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ONTOLOGY REPORT - ANNOTATIONS


Term:protein K48-linked ubiquitination
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Accession:GO:0070936 term browser browse the term
Definition:A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation.
Synonyms:exact_synonym: protein K48-linked polyubiquitination


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protein K48-linked ubiquitination term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amfr autocrine motility factor receptor ISO
IBA
(PMID:12847084), (PMID:24424410)
PMID:21873635
RGD PMID:12847084, PMID:24424410, PMID:21873635 RGD:13792537 NCBI chr19:11,473,538...11,509,500
Ensembl chr19:11,473,541...11,508,102
JBrowse link
G Arih2 ariadne RBR E3 ubiquitin protein ligase 2 ISO (PMID:16118314), (PMID:19340006) RGD PMID:16118314, PMID:19340006 NCBI chr 8:117,387,004...117,446,085
Ensembl chr 8:117,387,010...117,446,019
JBrowse link
G Bfar bifunctional apoptosis regulator ISO (PMID:21068390) RGD PMID:21068390 NCBI chr10:1,464,658...1,471,152
NCBI chr10:1,464,783...1,497,653
Ensembl chr10:1,464,765...1,497,653
JBrowse link
G Btrc beta-transducin repeat containing E3 ubiquitin protein ligase ISO (MGI:6149282|PMID:29593216) RGD PMID:29593216 MGI:6149282 NCBI chr 1:265,100,094...265,270,263
Ensembl chr 1:265,157,379...265,269,837
JBrowse link
G Cdc34 cell division cycle 34, ubiqiutin conjugating enzyme ISO (PMID:20061386) RGD PMID:20061386 NCBI chr 7:12,899,957...12,905,339
Ensembl chr 7:12,899,958...12,905,339
JBrowse link
G Cul1 cullin 1 ISO (MGI:6149282|PMID:29593216) RGD PMID:29593216 MGI:6149282 NCBI chr 4:77,211,814...77,283,369
Ensembl chr 4:77,211,692...77,280,250
JBrowse link
G Dtx3l deltex E3 ubiquitin ligase 3L ISO (PMID:26479788) RGD PMID:26479788 NCBI chr11:67,758,093...67,767,623
NCBI chr11:67,768,542...67,772,428
Ensembl chr11:67,757,928...67,767,622
JBrowse link
G Fbxo38 F-box protein 38 ISO
IBA
(PMID:30487606)
PMID:21873635
RGD PMID:30487606, PMID:21873635 RGD:13792537 NCBI chr18:57,827,391...57,874,515
Ensembl chr18:57,827,392...57,866,741
JBrowse link
G Hace1 HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1 ISO
ISS
(PMID:22036506)
GO_REF:0000024
RGD
UniProt
PMID:22036506 GO_REF:0000024 NCBI chr20:50,652,489...50,783,937
Ensembl chr20:50,652,745...50,783,937
JBrowse link
G Ifi27 interferon, alpha-inducible protein 27 ISO (PMID:27194766) RGD PMID:27194766 NCBI chr 6:127,327,959...127,334,430
Ensembl chr 6:127,327,959...127,334,428
JBrowse link
G Itch itchy E3 ubiquitin protein ligase IBA
ISO
PMID:21873635
(MGI:3774677|PMID:18246070)
(PMID:19881509), (PMID:30328013)
RGD PMID:18246070, PMID:19881509, PMID:30328013, PMID:21873635 MGI:3774677, RGD:13792537 NCBI chr 3:150,660,665...150,752,016
Ensembl chr 3:150,686,638...150,749,827
JBrowse link
G Klhl3 kelch-like family member 3 ISO
IBA
ISS
(PMID:23576762)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:23576762, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr17:6,924,423...7,029,374
Ensembl chr17:6,935,860...7,029,240
JBrowse link
G Marchf6 membrane associated ring-CH-type finger 6 ISO (PMID:15673284) RGD PMID:15673284 NCBI chr 2:84,533,546...84,608,743
Ensembl chr 2:84,536,669...84,608,712
JBrowse link
G Nedd4l NEDD4 like E3 ubiquitin protein ligase ISO (PMID:21463633) RGD PMID:21463633 NCBI chr18:60,392,376...60,719,720
Ensembl chr18:60,392,376...60,719,720
JBrowse link
G Nhlrc4 NHL repeat containing 4 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:15,305,723...15,306,534
Ensembl chr10:15,306,108...15,306,515
JBrowse link
G Peli1 pellino E3 ubiquitin protein ligase 1 ISO
IBA
(PMID:29883609)
(MGI:5291872|PMID:21874024)
PMID:21873635
RGD PMID:21874024, PMID:29883609, PMID:21873635 MGI:5291872, RGD:13792537 NCBI chr14:106,008,086...106,062,566
Ensembl chr14:106,008,086...106,061,641
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISS
