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ONTOLOGY REPORT - ANNOTATIONS


Term:death-inducing signaling complex assembly
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Accession:GO:0071550 term browser browse the term
Definition:A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a death domain (DD) interaction, as part of the extrinsic apoptotic signaling pathway.
Synonyms:exact_synonym: DD-mediated complex assembly;   DISC assembly;   DISC formation;   death domain-mediated complex assembly;   death domain-mediated complex assembly involved in extrinsic apoptotic pathway;   death-inducing signaling complex formation;   death-inducing signalling complex assembly


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death-inducing signaling complex assembly term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase ISO MGI:MGI:2388026 (MGI:MGI:3612236|PMID:16365167) RGD PMID:16365167 MGI:MGI:3612236 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
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negative regulation of death-inducing signaling complex assembly term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nol3 nucleolar protein 3 IDA PMID:12191471
PMID:15383280
UniProt PMID:12191471, PMID:15383280 RGD:631884, RGD:10047289 NCBI chr19:37,232,567...37,236,668
Ensembl chr19:37,235,001...37,236,649
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Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    signaling 7588
      signal transduction 7015
        apoptotic signaling pathway 635
          extrinsic apoptotic signaling pathway 236
            death-inducing signaling complex assembly 2
              TRAIL death-inducing signaling complex assembly 0
              negative regulation of death-inducing signaling complex assembly 1
              regulation of death-inducing signaling complex assembly + 1
Path 2
Term Annotations click to browse term
  biological_process 20014
    cellular process 18788
      cell death 2154
        programmed cell death 1968
          apoptotic process 1922
            apoptotic signaling pathway 635
              extrinsic apoptotic signaling pathway 236
                death-inducing signaling complex assembly 2
                  TRAIL death-inducing signaling complex assembly 0
                  negative regulation of death-inducing signaling complex assembly 1
                  regulation of death-inducing signaling complex assembly + 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.