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ONTOLOGY REPORT - ANNOTATIONS


Term:catalytic step 2 spliceosome
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Accession:GO:0071013 term browser browse the term
Definition:A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.
Synonyms:narrow_synonym: mammalian spliceosomal complex C;   mammalian spliceosomal complex C1;   yeast spliceosomal complex A2-2


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catalytic step 2 spliceosome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07042226.1 RGD:13792537
G AC126899.1 RGD:13792537
G Alyref Aly/REF export factor JBrowse link 10 109,768,593 109,774,639 RGD:1624291
G Aqr aquarius intron-binding spliceosomal factor JBrowse link 3 105,570,399 105,640,431 RGD:1624291
RGD:13792537
G Bcas2 BCAS2, pre-mRNA processing factor JBrowse link 2 205,662,633 205,670,514 RGD:13792537
G Cactin cactin, spliceosome C complex subunit JBrowse link 7 11,258,526 11,266,509 RGD:1624291
G Cdc40 cell division cycle 40 JBrowse link 20 48,503,973 48,574,546 RGD:1624291
RGD:13792537
G Cdc5l cell division cycle 5-like JBrowse link 9 17,949,764 17,988,514 RGD:1624291
G Crnkl1 crooked neck pre-mRNA splicing factor 1 JBrowse link 6 18,349,226 18,351,540 RGD:1624291
RGD:13792537
G Cwc15 CWC15 spliceosome-associated protein JBrowse link 8 12,994,131 13,004,958 RGD:1624291
RGD:13792537
G Cwc22 CWC22 spliceosome associated protein homolog JBrowse link 3 64,731,145 64,780,127 RGD:1624291
RGD:13792537
G Cwc27 CWC27 spliceosome associated cyclophilin JBrowse link 2 34,716,420 34,923,060 RGD:1624291
G Ddx23 DEAD-box helicase 23 JBrowse link 7 140,325,453 140,342,730 RGD:1624291
RGD:13792537
G Ddx41 DEAD-box helicase 41 JBrowse link 17 9,631,925 9,637,317 RGD:1624291
G Ddx5 DEAD-box helicase 5 JBrowse link 10 94,979,759 94,988,461 RGD:1624291
G Dhx35 DEAH-box helicase 35 JBrowse link 3 155,297,545 155,354,857 RGD:1624291
RGD:13792537
G Dhx38 DEAH-box helicase 38 JBrowse link 19 42,110,291 42,127,540 RGD:1624291
G Dhx8 DEAH-box helicase 8 JBrowse link 10 89,645,979 89,683,839 RGD:1624291
RGD:13792537
G Eftud2 elongation factor Tu GTP binding domain containing 2 JBrowse link 10 90,932,071 90,983,971 RGD:1624291
G Eif4a3 eukaryotic translation initiation factor 4A3 JBrowse link 10 108,415,201 108,425,195 RGD:1624291
RGD:13792537
G Ess2 ess-2 splicing factor homolog JBrowse link 11 87,224,371 87,234,329 RGD:1624291
G Frg1 FSHD region gene 1 JBrowse link 16 53,957,858 53,978,865 RGD:1624291
RGD:13792537
G Gpatch1 G patch domain containing 1 JBrowse link 1 91,529,096 91,578,032 RGD:1624291
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 JBrowse link 7 144,865,302 144,871,592 RGD:1624291
RGD:1600115
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 JBrowse link 4 81,237,496 81,241,281 RGD:1600115
RGD:1624291
G Hnrnpa3 heterogeneous nuclear ribonucleoprotein A3 JBrowse link 3 62,481,222 62,491,356 RGD:1624291
G Hnrnpc heterogeneous nuclear ribonucleoprotein C JBrowse link 15 28,486,605 28,517,353 RGD:1624291
G Hnrnpf heterogeneous nuclear ribonucleoprotein F JBrowse link 4 149,957,143 149,978,896 RGD:1624291
G Hnrnph1 heterogeneous nuclear ribonucleoprotein H1 JBrowse link 10 35,872,619 35,879,911 RGD:1600115
RGD:1624291
G Hnrnpk heterogeneous nuclear ribonucleoprotein K JBrowse link 17 6,664,730 6,676,753 RGD:1624291