ISO
GO_REF:0000024
(PMID:21376232), (PMID:23858059)
UniProt
RGD
PMID:21376232, PMID:23858059 GO_REF:0000024 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Rbx1 ring-box 1 ISO (MGI:6149282|PMID:29593216) RGD PMID:29593216 MGI:6149282 NCBI chr 7:122,700,849...122,710,907
Ensembl chr 7:122,700,854...122,709,935
JBrowse link
G Rffl ring finger and FYVE-like domain containing E3 ubiquitin protein ligase ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(PMID:18450452), (PMID:22609986)
UniProt
RGD
PMID:18450452, PMID:22609986, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr10:70,157,621...70,220,618
Ensembl chr10:70,157,621...70,220,582
JBrowse link
G Rnf115 ring finger protein 115 ISO (MGI:5582879|PMID:23418353) RGD PMID:23418353 MGI:5582879 NCBI chr 2:198,852,392...198,920,000
Ensembl chr 2:198,852,500...198,919,995
JBrowse link
G Rnf126 ring finger protein 126 ISO (MGI:5582879|PMID:23418353) RGD PMID:23418353 MGI:5582879 NCBI chr 7:12,820,796...12,828,325
Ensembl chr 7:12,820,840...12,828,334
JBrowse link
G Rnf146 ring finger protein 146 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:21478859)
Ensembl
UniProt
RGD
PMID:21478859 GO_REF:0000024, GO_REF:0000107 NCBI chr 1:30,856,923...30,873,814
Ensembl chr 1:30,863,217...30,873,808
JBrowse link
G Rnf152 ring finger protein 152 ISO
IBA
ISS
(PMID:21203937)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:21203937, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr13:25,183,295...25,262,785
Ensembl chr13:25,186,106...25,262,469
JBrowse link
G Rnf187 ring finger protein 187 ISO
ISS
(PMID:20852630)
GO_REF:0000024
RGD
UniProt
PMID:20852630 GO_REF:0000024 NCBI chr10:45,273,400...45,279,299
Ensembl chr10:45,273,400...45,279,299
JBrowse link
G Rnf216 ring finger protein 216 ISO (PMID:19893624) RGD PMID:19893624 NCBI chr12:13,508,429...13,631,689
Ensembl chr12:13,508,429...13,632,304
JBrowse link
G Rnf34 ring finger protein 34 ISO
IBA
ISS
(PMID:25012219)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:25012219, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr12:39,164,290...39,185,209
Ensembl chr12:39,164,290...39,185,168
JBrowse link
G Rnf4 ring finger protein 4 IDA PMID:18408734 UniProt PMID:18408734 RGD:8553731 NCBI chr14:81,658,400...81,679,756
Ensembl chr14:81,660,354...81,679,082
JBrowse link
G Rnf5 ring finger protein 5 ISO (PMID:19285439) RGD PMID:19285439 NCBI chr20:4,366,244...4,368,690
Ensembl chr20:4,366,246...4,368,693
JBrowse link
G Rnf6 ring finger protein 6 ISO (MGI:3603857|PMID:16204183) RGD PMID:16204183 MGI:3603857 NCBI chr12:10,574,168...10,583,196
Ensembl chr12:10,574,168...10,583,208
JBrowse link
G Rnf8 ring finger protein 8 ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(PMID:21911360), (PMID:22266820), (PMID:22373579)
UniProt
RGD
PMID:21911360, PMID:22266820, PMID:22373579, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr20:8,285,380...8,309,858
Ensembl chr20:8,285,296...8,309,908
JBrowse link
G Skp1 S-phase kinase-associated protein 1 IEA
ISO
GO_REF:0000107
(MGI:6149282|PMID:29593216)
Ensembl
RGD
PMID:29593216 GO_REF:0000107, MGI:6149282 NCBI chr10:37,594,578...37,609,498
Ensembl chr10:37,594,578...37,609,498
JBrowse link
G Skp2 S-phase kinase associated protein 2 ISO (PMID:27194766) RGD PMID:27194766 NCBI chr 2:58,506,146...58,534,211
Ensembl chr 2:58,506,151...58,534,211
JBrowse link
G Syvn1 synoviolin 1 ISO (PMID:14593114) RGD PMID:14593114 NCBI chr 1:221,409,281...221,416,229
Ensembl chr 1:221,409,271...221,417,886
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 ISO (PMID:15258597) RGD PMID:15258597 NCBI chr 1:14,401,103...14,416,369
Ensembl chr 1:14,402,913...14,412,807
JBrowse link
G Topors TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase ISO (PMID:15247280) RGD PMID:15247280 NCBI chr 5:56,554,956...56,566,503
Ensembl chr 5:56,554,969...56,567,320
JBrowse link
