
JBrowse link
G DUSP3 dual specificity phosphatase 3 ISO (MGI:MGI:6101044|PMID:28759036)
(PMID:28759036)
BHF-UCL PMID:28759036 MGI:MGI:6101044 NCBI chr17:13,618,860...13,631,743
Ensembl chr17:13,784,594...13,797,045
JBrowse link
G EEF1A1 eukaryotic translation elongation factor 1 alpha 1 ISO (PMID:9852145) UniProtKB PMID:9852145 NCBI chr 6:71,342,291...71,346,033 JBrowse link
G EGFR epidermal growth factor receptor ISO PMID:20639532 UniProt PMID:20639532 RGD:8553583 NCBI chr 7:55,614,042...55,807,285
Ensembl chr 7:56,046,296...56,111,615
JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 ISO (PMID:27134172) UniProtKB PMID:27134172 NCBI chr17:17,560,337...17,600,808
Ensembl chr17:17,777,434...17,805,862
JBrowse link
G ERBB4 erb-b2 receptor tyrosine kinase 4 ISO (MGI:MGI:82360|PMID:8702723) MGI PMID:8702723 MGI:MGI:82360 NCBI chr2B:98,625,630...99,795,371
Ensembl chr2B:217,069,644...218,272,006
JBrowse link
G ERRFI1 ERBB receptor feedback inhibitor 1 ISO RGD PMID:15556944 RGD:9685545 NCBI chr 1:6,771,619...6,786,217
Ensembl chr 1:8,011,848...8,033,674
JBrowse link
G FOXC1 forkhead box C1 ISO (PMID:16492674) UniProtKB PMID:16492674 NCBI chr 6:1,429,051...1,433,180 JBrowse link
G GAREM1 GRB2 associated regulator of MAPK1 subtype 1 ISO (PMID:19509291) UniProtKB PMID:19509291 NCBI chr18:25,470,702...25,678,146
Ensembl chr18:29,065,053...29,272,231
JBrowse link
G GIT1 GIT ArfGAP 1 ISO RGD PMID:18523162 RGD:13513208 NCBI chr17:27,185,025...27,201,146
Ensembl chr17:27,706,776...27,717,857
JBrowse link
G GRK2 G protein-coupled receptor kinase 2 ISO RGD PMID:24018045 RGD:13792711 NCBI chr11:62,624,647...62,644,846
Ensembl chr11:65,939,164...65,959,066
JBrowse link
G GSTP1 glutathione S-transferase pi 1 ISO RGD PMID:1908848 RGD:2317845 NCBI chr11:62,942,756...62,945,701
Ensembl chr11:66,253,421...66,256,472
JBrowse link
G HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 ISO RGD PMID:3062579 RGD:10041005 NCBI chr12:34,456,900...34,463,317
Ensembl chr12:35,184,943...35,188,443
JBrowse link
G ID1 inhibitor of DNA binding 1, HLH protein ISO RGD PMID:7623812 RGD:9686118 NCBI chr20:27,895,177...27,896,414
Ensembl chr20:28,535,582...28,536,311
JBrowse link
G IGFALS insulin like growth factor binding protein acid labile subunit ISO RGD PMID:8070348 RGD:12911020 NCBI chr16:412,671...418,351
Ensembl chr16:1,843,979...1,848,442
JBrowse link
G INPP5K inositol polyphosphate-5-phosphatase K ISO (PMID:21712384) UniProtKB PMID:21712384 NCBI chr17:1,477,511...1,499,765
Ensembl chr17:1,377,312...1,399,373
JBrowse link
G IQGAP1 IQ motif containing GTPase activating protein 1 ISO (PMID:17563371), (PMID:26242911)
(MGI:MGI:5430891|PMID:17563371)
ARUK-UCL
BHF-UCL
PMID:17563371, PMID:26242911 MGI:MGI:5430891 NCBI chr15:69,076,025...69,190,082
Ensembl chr15:88,276,851...88,388,594
JBrowse link
G IREB2 iron responsive element binding protein 2 ISO RGD PMID:10889193 RGD:12910555 NCBI chr15:57,367,314...57,430,322
Ensembl chr15:76,331,610...76,394,476
JBrowse link
G KNSTRN kinetochore localized astrin (SPAG5) binding protein ISO (PMID:26242911) ARUK-UCL PMID:26242911 NCBI chr15:19,316,854...19,328,425 JBrowse link
G LOC100989105 signal transducer and activator of transcription 5B ISO PMID:20639532 UniProt PMID:20639532 RGD:8553583 NCBI chr17:15,040,303...15,116,682
Ensembl chr17:15,306,418...15,336,463
JBrowse link
G MARS1 methionyl-tRNA synthetase 1 ISO (PMID:10791971) CAFA PMID:10791971 NCBI chr12:31,410,231...31,438,015
Ensembl chr12:31,668,708...31,693,839
JBrowse link
G MCM7 minichromosome maintenance complex component 7 ISO RGD PMID:19821535 RGD:2316313 NCBI chr 7:92,128,037...92,136,976
Ensembl chr 7:105,561,591...105,570,720
JBrowse link
G MED1 mediator complex subunit 1 ISO (PMID:16314496) UniProtKB PMID:16314496 NCBI chr17:17,836,350...17,883,610
Ensembl chr17:18,050,474...18,095,118
JBrowse link
G MUC5AC mucin 5AC, oligomeric mucus/gel-forming ISO RGD PMID:11769575 RGD:2324971 NCBI chr11:1,191,223...1,234,373 JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor ISO RGD PMID:7524476 RGD:10059620 NCBI chr 8:124,387,561...124,393,551