G Hnrnpm heterogeneous nuclear ribonucleoprotein M JBrowse link 7 18,516,253 18,554,536 RGD:1624291
RGD:1600115
G Hnrnpr heterogeneous nuclear ribonucleoprotein R JBrowse link 5 154,668,194 154,699,967 RGD:1624291
G Hnrnpu heterogeneous nuclear ribonucleoprotein U JBrowse link 13 96,222,093 96,238,845 RGD:1600115
RGD:13792537
RGD:1624291
G Isy1 ISY1 splicing factor homolog JBrowse link 4 119,721,659 119,742,349 RGD:1624291
RGD:13792537
G LOC102548514 crooked neck-like protein 1-like JBrowse link 3 140,125,232 140,141,730 RGD:13792537
G LOC500684 hypothetical protein LOC500684 JBrowse link 6 103,932,428 103,935,122 RGD:13792537
G LOC687679 similar to small nuclear ribonucleoprotein polypeptide G JBrowse link 1 91,588,215 91,588,629 RGD:13792537
G Lsm2 LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated JBrowse link 20 4,966,817 4,970,567 RGD:1624291
RGD:13792537
G Lsm3 LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated JBrowse link 4 123,162,086 123,168,330 RGD:1624291
RGD:13792537
G Lsm7 LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated JBrowse link 7 11,724,932 11,732,020 RGD:13792537
G Magoh mago homolog, exon junction complex subunit JBrowse link 5 127,480,465 127,487,617 RGD:1624291
RGD:13792537
G Magohb mago homolog B, exon junction complex subunit JBrowse link 4 165,514,584 165,522,366 RGD:13792537
G Mtrex Mtr4 exosome RNA helicase JBrowse link 2 44,726,716 44,787,013 RGD:1624291
G Pabpc1 poly(A) binding protein, cytoplasmic 1 JBrowse link 7 75,409,581 75,421,874 RGD:1624291
G Plrg1 pleiotropic regulator 1 JBrowse link 2 182,040,338 182,056,669 RGD:1624291
RGD:13792537
G Pnn pinin, desmosome associated protein JBrowse link 6 80,159,364 80,167,677 RGD:1624291
RGD:13792537
G Ppie peptidylprolyl isomerase E JBrowse link 5 140,822,141 140,835,244 RGD:1624291
G Ppil1 peptidylprolyl isomerase like 1 JBrowse link 20 6,515,638 6,864,571 RGD:1624291
G Ppil3 peptidylprolyl isomerase like 3 JBrowse link 9 65,315,407 65,329,145 RGD:1624291
G Ppwd1 peptidylprolyl isomerase domain and WD repeat containing 1 JBrowse link 2 34,288,853 34,313,094 RGD:1624291
G Prpf19 pre-mRNA processing factor 19 JBrowse link 1 226,947,065 226,958,147 RGD:1624291
RGD:13792537
G Prpf4b pre-mRNA processing factor 4B JBrowse link 17 30,680,454 30,714,542 RGD:1624291
G Prpf6 pre-mRNA processing factor 6 JBrowse link 3 177,098,137 177,162,937 RGD:1624291
RGD:13792537
G Prpf8 pre-mRNA processing factor 8 JBrowse link 10 63,635,239 63,658,360 RGD:1624291
RGD:13792537
G Raly RALY heterogeneous nuclear ribonucleoprotein JBrowse link 3 150,322,834 150,387,345 RGD:1624291
G Rbm22 RNA binding motif protein 22 JBrowse link 18 55,828,158 55,839,421 RGD:1624291
G Rbm8a RNA binding motif protein 8A JBrowse link 2 198,755,261 198,758,028 RGD:1624291
G Rbmx RNA binding motif protein, X-linked JBrowse link X 159,881,835 159,891,405 RGD:1624291
G Rbmxl1 RBMX like 1 JBrowse link 19 33,081,473 33,084,988 RGD:1600115
G Sart1 spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP JBrowse link 1 220,762,496 220,771,158 RGD:1624291
G Sf3a1 splicing factor 3a, subunit 1 JBrowse link 14 84,393,182 84,413,931 RGD:1624291
RGD:13792537
G Sf3a2 splicing factor 3a, subunit 2 JBrowse link 7 11,777,826 11,784,373 RGD:1624291
RGD:13792537
G Sf3a3 splicing factor 3a, subunit 3 JBrowse link 5 142,702,721 142,722,350 RGD:1624291
G Sf3b1 splicing factor 3b, subunit 1 JBrowse link 9 61,594,620 61,634,510 RGD:1624291
