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Term:microprocessor complex
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Accession:GO:0070877 term browser browse the term
Definition:A protein complex that binds to heme and to pri-miRNAs, and is required for the formation of a pre-microRNA (pre-miRNA), the initial step of microRNA (miRNA) biogenesis. The complex is composed of the double-stranded-RNA-specific RNase Drosha (also called RNASEN) and the RNA-binding protein DGCR8 (heme-free or heme-bound forms). Within the complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs RNASEN/Drosha to cleave the 3' and 5' strands of a stem-loop to release hairpin-shaped pre-miRNAs.
Synonyms:xref: IntAct:EBI-9519039;   IntAct:EBI-9519056

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microprocessor complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dgcr8 DGCR8 microprocessor complex subunit JBrowse link 11 86,852,682 86,885,233 RGD:1624291
G Drosha drosha ribonuclease III JBrowse link 2 62,887,267 63,000,307 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19949
    intracellular 13934
      endonuclease complex 38
        endoribonuclease complex 32
          ribonuclease III complex 2
            microprocessor complex 2
Path 2
Term Annotations click to browse term
  cellular_component 19949
    cellular anatomical entity 19598
      organelle 12670
        membrane-bounded organelle 10978
          intracellular membrane-bounded organelle 10066
            nucleus 6843
              microprocessor complex 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.