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Term:NF-kappaB complex
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Accession:GO:0071159 term browser browse the term
Definition:A protein complex that consists of a homo- or heterodimer of members of a family of structurally related proteins that contain a conserved N-terminal region called the Rel homology domain (RHD). In the nucleus, NF-kappaB complexes act as transcription factors. In unstimulated cells, NF-kappaB dimers are sequestered in the cytoplasm by IkappaB monomers; signals that induce NF-kappaB activity cause degradation of IkappaB, allowing NF-kappaB dimers to translocate to the nucleus and induce gene expression.

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NF-kappaB complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rps3 ribosomal protein S3 JBrowse link 1 164,435,868 164,441,167 RGD:1624291
NF-kappaB p50/p65 complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:1624291

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  cellular_component 19949
    protein-containing complex 5829
      NF-kappaB complex 2
        NF-kappaB p50/p65 complex 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.