G Trim32 tripartite motif-containing 32 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:81,431,554...81,449,023
Ensembl chr 5:81,431,600...81,442,451
JBrowse link
G Trim38 tripartite motif containing 38 ISO (MGI:5441682|PMID:22539786) RGD PMID:22539786 MGI:5441682 NCBI chr17:43,600,006...43,607,879 JBrowse link
G Ttc3 tetratricopeptide repeat domain 3 ISO (PMID:20059950) RGD PMID:20059950 NCBI chr11:34,598,324...34,739,986
Ensembl chr11:34,598,492...34,738,791
JBrowse link
G Ube2a ubiquitin-conjugating enzyme E2A ISO (PMID:20061386) RGD PMID:20061386 NCBI chr  X:123,486,988...123,497,726
Ensembl chr  X:123,486,989...123,497,726
JBrowse link
G Ube2b ubiquitin-conjugating enzyme E2B ISO
ISS
(PMID:20061386)
GO_REF:0000024
RGD
UniProt
PMID:20061386 GO_REF:0000024 NCBI chr10:37,439,947...37,454,867
Ensembl chr10:37,441,284...37,455,022
JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C ISO (PMID:20061386) RGD PMID:20061386 NCBI chr 3:161,236,971...161,239,371
Ensembl chr 3:161,236,898...161,241,159
JBrowse link
G Ube2d1 ubiquitin-conjugating enzyme E2D 1 ISO
IBA
ISS
(PMID:20061386)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:20061386, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr20:18,547,370...18,580,291
Ensembl chr20:18,547,370...18,580,291
JBrowse link
G Ube2d2 ubiquitin-conjugating enzyme E2D 2 ISO
IBA
IEA
ISS
(PMID:20061386)
PMID:21873635
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:20061386, PMID:21873635 GO_REF:0000024, GO_REF:0000107, RGD:13792537 NCBI chr18:28,561,957...28,603,335
Ensembl chr18:28,594,892...28,603,335
JBrowse link
G Ube2d3 ubiquitin-conjugating enzyme E2D 3 ISO
IBA
ISS
(PMID:20061386)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:20061386, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 2:240,626,198...240,655,874
Ensembl chr 2:240,627,436...240,655,246
JBrowse link
G Ube2d4 ubiquitin-conjugating enzyme E2D 4 (putative) ISO
IBA
(PMID:20061386)
PMID:21873635
RGD PMID:20061386, PMID:21873635 RGD:13792537 NCBI chr14:2,933,097...2,934,571
Ensembl chr14:2,933,100...2,934,571
JBrowse link
G Ube2e1 ubiquitin-conjugating enzyme E2E 1 ISO
IBA
(PMID:20061386)
PMID:21873635
RGD PMID:20061386, PMID:21873635 RGD:13792537 NCBI chr15:8,124,869...8,178,252
Ensembl chr15:8,125,526...8,177,781
JBrowse link
G Ube2e2 ubiquitin-conjugating enzyme E2E 2 ISO
IBA
(PMID:20061386)
PMID:21873635
RGD PMID:20061386, PMID:21873635 RGD:13792537 NCBI chr15:7,402,210...7,928,320
Ensembl chr15:7,871,497...7,927,939
JBrowse link
G Ube2e3 ubiquitin-conjugating enzyme E2E 3 ISO
IBA
(PMID:20061386)
PMID:21873635
RGD PMID:20061386, PMID:21873635 RGD:13792537 NCBI chr 3:65,815,076...65,876,256
Ensembl chr 3:65,815,080...65,871,363
JBrowse link
G Ube2g1 ubiquitin-conjugating enzyme E2G 1 ISS
ISO
GO_REF:0000024
(MGI:5634892|PMID:12847084)
(PMID:14593114), (PMID:20061386)
UniProt
RGD
PMID:12847084, PMID:14593114, PMID:20061386 GO_REF:0000024, MGI:5634892 NCBI chr10:59,173,268...59,254,458
Ensembl chr10:59,173,268...59,254,453
JBrowse link
G Ube2g2 ubiquitin-conjugating enzyme E2G 2 ISO (PMID:20061386) RGD PMID:20061386 NCBI chr20:11,700,089...11,721,823
Ensembl chr20:11,700,089...11,721,838
JBrowse link
G Ube2h ubiquitin-conjugating enzyme E2H ISO (PMID:20061386) RGD PMID:20061386 NCBI chr 4:57,511,418...57,625,147
Ensembl chr 4:57,511,418...57,625,257
JBrowse link
G Ube2k ubiquitin-conjugating enzyme E2K ISO (PMID:20061386) RGD PMID:20061386 NCBI chr14:44,289,247...44,348,691
Ensembl chr14:44,289,247...44,348,691
JBrowse link
G Ube2q2 ubiquitin conjugating enzyme E2 Q2 ISO
IBA
(PMID:20061386)
PMID:21873635
RGD PMID:20061386, PMID:21873635 RGD:13792537 NCBI chr 8:59,709,972...59,754,102
Ensembl chr 8:59,711,549...59,766,889
JBrowse link
G Ube2q2l ubiquitin-conjugating enzyme E2Q family member 2-like IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:10,771,112...10,772,633
Ensembl chr  X:10,771,112...10,772,633
