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ONTOLOGY REPORT - ANNOTATIONS


Term:catalytic step 1 spliceosome
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Accession:GO:0071012 term browser browse the term
Definition:A spliceosomal complex that is formed by the displacement of the two snRNPs from the precatalytic spliceosome; three snRNPs including U5 remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the associated snRNPs.
Synonyms:exact_synonym: activated spliceosome
 narrow_synonym: mammalian spliceosomal complex B*;   mammalian spliceosomal complex B2;   yeast spliceosomal complex A1


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U2-type catalytic step 1 spliceosome term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07024964.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr16:22,851,465...22,853,022 JBrowse link
G Casc3 CASC3 exon junction complex subunit ISS
ISO
IEA
GO_REF:0000024
(PMID:29301961)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:29301961 GO_REF:0000024, GO_REF:0000107 NCBI chr10:86,724,534...86,744,485
Ensembl chr10:86,724,427...86,745,927
JBrowse link
G Cwc22 CWC22 spliceosome associated protein homolog ISO (PMID:29301961) RGD PMID:29301961 NCBI chr 3:64,731,145...64,780,127
Ensembl chr 3:64,731,381...64,766,472
JBrowse link
G Cwc25 CWC25 spliceosome-associated protein homolog ISO (PMID:29301961) RGD PMID:29301961 NCBI chr10:85,684,898...85,709,568
Ensembl chr10:85,684,898...85,709,568
JBrowse link
G Eif4a3 eukaryotic translation initiation factor 4A3 ISS
ISO
GO_REF:0000024
(PMID:29301961)
UniProt
RGD
PMID:29301961 GO_REF:0000024 NCBI chr10:108,415,201...108,425,195
Ensembl chr10:108,415,202...108,425,206
JBrowse link
G Isy1 ISY1 splicing factor homolog ISS
ISO
GO_REF:0000024
(PMID:29301961)
UniProt
RGD
PMID:29301961 GO_REF:0000024 NCBI chr 4:119,721,659...119,742,349
Ensembl chr 4:119,721,660...119,742,349
JBrowse link
G Magohb mago homolog B, exon junction complex subunit ISO (PMID:29301961) RGD PMID:29301961 NCBI chr 4:165,514,584...165,522,366
Ensembl chr 4:165,514,530...165,522,418
JBrowse link
G Prpf19 pre-mRNA processing factor 19 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:226,947,065...226,958,147
Ensembl chr 1:226,947,105...226,958,144
JBrowse link
G Prpf8 pre-mRNA processing factor 8 ISO (PMID:29301961) RGD PMID:29301961 NCBI chr10:63,635,239...63,658,360
Ensembl chr10:63,635,219...63,658,361
JBrowse link
G Rbm22 RNA binding motif protein 22 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr18:55,828,158...55,839,421
Ensembl chr18:55,828,158...55,838,966
JBrowse link
G Rbm8a RNA binding motif protein 8A ISS
ISO
GO_REF:0000024
(PMID:29301961)
UniProt
RGD
PMID:29301961 GO_REF:0000024 NCBI chr 2:198,755,261...198,758,028
Ensembl chr 2:198,755,262...198,758,028
JBrowse link
G Snrnp200 small nuclear ribonucleoprotein U5 subunit 200 ISS
ISO
IEA
GO_REF:0000024
(PMID:29301961)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:29301961 GO_REF:0000024, GO_REF:0000107 NCBI chr 3:119,640,324...119,669,651
Ensembl chr 3:119,640,298...119,669,639
JBrowse link
G Yju2 YJU2 splicing factor homolog ISO
IBA
(PMID:29301961)
PMID:21873635
RGD PMID:29301961, PMID:21873635 RGD:13792537 NCBI chr 9:11,098,914...11,108,806
Ensembl chr 9:11,098,924...11,108,741
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20602
    protein-containing complex 6103
      catalytic complex 1496
        catalytic step 1 spliceosome 13
          U12-type catalytic step 1 spliceosome 0
          U2-type catalytic step 1 spliceosome 13
Path 2
Term Annotations click to browse term
  cellular_component 20602
    cellular anatomical entity 20292
      organelle 13274
        membrane-bounded organelle 11259
          intracellular membrane-bounded organelle 10515
            nucleus 6984
              nuclear protein-containing complex 1251
                spliceosomal complex 200
                  catalytic step 1 spliceosome 13
                    U12-type catalytic step 1 spliceosome 0
                    U2-type catalytic step 1 spliceosome 13
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.