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ONTOLOGY REPORT - ANNOTATIONS


Term:spindle assembly checkpoint
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Accession:GO:0071173 term browser browse the term
Definition:A cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and chromosomes are attached to the spindle.
Comment:Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of spindle assembly checkpoint (mitotic or meiotic).
Synonyms:broad_synonym: SAC


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deactivation of mitotic spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdt1 chromatin licensing and DNA replication factor 1 ISO (PMID:22581055) CAFA PMID:22581055 NCBI chrNW_004936641:916,695...925,411 JBrowse link
meiotic spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ttk TTK protein kinase ISO (MGI:MGI:5049806|PMID:21558374) MGI PMID:21558374 MGI:MGI:5049806 NCBI chrNW_004936510:10,176,968...10,213,483 JBrowse link
mitotic spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC regulator of WNT signaling pathway ISO (PMID:17227893) MGI PMID:17227893 NCBI chrNW_004936531:6,899,580...7,019,016 JBrowse link
G Atm ATM serine/threonine kinase ISO (PMID:11943150) UniProtKB PMID:11943150 NCBI chrNW_004936551:359,134...534,672 JBrowse link
G Birc5 baculoviral IAP repeat containing 5 ISO (PMID:12805209) UniProtKB PMID:12805209 NCBI chrNW_004936594:2,812,165...2,820,618 JBrowse link
G Cenpe centromere protein E ISO (MGI:MGI:2673075|PMID:12925705) UniProtKB PMID:12925705 MGI:MGI:2673075 NCBI chrNW_004936520:188,601...265,904 JBrowse link
G Ik IK cytokine ISO (PMID:22351768) UniProtKB PMID:22351768 NCBI chrNW_004936531:9,589,035...9,601,266 JBrowse link
G Klhl22 kelch like family member 22 ISO (PMID:23455478) UniProtKB PMID:23455478 NCBI chrNW_004936619:2,854,915...2,899,386 JBrowse link
G Mad1l1 mitotic arrest deficient 1 like 1 ISO (PMID:18981471) UniProt PMID:18981471 NCBI chrNW_004936754:1,842,588...1,957,116 JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 ISO (PMID:18981471)
(MGI:MGI:1930685|PMID:11201745)
UniProt
MGI
PMID:11201745, PMID:18981471 MGI:MGI:1930685 NCBI chrNW_004936662:92,421...98,531 JBrowse link
G Plk1 polo like kinase 1 ISO (PMID:23455478) UniProtKB PMID:23455478 NCBI chrNW_004936501:8,321,415...8,332,414 JBrowse link
G Psmg2 proteasome assembly chaperone 2 ISO (MGI:MGI:2388532|PMID:12147697) MGI PMID:12147697 MGI:MGI:2388532 NCBI chrNW_004936626:2,328,646...2,344,831 JBrowse link
G Tex14 testis expressed 14, intercellular bridge forming factor ISO (MGI:MGI:5318128|PMID:22405274) UniProtKB PMID:22405274 MGI:MGI:5318128 NCBI chrNW_004936490:4,499,825...4,576,952 JBrowse link
G Tpr translocated promoter region, nuclear basket protein ISO (PMID:20133940) UniProt PMID:20133940 NCBI chrNW_004936481:4,050,693...4,111,682 JBrowse link
G Trip13 thyroid hormone receptor interactor 13 ISO (PMID:28553959) UniProtKB PMID:28553959 NCBI chrNW_004936815:734,029...745,381 JBrowse link
G Ttk TTK protein kinase ISO (MGI:MGI:5608719|PMID:25197064) MGI PMID:25197064 MGI:MGI:5608719 NCBI chrNW_004936510:10,176,968...10,213,483 JBrowse link
G Znf207 zinc finger protein 207 ISO (PMID:24462186), (PMID:24462187) UniProtKB PMID:24462186, PMID:24462187 NCBI chrNW_004936538:2,514,772...2,541,198 JBrowse link
positive regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dync1li1 dynein cytoplasmic 1 light intermediate chain 1 ISO (PMID:19229290) UniProtKB PMID:19229290 NCBI chrNW_004936473:23,011,888...23,042,497 JBrowse link
G Gen1 GEN1 Holliday junction 5' flap endonuclease ISO (PMID:23108668) UniProtKB PMID:23108668 NCBI chrNW_004936493:13,157,114...13,182,797 JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 ISO (MGI:MGI:4839685|PMID:20870947)
(PMID:20870947)
UniProtKB PMID:20870947 MGI:MGI:4839685 NCBI chrNW_004936662:92,421...98,531 JBrowse link
G Ndc80 NDC80 kinetochore complex component ISO (PMID:25743205) UniProtKB PMID:25743205 NCBI chrNW_004936672:1,872,205...1,910,956 JBrowse link
G Pcid2 PCI domain containing 2 ISO (PMID:20870947)
(MGI:MGI:4839685|PMID:20870947)
UniProtKB PMID:20870947 MGI:MGI:4839685 NCBI chrNW_004936472:440,440...464,116 JBrowse link
G Tpr translocated promoter region, nuclear basket protein ISO (PMID:18981471), (PMID:19273613) UniProt PMID:18981471, PMID:19273613 NCBI chrNW_004936481:4,050,693...4,111,682 JBrowse link
G Xrcc3 X-ray repair cross complementing 3 ISO (PMID:23108668) UniProtKB PMID:23108668 NCBI chrNW_004936621:1,462,441...1,474,937 JBrowse link
regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anapc15 anaphase promoting complex subunit 15 ISO (PMID:21926987) UniProtKB PMID:21926987 NCBI chrNW_004936498:1,460,795...1,468,363 JBrowse link
G Ccnb1 cyclin B1 ISO (PMID:18195732) BHF-UCL PMID:18195732 NCBI chrNW_004936480:400,287...407,677 JBrowse link
G Cdk5rap2 CDK5 regulatory subunit associated protein 2 ISO (PMID:19282672) UniProtKB PMID:19282672 NCBI chrNW_004936487:8,900,375...9,081,547 JBrowse link
G Lcmt1 leucine carboxyl methyltransferase 1 ISO (PMID:17724024) MGI PMID:17724024 NCBI chrNW_004936501:9,354,607...9,397,675 JBrowse link
G Usp44 ubiquitin specific peptidase 44 ISO (MGI:MGI:5448515|PMID:21853124) UniProtKB PMID:21853124 MGI:MGI:5448515 NCBI chrNW_004936507:11,663,069...11,692,174 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12001
    cellular process 11174
      cell cycle checkpoint 128
        spindle checkpoint 26
          spindle assembly checkpoint 26
            detection of stimulus involved in spindle assembly checkpoint + 0
            meiotic spindle assembly checkpoint + 1
            mitotic spindle assembly checkpoint + 26
            signal transduction involved in spindle assembly checkpoint + 0
Path 2
Term Annotations click to browse term
  biological_process 12001
    biological regulation 8793
      regulation of biological process 8336
        regulation of cellular process 7913
          negative regulation of cellular process 4248
            negative regulation of cell cycle 372
              cell cycle checkpoint 128
                spindle checkpoint 26
                  spindle assembly checkpoint 26
                    detection of stimulus involved in spindle assembly checkpoint + 0
                    meiotic spindle assembly checkpoint + 1
                    mitotic spindle assembly checkpoint + 26
                    signal transduction involved in spindle assembly checkpoint + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.