Ensembl chr 8:127,131,512...127,136,863
JBrowse link
G NCL nucleolin ISO (MGI:MGI:82360|PMID:8702723) MGI PMID:8702723 MGI:MGI:82360 NCBI chr2B:118,703,148...118,712,893
Ensembl chr2B:237,490,378...237,500,193
JBrowse link
G PAX2 paired box 2 ISO RGD PMID:11262416 RGD:2316756 NCBI chr10:97,344,978...97,429,086
Ensembl chr10:100,822,676...100,904,028
JBrowse link
G PDE8A phosphodiesterase 8A ISO (PMID:23509299)
(MGI:MGI:5484722|PMID:23509299)
UniProtKB PMID:23509299 MGI:MGI:5484722 NCBI chr15:63,649,336...63,805,613
Ensembl chr15:82,971,986...83,127,957
JBrowse link
G PDPK1 3-phosphoinositide dependent protein kinase 1 ISO (PMID:22454520) BHF-UCL PMID:22454520 NCBI chr16:1,394,447...1,463,735 JBrowse link
G PLCG1 phospholipase C gamma 1 ISO (PMID:22454520)
(PMID:17229814)
BHF-UCL
UniProtKB
PMID:17229814, PMID:22454520 NCBI chr20:37,477,077...37,515,854
Ensembl chr20:38,572,709...38,615,145
JBrowse link
G PPP1R9B protein phosphatase 1 regulatory subunit 9B ISO RGD PMID:10620493 RGD:10002737 NCBI chr17:44,224,007...44,240,906
Ensembl chr17:49,098,089...49,126,932
JBrowse link
G PTPN11 protein tyrosine phosphatase non-receptor type 11 ISO (PMID:28074573) UniProtKB PMID:28074573 NCBI chr12:110,016,364...110,107,462
Ensembl chr12:113,435,669...113,503,762
JBrowse link
G PTPN12 protein tyrosine phosphatase non-receptor type 12 ISO (PMID:27134172) UniProtKB PMID:27134172 NCBI chr 7:69,457,158...69,560,111
Ensembl chr 7:83,268,834...83,371,120
JBrowse link
G RASA1 RAS p21 protein activator 1 ISO RGD PMID:2005883 RGD:10002731 NCBI chr 5:27,980,907...28,104,368
Ensembl chr 5:28,115,159...28,240,321
JBrowse link
G SNAI2 snail family transcriptional repressor 2 ISO (PMID:18716062) BHF-UCL PMID:18716062 NCBI chr 8:45,341,857...45,345,544
Ensembl chr 8:42,723,971...42,730,904
JBrowse link
G SNX6 sorting nexin 6 ISO RGD PMID:18523162 RGD:13513208 NCBI chr14:15,319,526...15,388,326
Ensembl chr14:33,511,019...33,576,705
JBrowse link
G SOX9 SRY-box transcription factor 9 ISO (MGI:MGI:5285125|PMID:21512138) UniProtKB PMID:21512138 MGI:MGI:5285125 NCBI chr17:66,028,737...66,034,122 JBrowse link
G SYAP1 synapse associated protein 1 ISO (MGI:MGI:6114863|PMID:23300339)
(PMID:23300339)
UniProtKB PMID:23300339 MGI:MGI:6114863 NCBI chr  X:9,339,052...9,384,940
Ensembl chr  X:16,706,612...16,747,610
JBrowse link
G TDGF1 teratocarcinoma-derived growth factor 1 ISO (PMID:17720976) UniProtKB PMID:17720976 NCBI chr 3:46,473,282...46,478,454
Ensembl chr 3:47,577,949...47,583,126
JBrowse link
G VIL1 villin 1 ISO (PMID:17229814) UniProtKB PMID:17229814 NCBI chr2B:105,677,371...105,711,293
Ensembl chr2B:224,274,548...224,304,550
JBrowse link
G ZFP36 ZFP36 ring finger protein ISO (PMID:20166898) UniProtKB PMID:20166898 NCBI chr19:36,505,056...36,507,693
Ensembl chr19:45,052,801...45,055,390
JBrowse link
G ZFP36L1 ZFP36 ring finger protein like 1 ISO (PMID:20166898) UniProtKB PMID:20166898 NCBI chr14:49,372,058...49,379,116
Ensembl chr14:68,247,347...68,255,805
JBrowse link
G ZFP36L2 ZFP36 ring finger protein like 2 ISO (PMID:20166898) UniProtKB PMID:20166898 NCBI chr2A:43,311,744...43,315,928 JBrowse link
G ZPR1 ZPR1 zinc finger ISO (PMID:9852145) UniProtKB PMID:9852145 NCBI chr11:111,613,940...111,623,539
Ensembl chr11:115,547,973...115,557,883
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12524
    response to stimulus 6721
      response to endogenous stimulus 1738
        response to epidermal growth factor 67
          cellular response to epidermal growth factor stimulus 57
Path 2
Term Annotations click to browse term
  biological_process 12524
    response to stimulus 6721
      response to chemical 3911
        response to organic substance 3139
          response to growth factor 732
            response to epidermal growth factor 67
              cellular response to epidermal growth factor stimulus 57
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.