JBrowse link
G Ube2r2 ubiquitin-conjugating enzyme E2R 2 ISO (PMID:20061386) RGD PMID:20061386 NCBI chr 5:57,472,315...57,530,973
Ensembl chr 5:57,472,315...57,530,987
JBrowse link
G Ube2t ubiquitin-conjugating enzyme E2T ISO (PMID:20061386) RGD PMID:20061386 NCBI chr13:51,790,877...51,801,379
Ensembl chr13:51,795,867...51,801,163
JBrowse link
G Ube3a ubiquitin protein ligase E3A ISO (PMID:12890688) RGD PMID:12890688 NCBI chr 1:116,586,901...116,678,161
Ensembl chr 1:116,587,815...116,679,973
JBrowse link
G Ubr5 ubiquitin protein ligase E3 component n-recognin 5 IEA
ISO
GO_REF:0000107
(PMID:28689657)
Ensembl
RGD
PMID:28689657 GO_REF:0000107 NCBI chr 7:76,789,110...76,835,517
NCBI chr 7:76,839,661...76,907,441
Ensembl chr 7:76,789,531...76,853,840
JBrowse link
G Znrf1 zinc and ring finger 1 ISO (MGI:5306704|PMID:22057101) RGD PMID:22057101 MGI:5306704 NCBI chr19:43,750,205...43,834,962
Ensembl chr19:43,750,278...43,832,878
JBrowse link
negative regulation of protein K48-linked ubiquitination term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppia peptidylprolyl isomerase A ISO
ISS
(PMID:30328013)
GO_REF:0000024
RGD
UniProt
PMID:30328013 GO_REF:0000024 NCBI chr14:86,673,775...86,677,443
Ensembl chr14:86,673,775...86,677,443
JBrowse link
G Ppial4d peptidylprolyl isomerase A (cyclophilin A)-like 4D ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr14:22,706,906...22,707,648
Ensembl chr14:22,706,901...22,707,668
JBrowse link
G Trim44 tripartite motif-containing 44 ISO
IEA
(PMID:23460740)
GO_REF:0000107
RGD
Ensembl
PMID:23460740 GO_REF:0000107 NCBI chr 3:91,968,781...92,242,138
Ensembl chr 3:92,183,556...92,242,318
JBrowse link
positive regulation of protein K48-linked ubiquitination term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc2 baculoviral IAP repeat-containing 2 ISO (PMID:21931591) RGD PMID:21931591 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142
JBrowse link
G Nmi N-myc (and STAT) interactor ISO (MGI:5546557|PMID:23956435) RGD PMID:23956435 MGI:5546557 NCBI chr 3:37,458,891...37,480,984
Ensembl chr 3:37,458,890...37,480,984
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    metabolic process 12263
      cellular metabolic process 11073
        cellular macromolecule metabolic process 8548
          cellular protein metabolic process 5564
            cellular protein modification process 3948
              protein modification by small protein conjugation or removal 951
                protein modification by small protein conjugation 815
                  protein ubiquitination 766
                    protein polyubiquitination 241
                      protein K48-linked ubiquitination 64
                        negative regulation of protein K48-linked ubiquitination 3
                        positive regulation of protein K48-linked ubiquitination 2
                        regulation of protein K48-linked ubiquitination + 5
Path 2
Term Annotations click to browse term
  biological_process 20020
    metabolic process 12263
      organic substance metabolic process 11643
        macromolecule metabolic process 10077
          protein metabolic process 6221
            protein modification process 3948
              cellular protein modification process 3948
                protein modification by small protein conjugation or removal 951
                  protein modification by small protein conjugation 815
                    protein ubiquitination 766
                      protein polyubiquitination 241
                        protein K48-linked ubiquitination 64
                          negative regulation of protein K48-linked ubiquitination 3
                          positive regulation of protein K48-linked ubiquitination 2
                          regulation of protein K48-linked ubiquitination + 5
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.