RGD:13792537
G Sf3b2 splicing factor 3b, subunit 2 JBrowse link 1 220,645,685 220,665,611 RGD:1624291
RGD:13792537
G Sf3b3 splicing factor 3b, subunit 3 JBrowse link 19 43,392,071 43,429,582 RGD:1624291
G Slu7 SLU7 homolog, splicing factor JBrowse link 10 29,029,556 29,044,919 RGD:1624291
G Snrnp200 small nuclear ribonucleoprotein U5 subunit 200 JBrowse link 3 119,640,324 119,669,651 RGD:1600115
RGD:1624291
G Snrnp40 small nuclear ribonucleoprotein U5 subunit 40 JBrowse link 5 148,577,498 148,610,658 RGD:1624291
G Snrpa1 small nuclear ribonucleoprotein polypeptide A' JBrowse link 1 126,961,389 126,974,453 RGD:1624291
G Snrpb small nuclear ribonucleoprotein polypeptides B and B1 JBrowse link 3 122,696,125 122,703,734 RGD:1624291
RGD:13792537
G Snrpb2 small nuclear ribonucleoprotein polypeptide B2 JBrowse link 3 137,138,082 137,147,575 RGD:1624291
RGD:13792537
G Snrpd1 small nuclear ribonucleoprotein D1 polypeptide JBrowse link 18 1,866,066 1,876,613 RGD:1624291
RGD:13792537
G Snrpd2 small nuclear ribonucleoprotein D2 polypeptide JBrowse link 1 80,057,140 80,059,990 RGD:1624291
RGD:13792537
G Snrpd2l small nuclear ribonucleoprotein D2-like JBrowse link 20 28,872,902 28,873,434 RGD:13792537
G Snrpd3 small nuclear ribonucleoprotein D3 polypeptide JBrowse link 20 14,080,562 14,095,644 RGD:1624291
RGD:13792537
G Snrpe small nuclear ribonucleoprotein polypeptide E JBrowse link 13 50,252,707 50,258,951 RGD:1624291
G Snrpf small nuclear ribonucleoprotein polypeptide F JBrowse link 7 34,478,331 34,485,034 RGD:1624291
RGD:13792537
G Snrpg small nuclear ribonucleoprotein polypeptide G JBrowse link 4 118,167,267 118,174,846 RGD:1624291
RGD:13792537
G Snrpn small nuclear ribonucleoprotein polypeptide N JBrowse link 1 195,074,328 195,096,460 RGD:13792537
G Snw1 SNW domain containing 1 JBrowse link 6 111,483,698 111,507,782 RGD:1624291
G Srrm1 serine and arginine repetitive matrix 1 JBrowse link 5 153,675,619 153,708,187 RGD:1624291
G Srrm2 serine/arginine repetitive matrix 2 JBrowse link 10 13,128,820 13,162,956 RGD:1624291
G Srsf1 serine and arginine rich splicing factor 1 JBrowse link 10 75,334,200 75,341,197 RGD:1624291
G Syf2 SYF2 pre-mRNA-splicing factor JBrowse link 5 153,269,638 153,277,562 RGD:1624291
RGD:13792537
G Syncrip synaptotagmin binding, cytoplasmic RNA interacting protein JBrowse link 8 96,100,692 96,266,342 RGD:1600115
RGD:1624291
G Tfip11 tuftelin interacting protein 11 JBrowse link 12 50,320,820 50,333,052 RGD:1624291
G U2af1 U2 small nuclear RNA auxiliary factor 1 JBrowse link 20 10,396,652 10,407,564 RGD:1624291
G Wdr83 WD repeat domain 83 JBrowse link 19 26,188,644 26,194,193 RGD:1600115
RGD:1624291
G Xab2 XPA binding protein 2 JBrowse link 12 2,158,391 2,170,397 RGD:1624291
RGD:13792537
G Zcchc8 zinc finger CCHC-type containing 8 JBrowse link 12 38,303,665 38,327,174 RGD:1624291
U2-type catalytic step 2 spliceosome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aqr aquarius intron-binding spliceosomal factor JBrowse link 3 105,570,399 105,640,431 RGD:1624291
G Bcas2 BCAS2, pre-mRNA processing factor JBrowse link 2 205,662,633 205,670,514 RGD:1624291
G Bud31 BUD31 homolog JBrowse link 12 11,232,963 11,240,449 RGD:1624291
G Cdc40 cell division cycle 40 JBrowse link 20 48,503,973 48,574,546 RGD:1624291
G Cdc5l cell division cycle 5-like JBrowse link 9 17,949,764 17,988,514 RGD:1624291
RGD:1600115
G Crnkl1 crooked neck pre-mRNA splicing factor 1 JBrowse link 6 18,349,226 18,351,540 RGD:1600115
RGD:13792537
RGD:1624291
G Cwc15 CWC15 spliceosome-associated protein JBrowse link 8 12,994,131 13,004,958 RGD:1624291
RGD:1600115
G Cwc22 CWC22 spliceosome associated protein homolog JBrowse link 3 64,731,145 64,780,127 RGD:1624291
G Dhx8 DEAH-box helicase 8 JBrowse link 10 89,645,979 89,683,839 RGD:1624291
G Eftud2 elongation factor Tu GTP binding domain containing 2 JBrowse link 10 90,932,071 90,983,971 RGD:1624291
RGD:13792537
G LOC102548514 crooked neck-like protein 1-like JBrowse link 3 140,125,232 140,141,730 RGD:1600115
RGD:13792537
G Plrg1 pleiotropic regulator 1 JBrowse link 2 182,040,338 182,056,669 RGD:1624291
RGD:1600115
G Ppie peptidylprolyl isomerase E JBrowse link 5 140,822,141 140,835,244 RGD:1624291
G Ppil1 peptidylprolyl isomerase like 1 JBrowse link 20 6,515,638 6,864,571 RGD:1624291
G Prpf19 pre-mRNA processing factor 19 JBrowse link 1 226,947,065 226,958,147 RGD:1624291
G Prpf8 pre-mRNA processing factor 8 JBrowse link 10 63,635,239 63,658,360 RGD:1624291
G Rbm22 RNA binding motif protein 22 JBrowse link 18 55,828,158 55,839,421 RGD:1624291
RGD:13792537
G Snrnp40 small nuclear ribonucleoprotein U5 subunit 40 JBrowse link 5 148,577,498 148,610,658 RGD:1624291
G Snrpa1 small nuclear ribonucleoprotein polypeptide A' JBrowse link 1 126,961,389 126,974,453 RGD:1624291
G Snrpb small nuclear ribonucleoprotein polypeptides B and B1 JBrowse link 3 122,696,125 122,703,734 RGD:1624291
RGD:1600115
G Snrpb2 small nuclear ribonucleoprotein polypeptide B2 JBrowse link 3 137,138,082 137,147,575 RGD:1624291
G Snrpd1 small nuclear ribonucleoprotein D1 polypeptide JBrowse link 18 1,866,066 1,876,613 RGD:1624291
G Snrpd2 small nuclear ribonucleoprotein D2 polypeptide JBrowse link 1 80,057,140 80,059,990 RGD:1624291
G Snrpd3 small nuclear ribonucleoprotein D3 polypeptide JBrowse link 20 14,080,562 14,095,644 RGD:1624291
G Snrpe small nuclear ribonucleoprotein polypeptide E JBrowse link 13 50,252,707 50,258,951 RGD:1624291
G Snrpf small nuclear ribonucleoprotein polypeptide F JBrowse link 7 34,478,331 34,485,034 RGD:1624291
G Snrpg small nuclear ribonucleoprotein polypeptide G JBrowse link 4 118,167,267 118,174,846 RGD:1624291
G Snw1 SNW domain containing 1 JBrowse link 6 111,483,698 111,507,782 RGD:1624291
G Srrm2 serine/arginine repetitive matrix 2 JBrowse link 10 13,128,820 13,162,956 RGD:1624291
G Syf2 SYF2 pre-mRNA-splicing factor JBrowse link 5 153,269,638 153,277,562 RGD:1624291
RGD:1600115
G Xab2 XPA binding protein 2 JBrowse link 12 2,158,391 2,170,397 RGD:1600115
RGD:13792537
RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19843
    protein-containing complex 5779
      catalytic complex 1437
        catalytic step 2 spliceosome 92
          U12-type catalytic step 2 spliceosome 0
          U2-type catalytic step 2 spliceosome 31
Path 2
Term Annotations click to browse term
  cellular_component 19843
    cellular anatomical entity 19457
      organelle 12557
        membrane-bounded organelle 10879
          intracellular membrane-bounded organelle 9976
            nucleus 6783
              spliceosomal complex 191
                catalytic step 2 spliceosome 92
                  U12-type catalytic step 2 spliceosome 0
                  U2-type catalytic step 2 spliceosome 31
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.